Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Factory High Quality
Mbubata Azụmahịa Imatinib Mesylate na ihe ndị metụtara ya:
Imatinib Mesylate CAS: 220127-57-1
N- (2-Methyl-5-nitrophenyl)-4- (pyridin-3-yl) pyrimidin-2-amine CAS: 152460-09-8
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl) methyl] benzoic acid dihydrochloride CAS: 106261-49-8
| Aha Chemical | Imatinib Mesylate (ụdị alfa) |
| Ụdị okwu | Imatinib methanesulfonate;STI571 Mesylate;CGP-57148B |
| Nọmba CAS | 220127-57-1 |
| Nọmba CAT | RF-API19 |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C30H35N7O4S |
| Ibu molekụla | 589.71 |
| Ọnọdụ mbupu | N'okpuru ọnọdụ okpomọkụ |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ntụ ntụ kristal na-acha ọcha ruo na-agbanyụọ |
| Solubility | Ọ dị mfe igbari na mmiri |
| HPLC njirimara | Oge njigide kacha elu nke ụdịdị dị iche iche dabara na nke ahụ |
| Nchọpụta IR | Infrared absorption ụdịdị dị iche iche nke sample kwekọrọ na ntụnyere sample |
| Ebe Na-agbaze | 214.0 ~ 222.0 ℃ |
| Ọnwụ na ihicha | ≤0.50% |
| Ihe fọdụrụ na mgbanye | ≤0.10% |
| Ọla dị arọ | ≤20ppm |
| Ihe ndị emetụtara | (1) adịghị ọcha G: NMT 0.3% |
| (2) adịghị ọcha B: NMT 0.3% | |
| (3) adịghị ọcha C: NMT 0.3% | |
| (4) adịghị ọcha D: NMT 0.3% | |
| (5) adịghị ọcha A: NMT 0.3% | |
| (6) adịghị ọcha H: NMT 0.3% | |
| (7) adịghị ọcha F: NMT 0.3% | |
| (8) adịghị ọcha E: NMT 0.3% | |
| (9) Nnukwu otu adịghị ọcha: NMT0.1% | |
| Ihe mgbaze fọdụrụnụ | (1) Ethyl Acetate: NMT 5000ppm |
| (2) methanol: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ethanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| HPLC nyocha | 98.0% ~ 102.0% (C30H35N7SO4 gbakọrọ na Anhydrous ndabere) |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | API;Ph+CML |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Imatinib Mesylate (CAS 220127-57-1) bụ obere molekul na-egbochi c-Abl protein-tyrosine kinase, kinase nke dị mkpa maka mmụba nke leukemia myelogenous na-adịghị ala ala (CML).Nke a kapịrị ọnụ maka BCR-ABL, enzyme jikọtara ya na ọrịa leukemia myelogenous na-adịghị ala ala (CML) na ụdị ụfọdụ nke nnukwu ọrịa leukemia lymphoblastic (ALL).Ọ bụ v-Abl tyrosine kinase inhibitor nke nwere ike na nhọrọ (IC50 = 38 nM).Ihe omume ntụgharị n'etiti chromosomes 9 na 22 na-emepụta chromosome Philadelphia, nke na-emepụta protein Bcr-Able fusion na ọrụ kinase aberrant nke na-akwalite mgbasawanye cell ngwa ngwa.Imatinib mesylate na-ejikọta kinase a dị mkpa, na-akwụsị uto metụtara CML.Imatinib mesylate ka egosiputala iji gbochie PDGFR na tyrosine kinases jikọtara ya na c-Kit.
![4-[(4-Methylpiperazin-1-yl) methyl] benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)