Lenvatinib Mesylate Intermediate CAS 15568-85-1 Ịdị Ọcha>97.0% (HPLC) Foto egosipụtara

Lenvatinib Mesylate Intermediate CAS 15568-85-1 Dị Ọcha> Ụlọ ọrụ 97.0% (HPLC)

Nkọwa dị mkpirikpi:

5- (Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dion.

Ọnọdụ: 15568-85-1

Dị ọcha:> 97.0% (HPLC)

Ọdịdị: Yellow Powder

Ọkara nke Lenvatinib Mesylate CAS 857890-39-2

Kpọtụrụ: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Nkọwa:

Ruifu Chemical Supply Lenvatinib Mesylate Intermediates nwere ịdị ọcha dị elu
Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
Desquinolinyl Lenvatinib;1- (2-Chloro-4-Hydroxyphenyl) -3-Cyclopropylurea CAS 796848-79-8
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5- (Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dion CAS 15568-85-1
4-Amino-3-Chlorophenol CAS 17609-80-2
4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4

Njirimara kemịkalụ:

Aha Chemical	5- (Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dion.
Ụdị okwu	5- (Methoxymethylene) Acid Meldrum;Cabozantinib adịghị ọcha 56;Lenvatinib adịghị ọcha 79
Nọmba CAS	15568-85-1
Nọmba CAT	RF-PI1967
Ọnọdụ Ahịa	N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi	C8H10O5
Ibu molekụla	186.16
Ebe Na-agbaze	132.0 ~ 134.0 ℃
Njupụta	1.297±0.06 g/cm3
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Ntụ ntụ odo
1 H NMR Spectrum	Nkwekọrịta na Ọdịdị
Ụzọ ịdị ọcha / nyocha	> 97.0% (HPLC)
Mgbakọta adịghị ọcha	<3.00%
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	Ndị etiti Lenvatinib Mesylate (CAS: 857890-39-2)

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri

Uru:

Ajụjụ:

Ngwa:

5- (Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dione (CAS: 15568-85-1) bụ etiti nke Lenvatinib Mesylate (CAS: 857890-39-2).Lenvatinib bụ ọgwụ cancer thyroid nke Eisai Corporation nke Japan mepụtara (koodu: E7080), bụ nke onye na-emechi ọnụ nke tyrosine kinase (RTK) nke na-emechi ọnụ ma nwee ike igbochi ọrụ kinase nke vascular endothelial growth factor (VEGF) ndị na-anabata VEGFR1. FLT1), VEGFR2 (KDR), na VEGFR3 (FLT4).Lenvatinib nwekwara ike igbochi itinye aka nke RTK ndị ọzọ na angiogenesis pathological, uto tumor, na ọganihu cancer ma e wezụga maka ọrụ cellular ha na-emekarị gụnyere fibroblast growth factor (FGF) ndị na-anabata FGFR1, 2, 3, na 4;ihe nnabata ihe uto nke platelet (PDGFR [alpha]), KIT, na RET.[Ngosipụta]: Lenvatinib dị mma maka ọgwụgwọ ndị ọrịa nke ọrịa cancer thyroid nke nlọghachi azụ mpaghara ma ọ bụ ụdị metastasis, ụdị ọganihu na redioactive iodine-refractory dị iche iche.Na February 13, 2015, US FDA kwadoro ọgwụ anticancer Lenvatinib maka ọgwụgwọ ọrịa cancer thyroid.Lenvatinib bụ onye na-egbochi enzyme multi-ezubere iche, na-enwe ike igbochi VEGFR2 na VEGFR3 (vaskụla endothelial growth factor receptor).Aha ahia nke Lenvatinib bụ Lenvima.Na May 20, 2015, Ụlọ Ọrụ Na-ahụ Maka Ọgwụ na Europe (EMA) kwadoro Lenvatinib maka ọgwụgwọ nke mkparị, nke dị na mpaghara ma ọ bụ metastatic dị iche iche (papillary, follicular, Hurthle ụdị) ọrịa cancer thyroid (DTC).N'ime ule ahụ, oge ndụ nke etiti maka ndị ọrịa nwere redioactive iodine refractory DTC nke a na-emeso Lenvatinib bụ ọnwa 18 ebe uru maka ndị ọrịa na-ewere placebo bụ nanị ọnwa 3.