Irinotecan Hydrochloride CAS 100286-90-6 Ịdị Ọcha ≥99.0% (HPLC) API USP Standard High ịdị ọcha
| Aha Chemical | Irinotecan Hydrochloride |
| Ụdị okwu | Camptothecin II;CPT-II |
| Nọmba CAS | 100286-90-6 |
| Nọmba CAT | RF-API50 |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C33H39ClN4O6 |
| Ibu molekụla | 623.15 |
| Ebe Na-agbaze | 250-256 ℃ (Dec.) |
| Ọnọdụ Nchekwa | N'okpuru ọnọdụ okpomọkụ |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ọcha ma ọ bụ Gbanyụọ-Ọcha ntụ ntụ |
| Solubility | Soluble na mmiri na methanol, soluble ntakịrị na chloroform, ethanol |
| njirimara IR | Ụdị nnabata infrared nke nlele ule kwesịrị ikwekọ na nke ọkọlọtọ ntụaka |
| njirimara HPLC | Oge njide nke isi kacha elu nke ngwọta nlele kwesịrị ikwekọ na nke ọkọlọtọ ntụaka. |
| njirimara | Na-emezu ihe achọrọ maka ule maka mmeghachi omume ọma Chloride |
| Mmiri (KF) | 7.0% ~ 9.0% w/w |
| Ihe fọdụrụ na mgbanye | ≤0.10% |
| Ọla dị arọ | ≤20ppm |
| Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
| 7-Desethyl Irinotecan | ≤0.15% |
| Ihe jikọrọ Irinotecan A | ≤0.15% |
| 11-Ethyl Irinotecan | ≤0.15% |
| Camptothecin | ≤0.15% |
| Ihe jikọrọ Irinotecan B | ≤0.15% |
| 7-Ethylcanptothecin | ≤0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
| Ọdịghị ọcha ọ bụla akọwapụtaghị | ≤0.10% |
| Mgbakọta adịghị ọcha | ≤0.50% |
| Ihe mgbaze fọdụrụnụ (GC) | |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| Dichloromethane | ≤500ppm |
| Peteoleum Ether: | ≤100ppm |
| Ethyl acetate | ≤2000ppm |
| Benzene | ≤2pm |
| Endotoxins nke nje bacteria | ≤0.29 EU/mg Irinotecan |
| Oke Microbial | Ngụkọta ọnụ ọgụgụ microbial nke ikuku: <1000 cfu/g |
| Ebu na yist | <100 cfu/g |
| Ụzọ ịdị ọcha / nyocha | ≥99.0% (HPLC, na anhydrous ndabere) |
| Nlele ọkọlọtọ | Ọkọlọtọ United States Pharmacopeia (USP). |
| Ojiji | Ngwakọta ọgwụ na-arụ ọrụ (API) |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
lrinotecan hydrochloride (CAS 100286-90-6), ihe na-emepụta ihe na-emepụta mmiri na-emepụta ihe na-emepụta ihe na-eme ihe ike anticancer camptothecin, na Japan maka ọgwụgwọ nke ngụgụ, ovarian, na ọrịa cancer cervical.lrinotecan na-arụ ọrụ antitumor ya site na mgbochi nke topoisomerase I, enzyme cellular nke na-etinye aka n'ịkwado usoro nhazi nke DNA n'oge usoro ntụgharị, ntụgharị, na mitosis.lrinotecan na-enweta de-esterification na vivo iji mepụta metabolite na-arụ ọrụ, SN-38, nke nwere ike 1000 ugboro karịa nne na nna.Ngwọta ọgwụgwọ nke irinotecan na ọgwụ mgbochi ọrịa cancer ọzọ a na-ejikarị eme ihe, bụ cisplatin, ka akọọrọ na ọ dị elu karịa nke ọ bụla naanị ya.lrinotecan nọ na nnwale ụlọ ọgwụ maka eriri afọ, ara, akpụkpọ anụ, colorectal, ọrịa cancer pancreatic, mesothelioma na lymphoma na-abụghị Hodgkin.
