Erlotinib Hydrochloride CAS 183319-69-9 Ịdị ọcha>99.0% (HPLC)

Nkọwa dị mkpirikpi:

Aha kemịkal: Erlotinib Hydrochloride

Ụdị okwu: Erlotinib HCl;Tarceva

OZI: 183319-69-9

Ịdị ọcha (HPLC):>99.0%

Ọdịdị: White ka Gbanyụọ-White Crystalline ntụ ntụ

Kpọtụrụ: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Zitere anyị email

Nkọwa ngwaahịa

Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Nkọwa:

Onye na-emepụta ihe na onye na-ebubata Erlotinib Hydrochloride Intermediates
Erlotinib Hydrochloride CAS 183319-69-9
3-Ethynylaniline CAS 54060-30-9
6,7-Bis (2-Methoxyethoxy) -3H-Quinazolin-4-otu CAS 179688-29-0
Please contact: alvin@ruifuchem.com

Njirimara kemịkalụ:

Aha Chemical	Erlotinib Hydrochloride
Ụdị okwu	Erlotinib HCl;Tarceva;CP-358774 Hydrochloride;6,7-Bis (2-methoxyethoxy) -4- (3-ethynylanilino) quinazoline Hydrochloride;N- (3-Ethynylphe nyl) [6,7-bis (2-methoxyethoxy) quinazolin-4-yl] amine HCl.
Nọmba CAS	183319-69-9
Nọmba CAT	RF-PI2242
Ọnọdụ Ahịa	N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi	C22H24ClN3O4
Ibu molekụla	429.90
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Ntụ ntụ kristal na-acha ọcha ruo na-agbanyụọ
njirimara	A: IR: Na-adaba na Spectrum Reference B: HPLC: Na-anabata nrụtụ aka RT
Solubility	Na-agbaze nke ukwuu n'ime mmiri, na-agbaze ntakịrị na methanol yana enweghị ike ime ya na Acetonitrile, Acetone, Ethyl Acetate na Hexane.
Ebe Na-agbaze	223.0 ~ 229.0 ℃
Ọnwụ na ihicha	<0.50%
Ihe fọdụrụ na mgbanye	<0.20%
Ọla dị arọ	<20ppm
Otu adịghị ọcha	<0.50%
Mgbakọta adịghị ọcha	<1.00%
Ihe mgbaze fọdụrụnụ
Pyridine	<4000ppm
Chloroform	<4000ppm
DMF	<3000ppm
Ụzọ ịdị ọcha / nyocha	> 99.0%
Usoro nyocha / nyocha	98.5% ~ 101.0% (Achịkọtara na Anhydrous ndabere)
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	API

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri

Uru:

Ajụjụ:

Ngwa:

Erlotinib Hydrochloride (CAS: 183319-69-9) bụ obere molekul nke epidermal growth factor receptor tyrosine kinase reversible inhibitor, na-ejikarị na ọgwụgwọ nke mpaghara ma ọ bụ metastatic na-abụghị obere cell akpa ume cancer na nke abụọ ma ọ bụ atọ akara ọgwụgwọ. ọrịa cancer pancreatic.A kwadoro Erlotinib Hydrochloride na Nọvemba, 2004, maka ọgwụgwọ ọrịa cancer akpa ume dị elu ma ọ bụ metastatic na-abụghị obere cell.Ọ bụ otu klaasị dị ka Gefitinib, quinazoline ọzọ akwadoro maka ọgwụgwọ ọrịa kansa akpa ume dị elu, mana nwere akụrụngwa ọgwụ pharmacokinetic ka mma.Pfizer sitere na molekul a na mmepe malitere na mmekorita ya na OSI, bụ nke were ikike zuru oke maka ọgwụ mgbe Pfizer jikọtara ya na Warner Lambert.N'ikpeazụ, Genentech/Roche batara na nkwekọrịta ikike na OSI iji mepụta na ịzụ ahịa ọgwụ na US na n'ụwa nile.Nhọrọ nke ihe nnabata nke uto epidermal (EGFR) - tyrosine kinase inhibitor.Antineoplastic.Erlotinib Hydrochloride bụ ihe mgbochi HER1/EGFR nwere IC50 nke 2 nM.Erlotinib HCl dị dị ka 25-, 100-, na 150-mg mbadamba mbadamba nchịkwa.