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N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Cleanity Featured Image
  • N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity

N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity

Nkọwa dị mkpirikpi:

Aha: N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea

Synonyms: Imatinib Mesylate Intermediate

Ọnọdụ: 152460-10-1

Ọdịdị: Orange Light Ka Yellow Powder ruo Crystal

Ịdị ọcha: ≥98.0% (HPLC)

Otiti nke Imatinib Mesylate (CAS: 220127-57-1) na ọgwụgwọ nke Philadelphia Chromosome-Positive Chronic Myeloid Leukemia (Ph + CML)

Inquiry: alvin@ruifuchem.com


Nkọwa ngwaahịa

Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Nkọwa:

Mbubata Azụmahịa Imatinib Mesylate na ihe ndị metụtara ya:
Imatinib Mesylate CAS: 220127-57-1
N- (2-Methyl-5-nitrophenyl)-4- (pyridin-3-yl) pyrimidin-2-amine CAS: 152460-09-8
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl) methyl] benzoic acid dihydrochloride CAS: 106261-49-8

Njirimara kemịkalụ:

Aha Chemical N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea.
Ụdị okwu Imatinib Mesylate Intermediate;2- (5-Amino-2-methylanilino) -4- (3-pyridyl) pyrimidine.
Nọmba CAS 152460-10-1
Nọmba CAT RF-PI230
Ọnọdụ Ahịa N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi C16H15N5
Ibu molekụla 277.32
Ebe Na-agbaze 133.0-135.0 ℃
Ụdị Ruifu Chemical

Nkọwapụta:

Ihe Nkọwapụta
Ọdịdị Orange Ìhè ka ntụ ntụ odo ruo kristal
Ụzọ ịdị ọcha / nyocha ≥98.0%
Ọnwụ na ihicha ≤0.50%
Ihe fọdụrụ na mgbanye ≤0.50%
Mgbakọta adịghị ọcha ≤2.0%
Oke adịghị ọcha otu ≤1.0%
Ọla dị arọ ≤20ppm
Nlele ọkọlọtọ Standardkpụrụ ụlọ ọrụ
Ojiji Ọkara nke Imatinib Mesylate (CAS: 220127-57-1)

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe pụọ na ọkụ, mmiri mmiri na ọrịa nje.

Uru:

1

Ajụjụ:

Ngwa:

Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta ihe na onye na-ebubata N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea (CAS: 152460-10-1) nwere oke mma. .
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea (CAS: 152460-10-1) bụ nke etiti na-emekarị na njikọ nke Imatinib Mesylate (CAS: 220127-57-1). ) API.
Imatinib mesylate bụ obere molekul nke na-egbochi c-Abl protein-tyrosine kinase, kinase dị mkpa maka mmụba nke leukemia myelogenous na-adịghị ala ala (CML).Ihe omume ntụgharị n'etiti chromosomes 9 na 22 na-emepụta chromosome Philadelphia, nke na-emepụta protein Bcr-Able fusion na ọrụ kinase aberrant nke na-akwalite mgbasawanye cell ngwa ngwa.Imatinib mesylate na-ejikọta kinase a dị mkpa, na-akwụsị uto metụtara CML.Imatinib mesylate ka egosiputala iji gbochie PDGFR na tyrosine kinases jikọtara ya na c-Kit.A na-eji usoro ndị nwere Imatinib mesylate mee ihe n'ịgwọ ọrịa cancer dị iche iche.
Imatinib mesylate bụ ihe mgbochi tyrosine kinase.Nke a kapịrị ọnụ maka BCR-ABL, enzyme jikọtara ya na ọrịa leukemia myelogenous na-adịghị ala ala (CML) na ụdị ụfọdụ nke nnukwu ọrịa leukemia lymphoblastic (ALL).Ọ bụ v-Abl tyrosine kinase inhibitor nke nwere ike na nhọrọ (IC50 = 38 nM).Na-egbochikwa PDGFR na c-kit.Na-egosipụta nhọrọ maka v-Abl n'elu panel nke tyrosine ndị ọzọ na serine/threonine protein kinases.Nhọrọ na-egbochi uto PDGF-akpali akpali nke mkpụrụ ndụ PB-3 v-abl gbanwere na sel BALB/c 3T3 v-sis gbanwere na vitro.Na-egosiputa mmetụta antitumor na ụmụ oke na-ebu AMuLV ma ọ bụ sel BABL/c 3T3 v-sis.Na-egbochi mmegharị nke SARS-CoV na MERS-CoV in vitro (ụkpụrụ EC50 bụ 9.823 na 17.689 μM, n'otu n'otu).

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