Fulvestrant (ICI 182780) CAS 129453-61-8 API Ụlọ ọrụ dị elu

Nkọwa dị mkpirikpi:

Aha: Fulvestrant (ICI 182780)

OZI: 129453-61-8

Ọdịdị: White ka Gbanyụọ-White Crystalline ntụ ntụ

Nyocha: 97.0% ~ 102.0% (na mịrị amị)

A na-eji Fulvestrant na-agwọ ọrịa cancer ara na-enwe mmetụta nke hormone na ụmụ nwanyị postmenopausal.

API Ogo dị elu, mmepụta azụmahịa

Inquiry: alvin@ruifuchem.com

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Nkọwa ngwaahịa

Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Nkọwa:

Onye nrụpụta nwere ịdị ọcha dị elu yana ịdị mma kwụsie ike
Aha: Fulvestrant
OZI: 129453-61-8
A na-eji Fulvestrant na-agwọ ọrịa cancer ara na-enwe mmetụta nke hormone na ụmụ nwanyị postmenopausal.
API Ogo dị elu, mmepụta azụmahịa

Njirimara kemịkalụ:

Aha Chemical	Fulvestrant
Ụdị okwu	(7α,17β) -7- [9-[(4,4,5,5,5-Pentafluorpentyl) sulfinyl] nonyl] estra-1,3,5 (10) -trien-3,17-diol;ICI 182780
Nọmba CAS	129453-61-8
Nọmba CAT	RF-API81
Ọnọdụ Ahịa	Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms
Usoro ihe omimi	C32H47F5O3S
Ibu molekụla	606.77
Ebe Na-agbaze	104.0 ~ 106.0 ℃
Solubility	Soluble na methanol, ethanol;Na-adịghị edozi n'ime mmiri
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Ntụ ntụ kristal na-acha ọcha ruo na-agbanyụọ
njirimara	Site na IR, HPLC
Ntụgharị ngwa anya akọwapụtara	+108.0° ruo +115.0°
Ọnwụ na ihicha	≤0.50%
Ihe fọdụrụ na mgbanye	≤0.10%
6-Keto-Fulvestrant	≤0.10%
6,7-Onye na-emezu	≤0.10%
Sulfone nke Fulvestrant	≤0.20%
Fulvestrant gbatịrị	≤0.30%
Sterol dimmer na-eme ihe	≤0.80%
Onye ọ bụla adịghị ọcha akọwapụtaghị	≤0.10%
Mgbakọta adịghị ọcha	≤1.0%
Fulvestrant A	42.0% ~ 48.0%
Fulvestrant B	52.0% ~ 58.0%
DMF	≤620ppm
Ọla dị arọ	≤10ppm
Nyocha	97.0% ~ 102.0% (na akpọnwụwo ndabere)
Nchekwa	Chekwaa n'ụlọ ahịa arịa na-eguzogide ọkụ mechiri emechi nke ọma na friji na 2 ~ 8 ℃
Nlele ọkọlọtọ	Ọkọlọtọ United States Pharmacopoeia (USP).
Ojiji	Onye na-anabata Estrogen

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.

Uru:

Ajụjụ:

Ngwa:

Fulvestrant (ICI-182780) CAS 129453-61-8, bụ ọgwụ ịgba ọgwụ anụ ahụ nke ụlọ ọrụ AstraZeneca mepụtara ma jiri ya na-agwọ ọrịa kansa ara na-enwe mmetụta nke homonụ na ụmụ nwanyị postmenopausal.Fulvestrant bụ naanị ọgwụ antiestrogen nke enwere ike iji ya mee ihe n'ọtụtụ ebe na-eso ọgwụgwọ tamoxifen na-aga nke ọma.Ọgwụ a bụ ụdị ọgwụgwọ endocrine, yabụ na ọ gaghị ebute nsonaazụ ọjọọ ọ bụla a na-ahụkarị na chemotherapy, na-enye ya nnabata ndị ọrịa dị mma.Ọtụtụ ule ụlọ ọgwụ achọpụtala na 250mg Fulvestrant dị irè ma na-echekwa ya dị ka usoro ọgwụgwọ nke abụọ maka ọrịa ara ara dị elu.Fulvestrant bụ onye na-emegide Estrogen na-anabata ya (ER) nke nwere IC50 nke 0.94 nM na nyocha enweghị cell.Fulvestrant na-ebutekwa autophagy na apoptosis ma nwee ọrụ antitumor.