Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API Ụlọ ọrụ dị ọcha dị elu
| Aha Chemical | Irinotecan Hydrochloride Trihydrate |
| Ụdị okwu | Irinotecan HCl Trihydrate;CPT-11 trihydrate;Irinotecan HCL 3H2O |
| Nọmba CAS | 136572-09-3 |
| Nọmba CAT | RF-API52 |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C33H38N4O6·HCl·3H2O |
| Ibu molekụla | 677.20 |
| Ebe Na-agbaze | 250.0 ~ 256.0 ℃ (dc.) |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ntụ ntụ kristal na-acha odo odo ma ọ bụ odo odo |
| Nyocha (w/w) | 98.0% ~ 102.0% |
| Ịdị ọcha (HPLC) | ≥99.5% |
| Solubility | Na-agbaze ntakịrị n'ime mmiri, ethanol ma ọ bụ chloroform, na-adịghị edozi ya na acetone. |
| njirimara | site na IR na HPLC, kwadoro |
| Ntụgharị ngwa anya akọwapụtara | + 60°~+73° |
| Mmiri | 7.0% ~ 9.0% |
| Ihe fọdụrụ nke ihe mgbaze | Na-akwado ihe ICH chọrọ |
| Ihe fọdụrụ na mgbanye | ≤0.20% |
| Chloride | 5.0% ~ 6.0% |
| Uru pH | 3.0-5.0 |
| Ọla dị arọ | ≤20ppm |
| Ihe adịghị ọcha nke onye | ≤0.10% |
| Mgbakọta adịghị ọcha | ≤0.50% |
| Ọnọdụ Nchekwa | Chekwaa na 2-8 Celsius C, n'ime arịa ndị mechiri emechi ma chebe ọkụ na mmiri |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | Ngwakọta ọgwụ na-arụ ọrụ (API) |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Shanghai Ruifu Chemical Co., Ltd. bụ onye na-emepụta ihe na onye na-ebubata Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) nwere àgwà dị elu.
Irinotecan Hydrochloride Trihydrate bụ topoisomerase I inhibitor nke a na-ejikarị agwọ ọrịa kansa eriri afọ na ọrịa kansa ike, na-egbochi religation nke eriri DNA site na ijikọ topoisomerase I-DNA complex.lrinotecan hydrochloride, nke ọkara sịntetik, mmiri na-amịpụta mmiri nke onye na-ahụ maka anticancer camptothecin, ka ewepụtara na Japan maka ọgwụgwọ ọrịa cancer akpa ume, ovarian, na cervical.lrinotecan na-arụ ọrụ antitumor ya site na mgbochi nke topoisomerase I, enzyme cellular nke na-etinye aka n'ịkwado usoro nhazi nke DNA n'oge usoro ntụgharị, ntụgharị, na mitosis.lrinotecan na-enweta de-esterification na vivo iji mepụta metabolite na-arụ ọrụ, SN-38, nke nwere ike 1000 ugboro karịa nne na nna.Ọ bụ ezie na ọ bụ obere ihe na-egbu egbu karịa camptothecin, ọnụ ọgụgụ dị ukwuu nke ndị ọrịa na-anwale ule ụlọ ọgwụ gosipụtara mmetụta dị n'akụkụ leukopenia, afọ ọsịsa, ọgbụgbọ, na alopecia.Ngwọta ọgwụgwọ nke irinotecan na ọgwụ mgbochi ọrịa cancer ọzọ a na-ejikarị eme ihe, bụ cisplatin, ka akọọrọ na ọ dị elu karịa nke ọ bụla naanị ya.lrinotecan nọ na nnwale ụlọ ọgwụ maka eriri afọ, ara, akpụkpọ anụ, colorectal, ọrịa cancer pancreatic, mesothelioma na lymphoma na-abụghị Hodgkin.
