H-Gly-OMe·HCl CAS 5680-79-5 Glycine Methyl Ester Hydrochloride Assay>99.0%

1. Njirimara: Ngwaahịa a kwesịrị ịdị ọcha crystalline ntụ ntụ.
2. Nyocha:
1) Mkpebi nke Glycine Methyl Ester Hydrochloride assay
1.1 Usoro
N'okpuru ọnọdụ acidic, ihe nlele ahụ na-emeghachi omume na ụfọdụ nitrate ọlaọcha, na nitrate ọlaọcha na-abaghị uru na-atụgharị na ammonium thiocyanate, na-ezo aka na ammonium ferric sulfate.
Dị ka ihe na-egosi, a na-ekpebi mkpokọta chlorine dị ka olu nke ọkọlọtọ ọkọlọtọ riri, ma wepụrụ mkpokọta chlorine na ọdịnaya nke glycine hydrochloride iji nweta ọdịnaya Glycine Methyl Ester Hydrochloride.
1.2 Reagent
Dibutyl phthalate;
Ihe ngwọta nitric acid: 2+3;
Ọkọlọtọ titration Silver nitrate: c(AgNO3) = 0.1 mol/L
Ammonium thiocyanate ọkọlọtọ titration ngwọta: c(NH4SCN) = 0.1 mol/L
Ammonium ferric sulfate (III) egosi mmiri mmiri: 80 g/L
1.3 Usoro nyocha
Were ihe dịka 0.5g sample, ziri ezi na 0.0001g.Tinye n'ime iko conical 250ml, gbazee na mmiri 40ml, tinye 10 ml nitric acid solution, Tinye (50 ± 0.02) mL silver nitrate standard titration solution, 3mL ammonium ferric sulfate solution, 4ml dibutyl phthalate, na thiocyanate Ammonium bụ ngwọta titration. titrated ruo mgbe ngwọta bụ ìhè aja aja ma nọgide na-enweghị color for 30 s.
1.4 Ngụkọta nsonaazụ
A na-agbakọ ọnụ ọgụgụ dị nta nke glycine methyl ester hydrochloric acid ọdịnaya w1, nke akọpụtara dị ka%, dabere na nha (1):
w1= (c1V1-c2V2)*M/1000/m * 100-w2 * 1.126 usoro (1)
Ebe:
V1: Olu ọlaọcha nitrate ọkọlọtọ titration ngwọta (ml)
V2: Olu nke ammonium thiocyanate ọkọlọtọ titration ngwọta nke titration riri (ml)
c1: kpọmkwem uru ọlaọcha nitrate ọkọlọtọ titration ngwọta (mol / L)
c2: kpọmkwem uru nke ammonium thiocyanate ọkọlọtọ titration ngwọta (mol / L)
w2: Mpekere oke (%) nke ọdịnaya glycine hydrochloride dị ka akọwara na Nkebi 4.2
M: Molar uka nke glycine methyl ester hydrochloride (g/mol)
1.126: ọnụọgụ mgbanwe nke glycine hydrochloride na Glycine methyl ester hydrochloride.
Achọpụtara uru pụtara mgbako nke nsonaazụ nha abụọ n'otu n'otu dị ka nsonaazụ nha, yana ọdịiche zuru oke n'etiti nsonaazụ nha abụọ ahụ abụghị ihe karịrị 0.05%.
2) Mkpebi nke ọdịnaya glycine hydrochloride
2.1 Usoro
N'iji dimethyl odo dị ka ihe nrịbama, a na-etinye ihe nlele ahụ na ngwọta titrating ọkọlọtọ nke sodium hydroxide, na olu nke ngwọta bụ titrated dị ka oriri nke ọkọlọtọ sodium hydroxide si dị.
Gbakọọ ọdịnaya glycine hydrochloride.
2.2 Reagent
Ọkọlọtọ titration ngwọta nke sodium hydroxide: c (NaOH) = 0.1mol/L
Mmiri mmiri na-egosi Dimethyl edo edo: 10 g/L
2.3 Usoro nyocha
Were ihe dị ka 5.0 g laabu sample, ziri ezi na 0.0001g, n'ime a 200 ml beaker, igbari na 50ml mmiri, tinye 5 tụlee nke dimethyl.
Mmiri mmiri na-egosi odo odo, yana sodium hydroxide ọkọlọtọ titration ngwọta titration ruo mgbe ngwọta sitere na-acha uhie uhie ruo oroma odo bụ ebe njedebe.
2.4 Ngụkọta nsonaazụ
A na-akọwapụta obere akụkụ w2 nke ọdịnaya glycine hydrochloride dị ka % wee gbakọọ dịka nha (2):
w2 = (V/1000) cM/m * 100 usoro (2)
Ebe:
V: Olu sodium hydroxide ọkọlọtọ titration ngwọta (mL)
c: Kpọmkwem uru nke sodium hydroxide ọkọlọtọ titration ngwọta ntinye uche (mol/L)
M: Molar Mass nke glycine hydrochloride (g/mol)
m: Uru oke nke ihe nlele (g)
Achọpụtara ọnụọgụ ọnụọgụ abụọ n'otu n'otu dị ka nsonaazụ nha, yana ọdịiche zuru oke n'etiti nsonaazụ nha abụọ ahụ abụghị ihe karịrị 0.05%
3. Ebe na-agbaze: Dị ka usoro nke ikpebi ebe mgbaze (Chinese Pharmacopoeia 2010 Appendix VIC), ebe mgbaze na-agbaze bụ 172-178 ºC.
4. Ihicha arọ ọnwụ: were ngwaahịa a na 105.0 ℃ ma kpoo ya ka ọ dị arọ mgbe niile.Mbelata arọ agaghị agafe 0.5%.
5. Nchekwa: Ngwaahịa a kwesịrị ka etinye ya na friji pụọ na ìhè.