LCZ696 Intermediate CAS 1426129-50-1 Ịdị ọcha ≥98.0% (HPLC) nke ≥99.0% Ụlọ Ọrụ Dị Ọcha
Nbunye azụmaahịa LCZ696 (CAS: 936623-90-4) Mgbakọ emetụtara:
(R) -tert-Butyl (1- ([1,1-biphenyl] -4-yl) -3-hydroxypropan-2-yl) carbamate CAS: 1426129-50-1
(R, E) -5- (1,1'-biphenyl-4-yl) -4- ((tert-butoxycarbonyl) amino) -2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S) -5- (1,1'-biphenyl-4-yl) -4- ((tert-butoxycarbonyl) amino) -2-methylpentanoic acid CAS: 1012341-50-2
(2R, 4S) -ethyl 5- (1,1'-biphenyl-4-yl) -4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium nnu) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Ntinye;Ngwakọta Sacubitril na Valsartan CAS: 936623-90-4
| Aha Chemical | (R) -tert-Butyl (1- ([1,1-biphenyl] -4-yl) -3-hydroxypropan-2-yl) carbamate |
| Ụdị okwu | Ọkara LCZ696 |
| Nọmba CAS | 1426129-50-1 |
| Nọmba CAT | RF-PI169 |
| Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilogram |
| Usoro ihe omimi | C20H25NO3 |
| Ibu molekụla | 327.42 |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ọcha ka Gbanyụọ-Ọcha ntụ ntụ |
| Ụzọ ịdị ọcha / nyocha | ≥98.0% (HPLC) |
| Enantiomeric ngafe | ee: ≥99.0% |
| Mmiri (KF) | ≤1.0% |
| Ihe ndị emetụtara A | ≤1.0% (RRT=0.5) A=(R) -3-([1,1'-biphenyl] -4-yl) -2-aminopropan-1-ol |
| Ihe ndị emetụtara B | ≤1.0% (RRT=0.85) B=Triphenylphosphine oxide |
| Ihe ndị ọzọ | ≤1.0% |
| Mgbakọta adịghị ọcha | ≤2.0% |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | Ọkara nke LCZ696 (CAS: 936623-90-4) na ọgwụgwọ HFrEF |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe pụọ na ọkụ, mmiri mmiri na ọrịa nje.
Onye nrụpụta nwere ịdị ọcha dị elu yana ịdị mma kwụsie ike
Nbunye azụmaahịa LCZ696 (CAS: 936623-90-4) Mgbakọ emetụtara:
(R) -tert-Butyl (1- ([1,1-biphenyl] -4-yl) -3-hydroxypropan-2-yl) carbamate CAS: 1426129-50-1
(R, E) -5- (1,1'-biphenyl-4-yl) -4- ((tert-butoxycarbonyl) amino) -2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S) -5- (1,1'-biphenyl-4-yl) -4- ((tert-butoxycarbonyl) amino) -2-methylpentanoic acid CAS: 1012341-50-2
(2R, 4S) -ethyl 5- (1,1'-biphenyl-4-yl) -4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (hemicalcium nnu) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Ntinye;Ngwakọta Sacubitril na Valsartan CAS: 936623-90-4
LCZ696 bụ ọgwụ nnwale nke Novartis Pharmaceutical nke United States mepụtara maka ọgwụgwọ ndị ọrịa nwere nkụda mmụọ obi nwere mbelata ejection Fraction (HFrEF).Obi mgbawa bụ ọrịa na-eyi ndụ egwu.Obi onye ọrịa enweghị ike ịgbanye ọbara zuru oke iji nye ahụ ahụ, wee pụta ihe mgbaàmà nke dyspnea, ike ọgwụgwụ na njigide mmiri nwayọ nwayọ, wee jiri nwayọ na-abawanye, na-emetụta ogo ndụ.LCZ696 nwere ike ịkwalite nchebe anụ ahụ nke anụ ahụ megide nkụda obi, yana ịbawanye ọkwa nke peptides natriuretic na peptides ndị ọzọ na-akpata vasoactive, na-egbochi usoro renin-angiotensin-aldosterone (RAAS).LCZ696 jikọtara ya na Novartis's Hypertension Medicine (Diovan, generic name: valsartan) na ọgwụ nnwale AHU-377.AHU377 na-egbochi usoro nke peptides abụọ na-ahụ maka ibelata ọbara mgbali.Diovan na-eme ka vasodilatation dịkwuo mma ma na-akpali ahụ ịpụpụ sodium na mmiri.
