Gemcitabine CAS 95058-81-4 Assay 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta Gemcitabine (CAS: 95058-81-4) nwere oke mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Ịzụta Gemcitabine,Please contact: alvin@ruifuchem.com
| Aha Chemical | Gemcitabine |
| Ụdị okwu | 2'-Deoxy-2',2'-Difluorocytidine;4-Amino-1-[3,3-Difluoro-4-Hydroxy-5- (Hydroxymethyl) oxolan-2-yl] pyrimidin-2-otu;dFDC;Gemzar (Lilly);LY-188011;dFdCyd;DDFC;2',2'-Difluoro-2'-deoxycytidine;2',2'-Difluorodeoxycytidine;Folfugem;GemLip;Gemcel;Gamcitabine |
| Ọnọdụ Ahịa | N'ahịa, Ike nrụpụta 5 Tọn |
| Nọmba CAS | 95058-81-4 |
| CAS metụtara | 122111-03-9 |
| Usoro ihe omimi | C9H11F2N3O4 |
| Ibu molekụla | 263.20 g/mol |
| Ebe Na-agbaze | 217.0 ruo 222.0 ℃ |
| Njupụta | 1.84±0.10 g/cm3 |
| Mmetụta | Okpomọkụ nwere mmetụta |
| Mmiri Solubility | Ihe Na-adịghị Mma Na Mmiri |
| COA & MSDS | Dị |
| Mmalite | Shanghai, China |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta | Nsonaazụ |
| Ọdịdị | White ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha kristal ntụ ntụ, enweghị isi | Na-akwado |
| Cytosine | ≤0.10% | 0.002% |
| α-Isomer | ≤0.10% | 0.01% |
| Ọdịghị ọcha nke Onwe Onye | ≤0.10% | 0.03% |
| Mgbakọta adịghị ọcha | ≤1.00% | 0.10% |
| Mmiri nke Karl Fischer | ≤1.00% | 0.67% |
| Ntụgharị akọwapụtara | +68.0°~+74.0° | + 70.5 ° |
| Ọla dị arọ | ≤10ppm | <10ppm |
| Ihe fọdụrụ na mgbanye | ≤0.10% | 0.03% |
| Nyocha (nke HPLC) | 98.0% ~ 102.0% | 99.9% |
| Spectrum infrared | Nkwekọ na Structure | Na-akwado |
| 1H NMR Spectrum | Nkwekọ na Structure | Na-akwado |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Debe akpa ahụ nke ọma ma debe ya n'ụlọ nkwakọba ihe dị jụụ, kpọrọ nkụ na nke ikuku na-ekpo ọkụ n'ebe ihe na-adabaghị adaba.Zere ikpughe ìhè anyanwụ kpọmkwem, iru mmiri na oke okpomọkụ.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.
Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.
Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.
Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.
Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
Koodu ihe ize ndụ R21 - na-emerụ ahụ na kọntaktị na akpụkpọ ahụ
R36 / 38 - na-akpasu iwe na anya na akpụkpọ ahụ.
R46 - nwere ike ibute mmebi mkpụrụ ndụ ihe nketa
R62 - Ihe ize ndụ nke enweghị ike ịmụ nwa
R63 - ihe ize ndụ nwere ike imerụ nwa e bu n'afọ
Nkọwa nchekwa S25 - Zere kọntaktị na anya.
S26 - N'ihe banyere kọntaktị na anya, kpochaa ozugbo na ọtụtụ mmiri ma chọọ ndụmọdụ ahụike.
S36/37 - Yiri uwe nchebe kwesịrị ekwesị na uwe aka.
S53 - Zere ikpughe - nweta ntuziaka pụrụ iche tupu ejiri ya.
Koodu HS 2934999091
Nsi LD10 iv na oke: 200 mg/m2 (Abbruzzese)
Gemcitabine (CAS: 95058-81-4) bụ ọgwụ chemotherapy eji agwọ ọtụtụ ụdị ọrịa kansa.Nke a na-agụnye ọrịa kansa ara, ọrịa kansa akpa ume na-abụghị obere cell, ọrịa pancreatic, kansa eriri afọ, na ọrịa biliary tract.A na-enyocha Gemcitabine maka iji ya na ọrịa cancer esophageal, a na-ejikwa ya mee nnwale na lymphomas na ụdị ụbụrụ ndị ọzọ dị iche iche.A na-eji Gemcitabine eme ya site na ụzọ intravenous, ebe ọ bụ na akụkụ eriri afọ na-emezi ya nke ukwuu.
Gemcitabine bụ analọgụ nucleotide, nke sitere na klas mgbochi metabolic nke ọgwụ mgbochi ọrịa kansa.Ọ na-emekarị na usoro DNA njikọ, ya bụ, S phase.N'okpuru ọnọdụ ụfọdụ, ọ nwere ike igbochi usoro G1 ịga n'ihu na mpaghara S.O nwere njiri mara nke ụdịdị dị iche iche anticancer, usoro pụrụ iche nke ime ihe, nsi dị ala, enweghị mgbochi mgbochi ọgwụ ọgwụ chemotherapy ndị ọzọ yana enweghị oke nsi.Akwụkwọ kemịkalụ, gemcitabine, ka akwadoro ugbu a maka iji ihe karịrị mba 90, na-eme ka ọ bụrụ ọgwụgwọ mbụ maka ọrịa kansa akpa ume na-abụghị obere cell yana “ọkọlọtọ ọla edo” maka ọrịa kansa pancreatic.
N'afọ 1999, CFDA kwadoro gemcitabine maka ọgwụgwọ NSCLC dị elu ma ọ bụ metastatic, ọrịa cancer pancreatic nke mpaghara ma ọ bụ metastatic;N'afọ 2010, CChemicalbookFDA kwadoro gemcitabine yana paclitaxel maka ọgwụgwọ nke a na-apụghị ịgbagha agbagha, ọrịa cancer ara na-emegharị ugboro ugboro ma ọ bụ metastatic nke maliteghachiri mgbe adjuvant/neoadjuvant chemotherapy.
Gemcitabine bụ antimetabolite sara mbara yana analog deoxycytidine nwere ọrụ antineoplastic.Mgbe nchịkwa gasịrị, a na-atụgharị gemcitabine n'ime metabolites difluorodeoxycytidine diphosphate (dFdCDP) na difluorodeoxycytidine triphosphate (dFdCTP) site na deoxycytidine kinase.dFdCTP na-asọmpi na deoxycytidine triphosphate (dCTP) ma tinye ya na DNA.Nke a na-akpọchi DNA polymerase si otú a na-ebute nkwụsị nkpuchi n'oge mmegharị DNA.N'aka nke ọzọ, dFdCDP na-egbochi ribonucleotide reductase, si otú ahụ na-ebelata ọdọ mmiri deoxynucleotide dị maka njikọ DNA.Mbelata mkpokọta intracellular nke dCTP na-eme ka ntinye nke dFdCTP banye DNA.
