Fondaparinux Sodium CAS 114870-03-0 API
Nye ya na ịdị ọcha dị elu yana ịdị mma kwụsie ike
Aha Chemical: Fondaparinux Sodium
Ọnọdụ: 114870-03-0
Antithrombotic Anticoagulant, ihe na-egbochi Xa
API Ogo dị elu, mmepụta azụmahịa
Aha Chemical | Fondaparinux sodium |
Nọmba CAS | 114870-03-0 |
Nọmba CAT | RF-API84 |
Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms |
Usoro ihe omimi | C31H43N3O49S8.10Na |
Ibu molekụla | 1728.08 |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Ọcha ka Gbanyụọ-Ọcha ntụ ntụ |
Usoro nyocha / nyocha | 95.0% ~ 103.0% (na a mịrị amị ndabere) |
Solubility | Soluble na mmiri n'efu, 2.0M Sodium Chloride na 0.5M Sodium Hydroxide na Apụghị Apụ na Ethanol |
njirimara 13C-NMR | Ekwesịrị ịhụ resonances maka Fondaparinux Sodium na 58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 176.7mpp na 176.7mpp.Mgbanwe kemịkalụ nke akara ndị a adịghị iche karịa ± 0.3ppm akara ndị ọzọ nke ịdị elu dị elu na mgbanwe kemịkalụ, nke sitere na Fondaparinux Sodium, enwere ike ịhụ n'etiti 58.0 ~ 80.5 ppm na 98.7 ~ 104.5ppm. |
njirimara HPLC | Oge njide nke nnukwu ọnụ ọgụgụ kachasị elu nke ngwọta nlele dabara na nke ọkọlọtọ ọkọlọtọ |
njirimara AAS | Sodium kwesịrị ịnwe nnabata njirimara na 330.2nm n'okpuru mkpebi nke sodium |
pH | 6.0-8.0 |
Sodium (Na) | 11.5% ~ 15.0% (gbakọọ na anhydrous na ihe mgbaze n'efu) |
Sulfate efu | ≤0.30% |
Chloride fọdụrụnụ | ≤1.00% |
Ihe ndị emetụtara | |
adịghị ọcha A | ≤0.80% |
adịghị ọcha B | ≤0.60% |
Ịdịghị Ọcha Ndị Ọzọ | ≤0.30% |
Mgbakọta adịghị ọcha | ≤2.00% |
Ihe mgbaze fọdụrụnụ | |
Methanol | ≤3000ppm |
Ethanol | ≤5000ppm |
Ethyl acetate | ≤5000ppm |
DMF | ≤880ppm |
Methylbenzene | ≤890ppm |
Pyridine | ≤50ppm |
Ọdịnaya Mmiri (KF) | ≤15.0% |
Endotoxins nke nje bacteria | ≤3.3EU/mg |
Oke Microbial | Ngụkọta ọnụ ọgụgụ microorganisms ≤100cfu/g |
Nlele ọkọlọtọ | Ụkpụrụ ụlọ ọrụ;Ọkọlọtọ United States Pharmacopoeia (USP). |
Ojiji | API, Antithrombotic Anticoagulant, ihe na-egbochi Xa |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
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Fondaparinux Sodium (CAS 114870-03-0) bụ nke mbụ n'ime klas ọhụrụ nke antithrombotic anticoagulant kemịkalụ metụtara heparins dị obere arọ (LMWH).Fondaparinux sodium bụ ihe na-egbochi Xa inhibitor na-etolite saịtị njikọ njikọ dị elu maka ihe mgbochi coagulant antithrombin III (ATIII).Njikọ Fondaparinux sodium na saịtị a na-eme ka mmetụta mgbochi eke sitere na ATIII megide Factor Xa site na ihe dịka 300, nke na-ebute mgbochi nke ọgbọ thrombin.GlaxoSmithKline na-ere ya.A na-ere ụdị ụdị nke Alchemia mepụtara n'ime US site n'aka Dr. Reddy's Laboratories.Ebu ụzọ webatara Fondaparinux sodium na US maka mgbochi nke thrombosis miri emi nke nwere ike ibute mgbakasị akpa ume na-eso nnukwu ịwa ahụ ọkpụkpụ.Ngwakọta molecule sịntetị a kpamkpam bụ nnomi nke usoro heparin pentasaccharide, nke kachasị mkpụmkpụ nwere ike ime ka mgbochi antithrombin llmmediated nke Factor Xa si otú a na-egbochi ọgbọ thrombin na-enweghị ọrụ antithrombin.
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