Fmoc-Ile-OH CAS 71989-23-6 Fmoc-L-Isoleucine Dị ọcha> Ụlọ ọrụ 99.0% (HPLC)

Fmoc-L-Isoleucine (Fmoc-Ile-OH) (CAS: 71989-23-6) bụ ihe mgbapụta isoleucine, bụ amino acid na-ekwekọghị n'okike ejiri maka peptidomimetics.Fmoc-L-isoleucine bụ Nα-9-fluorenylmethoxycarbonyl-amino acid.9-fluorenylmethoxycarbonyl bụ ihe dị mkpa amino na-echebe otu na peptide njikọ.N'ihi na ọ bụ ihe nchebe na-eche nche ma kwụsie ike na ọnọdụ ndị a na-eji wepụ otu nchebe nkịtị, ọ nwere ọrụ pụrụ iche na njikọ polypeptide.Ngwongwo ụlọ ọkọlọtọ maka njikọ peptide siri ike na-aga n'ihu na-eso Fmoc-tactics.
Fmoc-amino acid, eji na peptide njikọ, eji dị ka ihe organic synthesis intermediate, pharmaceutical intermediate, biochemical reagent ma ọ bụ kemịkalụ reagent.
Nkwadebe L-Isoleucine (CAS: 73-32-5) 1.05g (0.008 mol) nke siri ike gbazere na 10% sodium carbonate solution, L-isoleucine siri ike gbazere nke ọma site na ịkpali.Na 20 ~ 30 ℃, 9-fluorenylmethoxycarbonyl chloride (205g) etisasịwo na toluene (2 ~ 2.10) agbakwunyere dropwise, 0.008 mol) ngwọta, Dropwise na-agbakwunye 30 ~ 60 nkeji, njedebe nke mgbakwunye, na 20 ~ 30 C na-akpali 1. ~ 8 awa, tinye 30 ~ 200 ml nke mmiri dilution, na n-butyl acetate (80 ml) ngafe 9-fluorenylmethoxycarbonyl chloride wepụrụ site mmịpụta, nke pụtakwara aqueous agba na acidified na concentrated hydrochloric acid na PH = 0.5 ~ 3.5, mgbe ahụ. ewepụtara ya na n-butyl acetate (80 ml), a na-eji mmiri na-asacha mmanụ nke sitere na mmiri iji wepụ hydrochloric acid, a na-etinye oge mmanụ ahụ iji wepụ ihe mgbaze n-butyl acetate, kristal na-acha ọcha na-agbapụta, na-enyocha ma kpọọ nkụ iji nye ngwaahịa ahụ. Fmoc-L-Isoleucine 2.48g, mkpụrụ 87.9%, Ebe mgbaze: 140.0 ~ 155.0 ℃.