L-tert-Leucinol CAS 112245-13-3 Ịdị ọcha> Ụlọ ọrụ 99.0% (HPLC)

L-tert-Leucinol (CAS: 112245-13-3), enwere ike iji ya mee ihe na njikọ peptide, ụdị mmeghachi omume: ngwọta peptide synthesis.Enwere ike iji ya dị ka ihe nkwekọ nke organic, etiti ọgwụ, reagent biochemical ma ọ bụ reagent kemịkalụ.Amino acid bara uru na-arụ ọrụ na mmeghachi omume asymmetric dị iche iche.
Enwere ike nweta L-tert-Leucinol site na ibelata otu carboxyl sitere na L-tert-leucine.Enwere ike ịhọrọ onye na-ebelata ihe site na sodium borohydride na lithium tetrahydroaluminum.
Nkwadebe tinye (83.04g,4eq) sodium borohydride, 2L nke a mịrị amị tetrahydrofuran, L-tert-Leucine 120g n'ime flask ọnụ atọ 5L.N'okpuru nchebe nke balloons nitrogen, 760mL nke 4 hydrofuran ngwọta nke ayodiin (231g,1eq) na-eji nwayọọ nwayọọ na-adaba na ice bat na 0 ℃ iji mee ka ọ meghachi omume n'ụzọ zuru ezu.Mgbe ị na-adaba ma na-akpali ruo mgbe ọ dịghị gas na-ahapụ, wee kpoo ọkụ na reflux maka awa 18, dị jụụ na ụlọ okpomọkụ, ma jiri nwayọọ nwayọọ tinye 300ml nke methanol iji dokwuo anya ngwakọta.Mee ka 30min wepụ ihe na-acha ọcha site na ihe mgbaze, wee gbazee ya na 800mL 20% KOH.Na ngwọta.A na-akpali ihe ngwọta okpomọkụ nke ime ụlọ maka 4h, wee wepụ ya na 1.5L dichloromethane ugboro 3 n'oge ọ bụla, a na-ejikọta akụkụ nke organic, na-asa ya na mmiri nnu jupụtara na mmiri, nke a mịrị amị na sodium sulfate na-ekpo ọkụ ma tinye uche site na ikpo ọkụ iji nweta mkpụrụ 97g ọcha nke ọkara siri ike. 90%