Ibrutinib Deacryloylpiperidine CAS 330786-24-8 Ịdị ọcha>99.0% (HPLC)
Aha Chemical | 3- (4-Phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidin-4-amine |
Ụdị okwu | Ibrutinib intermeidate N-2;Ibrutinib Deacryloylpiperidine;Ibrutinib adịghị ọcha 8;5- (4-Phenoxyphenyl) -7H-pyrrolo [2,3-d] pyrimidin-4-ylamine;IBT4A;Ibrutinib N-Despiperidinyl adịghị ọcha |
Nọmba CAS | 330786-24-8 |
Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
Usoro ihe omimi | C17H13N5O |
Ibu molekụla | 303.32 |
Ebe Na-agbaze | > 262 ℃ (Dec.) |
Njupụta | 1.380±0.06 g/cm3 |
Klas Hazard | 6.1;Nsi |
Otu nkwakọ ngwaahịa | III |
COA & MSDS | Dị |
Mmalite | Shanghai, China |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Gbanyụọ-White ka Khaki ntụ ntụ |
njirimara | HNMR, LC-MS |
Ụzọ ịdị ọcha / nyocha | > 99.0% (HPLC) |
Ọnwụ na ihicha | <1.00% |
Otu Max.adịghị ọcha | <1.00% |
Mgbakọta adịghị ọcha | <1.00% |
Ọla dị arọ (dị ka Pb) | <20ppm |
Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
Ojiji | Ọkara nke Ibrutinib (CAS: 936563-96-1) |
ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri.
3- (4-Phenoxyphenyl) -1H-pyrazolo [3,4-d] pyrimidin-4-amine (CAS: 330786-24-8) bụ etiti synthetic bara uru na njikọ nke Ibrutinib (CAS: 936563-96-1). ).Ibrutinib bụ ụdị Bruton tyrosine kinase (BTK) inhibitor, enwere ike iji ya maka ọgwụgwọ ọrịa leukemia lymphocytic na-adịghị ala ala (CLL) na lymphoma mantle cell (MCL).MCL na CLL bụ nke B-cell na-abụghị Hodgkin's lymphoma, nke siri ike ịgwọ ma dị mfe ịmaliteghachi.Immunotherapy kemịkalụ a na-ahụkarị enweghị ebumnuche, na-emekarị mmeghachi omume ọjọọ 3 ma ọ bụ 4.Ibrutinib na B lymphocytes nwere ike ilekwasị anya na BTK bụ nke dị mkpa maka nhazi, ọdịiche, na nnyefe ozi, na-egbochi ọrụ BTK na-agbanwe agbanwe, na-egbochi mmụba cell tumor na nlanarị nke ọma.Ibrutinib nwere ike itinye uche ngwa ngwa mgbe nchịkwa ọnụ gasịrị, n'oge 1 ~ 2h ruru oke ntinye ọbara, mmeghachi omume ọjọọ bụ otu ma ọ bụ abụọ, ya mere, Ibrutinib ga-aghọ nhọrọ ọhụrụ nke ọgwụgwọ CLL na MCL.