Ketorolac CAS 74103-06-3 Ịdị ọcha> 98.5% (HPLC)

Ketorolac (CAS: 74103-06-3) bụ ihe na-abụghị steroid analgesic na mgbochi mkpali ọgwụ, a na-emepụta pyrrolidone. Usoro kemịkalụ na pharmacological omume yiri Tolectin, Zoaesthetic acid na Indometacin.Site na igbochi cyclooxygenase, ọ na-egbochi njikọ na ntọhapụ nke prostaglandins, na-emepụta mmetụta mgbochi mkpali.Ọ nwere ike belata okpomọkụ nke sitere na isi iyi ọkụ, nke metụtara igbochi njikọ nke prostaglandin na sistemu ụjọ nke etiti. Ọ nwere analgesic siri ike na nke na-agafeghị oke mgbochi mkpali antipyretic na mgbochi nke nchịkọta platelet, ọ nweghịkwa ihe mgbochi nke iku ume na ume. riri ahụ.N'ime nnwale anụmanụ, mmetụta analgesic dị ike karịa aspirin, indomethacin na naproxen. Ọ hà nhata ma ọ bụ dị mma karịa mmetụta mgbochi mkpali nke naproxen na indomethacin, phenylbutazone, mmetụta antipyretic ya na oke dị ike karịa aspirin na phenylbutazone na otu ihe ahụ. Indomethacin na naproxen. Ọ na-egbochi nchịkọta platelet nke arachidonic acid na collagen kpatara.Mana ọ naghị egbochi nnabata nke adenosine diphosphate (ADP).Ngwaahịa a na-etinye ngwa ngwa na kpamkpam kpamkpam mgbe ịgba ọgwụ mgbochi intramuscular gasịrị, ọ fọrọ nke nta ka ọ bụrụ kpamkpam mgbe nchịkwa ọnụ gasịrị. Nri nwere ike belata ọsọ nke absorption, ma ọ dịghị emetụta ogo nke absorption, na bioavailability bụ 80% ~ 100%.Nkeji 10 ka ịgbanye ọgwụ intramuscular nke 30mg, ọ na-ebelata ihe mgbu n'ụzọ doro anya.Mgbe nkeji 50 gachara, ọnụ ọgụgụ kacha elu nke itinye uche na plasma bụ 2.2 g / ml.Mgbe 30 ~ 60 nkeji nke nchịkwa ọnụ, a na-ebelata ihe mgbu ahụ na ntinye uche nke plasma dị elu na 1.5 ruo 4 awa.Ọkara ndụ plasma nke ndị na-eto eto bụ ihe dị ka awa 5.3, na ndị agadi ọ bụ ihe dị ka awa 7, a pụkwara ịnọgide na-enwe mmetụta analgesic maka awa 6 ~ 8.A ga-ewepụ 91.4% site na urinary tract, ndị ọzọ ga-esi na excrement. N'ime ndị ọrịa na-arịa ọrịa akụrụ, mkpokọta mkpochapụ plasma na-ebelata ma ọkara ndụ na-agbatị, ya mere, a ga-ebelata dose ahụ.

Ngwa ụlọ ọgwụ: A na-eji Ketorolac eme ihe maka ọgwụgwọ mgbu na-adịru nwa oge gụnyere mgbu mgbe ịwachara ahụ (dị ka afọ, obi, Urology, gynecology, Department of Stomatology, orthopedic surgery and mgbu) yana nnukwu mgbu akwara skeletal kpatara n'ihi ihe dị iche iche. dị ka mgbakasị ahụ, nkwụsịtụ, mgbaji na mmerụ ahụ dị nro, na ihe mgbu ndị ọzọ nke ọrịa ndị ọzọ kpatara, dị ka mgbu mgbe ọmụmụ nwa, nnukwu renal colic, eze mgbu, sciatica, ọrịa cancer n'oge, mgbu ọnya, biliary colic, wdg .. Enwere ike iji ya mee ihe. dị ka nnọchi nke morphine na pethidine.