Irbesartan CAS 138402-11-6 Ịdị Ọcha>99.0% (HPLC) API Ụlọ ọrụ mgbochi ọbara mgbali elu
Onye na-emepụta ihe, ịdị ọcha dị elu, mmepụta azụmahịa
| Aha Chemical | Irbesartan |
| Ụdị okwu | BMS-186295;SR-47436;Aprovel;Avapro;2-Butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4] na-abụghị 1-en- 4-otu;2-Butyl-3-[[4-[2- (2H-tetrazol-5-yl) phenyl] phenyl] methyl] -1,3-diazaspiro [4.4] na-abụghị 1-en-4-otu |
| Nọmba CAS | 138402-11-6 |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C25H28N6O |
| Ibu molekụla | 428.54 |
| Njupụta | 1.30±0.10 g/cm3 |
| Solubility na Mmiri | Na-adịghị edozi n'ime mmiri |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Njirimara | Ntụ ntụ kristal na-acha ọcha ruo na-acha ọcha, na-agbaze ntakịrị n'ime mmanya na methylene chloride, ọ fọrọ nke nta ka ọ bụrụ ihe a na-esighị ike na mmiri. |
| Identification absorption infrared | Ụdị ụdịdị IR dị n'ụdị ụdịdị dị iche iche enwetara na Irbesartan RS |
| njirimara 2 | Oge njide nke isi kacha elu na chromatogram nke nyocha ahụ kwekọrọ na Irbesartan RS |
| Ụzọ ịdị ọcha / nyocha | > 99.5% (HPLC) |
| Mmiri | <0.50% |
| Ọla dị arọ | <0.002% |
| Ihe fọdụrụ na mgbanye | <0.10% |
| Ihe ndị emetụtara | (nke HPLC) |
| USP adịghị ọcha A | <0.20% |
| Ọdịghị ọcha ọ bụla amabeghị | <0.10% |
| Mgbakọta adịghị ọcha | <0.50% |
| Organic VolatileImpurities | Zutere ihe achọrọ nke USP |
| Azide fọdụrụnụ | <10ppm |
| Ihe mgbaze fọdụrụnụ | (site na GC) |
| Ethanol | <5000ppm |
| Toluene | <890ppm |
| Dichloromethane | <3000ppm |
| N, N-Dimethylformamide | <880ppm |
| T-Butyl Methyl Ether | <5000ppm |
| Nyocha | 98.0 ~ 102.0% (gbakọọ na anhydrous ndabere) |
| Nlele ọkọlọtọ | Ụkpụrụ ụlọ ọrụ;USP Standard |
| Ojiji | API;antihypertensive;Maka ọgwụgwọ ọbara mgbali elu |
ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri
Irbesartan (CAS: C) bụ angiotensin II nnabata antagonist eji tumadi maka ọgwụgwọ ọbara mgbali elu.Emepụtara Irbesartan site na Sanofi Research (nke bụ akụkụ Sanofi-Aventis ugbu a).Sanofi-Aventis na Bristol-Myers Squibb jikọrọ aka na-ere ya n'okpuru aha azụmaahịa Aprovel, Karvea na Avapro.A na-eji Irbesartan agwọ ọbara mgbali elu.A malitere Avapro na Germany, UK na US maka ọbara mgbali elu.Dị ka ọ dị na ndị na-anabata angiotensin II niile, a na-egosi irbesartan maka ọgwụgwọ ọbara mgbali elu.Irbesartan nwekwara ike igbu oge n'ihu nke nephropathy na-arịa ọrịa shuga ma gosipụtakwa ya maka mbelata ọrịa gbasara akụrụ na ndị ọrịa nwere ụdị ọrịa shuga 2, ọbara mgbali elu na microalbuminuria (> 30 mg / awa 24) ma ọ bụ proteinuria.Irbesartan nwekwara ike ibelata mmezigharị eletriki nke myocardium, si otú ahụ belata ọnụ ọgụgụ ndị ọrịa nwere ọbara mgbali elu na-anwụ anwụ, ọ bụ ọgwụ kachasị dị irè maka ọgwụgwọ ọbara mgbali elu na ọrịa obi.
