L-Alaninamide Hydrochloride CAS 33208-99-0 (H-Ala-NH2·HCl) Nyocha 98.0 ~ 102.0% Safinamide Intermediate Factory

A na-eji L-Alaninamide Hydrochloride (H-Ala-NH2 · HCl) (CAS: 33208-99-0) dị ka ndị na-ahụ maka ọgwụ.A na-eji L-Alaninamide Hydrochloride maka nkwadebe nke akwụkwọ akụkọ amide sitere na ogige steroidal [3,2-c] pyrazole na ọrụ glucocorticoid.L-Alaninamide Hydrochloride bụ etiti Safinamide (CAS: 133865-89-1) na Safinamide Mesylate (CAS: 202825-46-5).Safinamide bụ onye na - ahọrọ ma na - emegharị emegharị nke monoamine oxidase B (MAO-B, IC50 = 98 nM nwere ihe karịrị 100-fold selectivity n'elu MAO-A. Na-egosiputa ọrụ anticonvulsant ma na-echebe ọdịdọ nke kainate na-akpata na neurodegeneration hippocampal na ụdị oke. Ngosipụta glutamatergic karịrị akarị site na mgbochi ọwa sodium na-adabere na ya, ọgwụgwọ ọhụụ maka ọrịa ọrịa Parkinson nwere ụdị omume dị iche iche. Dị irè dị ka mgbakwunye na ọgwụgwọ agonist dopamine na mbido Parkinson. Safinamide methanesulfonate ka EMA kwadoro na February 2015 maka ọgwụgwọ Nnwapụta a gụnyere iji ọgwụ ahụ dị ka ọgwụgwọ mgbakwunye maka ojiji ya na Levodopa, ma ọ bụ naanị ya ma ọ bụ yana yana usoro ọgwụgwọ ndị ọzọ dị maka ọrịa Parkinson. Farmmalia Carlo Erba chọtara na mbụ ma mesịa mepụta Newron/Zambon, na-arụ ọrụ dị ka onye na-emechi ihe na-ahọrọ nke ukwuu na nke na-agbanwe agbanwe nke MAO-B, na-eduga n'ọkwa dopamine na mmụba na-esote na mgbaàmà moto nke ọrịa Parkinson, mmetụta ndị na-emekarị na-esite na ya. iji ọgwụgwọ ọdịnala ndị ọzọ na-adabere na ọgwụgwọ nnọchi dopamine.