Letrozole CAS 112809-51-5 API Factory Aromatase Inhibitor II Ogo dị elu
Nye ya na ịdị ọcha dị elu yana ịdị mma kwụsie ike
Aha Chemical: Letrozole
Nọmba: 112809-51-5
Ihe mgbochi Aromatase II
API Ogo dị elu, mmepụta azụmahịa
| Aha Chemical | Letrozole |
| Ụdị okwu | CGS-20267;Femara |
| Nọmba CAS | 112809-51-5 |
| Nọmba CAT | RF-API86 |
| Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms |
| Usoro ihe omimi | C17H11N5 |
| Ibu molekụla | 285.3 |
| Ebe Na-agbaze | 181.0 ruo 183.0 ℃ |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ntụ ntụ kristal na-acha ọcha ruo na-agbanyụọ |
| Solubility | Soluble n'efu na Dichloromethane, Soluble obere n'ime Ethanol yana nke na-adịghị edozi ya na mmiri. |
| njirimara IR | Spectrum nke sample dabara na nke ọkọlọtọ ntụaka |
| njirimara HPLC | Oge njide nke nlele ule dabara na nke ọkọlọtọ ntụaka |
| Ọdịnaya mmiri (nke KF) | ≤0.30% |
| Ihe fọdụrụ na mgbanye | ≤0.10% |
| Ihe ndị emetụtara | |
| Ihe ndị emetụtara A | ≤0.30% |
| Ihe ndị emetụtara B | ≤0.20% |
| Ọdịghị ọcha ọ bụla akọwapụtaghị | ≤0.10% |
| Mgbakọta adịghị ọcha akọwapụtaghị | ≤0.30% |
| Mgbakọta adịghị ọcha | ≤0.50% |
| Ihe mgbaze fọdụrụnụ | |
| Ethyl acetate | ≤0.50% |
| Methanol | ≤0.30% |
| Ethanol | ≤0.50% |
| DMF | ≤0.088% |
| Ọla dị arọ | ≤10ppm |
| Nyocha | 98.0% ~ 102.0% (na anhydrous ndabere) |
| Ndụ shelf | Ọnwa 24 |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | API, Aromatase Inhibitor II |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Letrozole (CAS 112809-51-5) bụ akụkụ nke ọgbọ ọhụrụ nke ndị na-egbochi aromatase na-ahọrọ nke ukwuu ma bụrụ ihe na-emepụta benzotriazole n'ụdị artificially.Letrozole na-egbochi aromatase iji belata ọkwa estrogen, si otú a na-egbochi estrogen site na-akpali uto tumor.Ọrụ ya na vivo siri ike ugboro 150-250 karịa nke ọgbọ mbụ aromatase inhibitor Amarante.Dị ka ọ na-ahọrọ nke ukwuu, ọ gaghị emetụta glucocorticoid, mineralocorticoid na thyroid ọrụ;ọbụlagodi na nnukwu doses, ọ gaghị enwe mmetụta ọ bụla na-egbochi ihe nzuzo corticosteroid adrenal, na-enye ya nchịkọta ọgwụgwọ dị elu.Letrozole enweghị ihe na-egbu egbu na-egbu egbu n'akụkụ usoro anụ ahụ ọ bụla na akụkụ ndị e lekwasịrị anya, enweghị mutagenicity na mmetụta carcinogenic, nwere mmetụta dị ntakịrị na-egbu egbu, na-anabata ya nke ọma, ma nwee mmetụta anticancer siri ike karịa ndị ọzọ aromatase inhibitors na ọgwụ antiestrogen.Letrozole dị mma maka ọrịa cancer ara na-emepe emepe postmenopausal ndị na-anabataghị ọgwụgwọ estrogen-suppressive na maka ọgwụgwọ ọrịa ara ara n'oge.A na-eji ya agwọ ndị ọrịa postmenopausal nwere ọrịa kansa ara dị elu ma na-eje ozi dị ka ọgwụgwọ nke abụọ iji soro ọgwụgwọ antiestrogen na-aga nke ọma.
