3,3′,5-Triiodo-L-Thyronine (Liothyronine; T3) CAS 6893-02-3 Ịdị Ọcha> Ụlọ ọrụ 95.0% (HPLC)

3,3',5-Triiodo-L-Thyronine (Liothyronine; T3) (CAS: 6893-02-3) bụ ike thyroid hormone receptors TRα na TRβ agonist na Kis nke 2.33 nM maka hTRα na hTRβ, n'otu n'otu.Liothyronine bụ homonụ nke thyroid na-emepụta.Emebere ya site na condensation nke L-3-Monoiodotyrosine na L-3.5-Diiodotyrosine.Ọdịnaya dị na anụ ahụ thyroid na ọbara dị obere karịa nke thyroxine, mana ọrụ ndụ ya dị okpukpu 5 ruo 10 karịa ya.T3 nwere mmetụta nke ịkwalite metabolism ihe onwunwe na ntọhapụ ume;ọ nwekwara ike ịkwalite uto na mmepe.Ndị okenye thyroid nkịtị na-ezobe 30 μg T3 kwa ụbọchị, 20% nke T3 na plasma sitere na nzuzo nzuzo nke thyroid, na 80% sitere na mgbanwe nke T4 plasma na mpụta.Levothyroxine ma ọ bụ L-Thyroxine bụ homonụ thyroid sịntetik nke dị na kemịkalụ ya na thyroxine (T4), bụ nke mkpụrụ ndụ follicular nke thyroid gland na-ezo na ya.A na-eji ya agwọ ụkọ hormone thyroid, na mgbe ụfọdụ iji gbochie nlọghachi nke ọrịa cancer thyroid.Dị ka ogbo ya zoro ezo, levothyroxine bụ ngwakọta chiral na ụdị L.A na-eji ọgwụ dextrothyroxine (D-thyroxine) metụtara ya n'oge gara aga dị ka ọgwụgwọ maka hypercholesterolemia (ọkwa cholesterol dị elu) mana ewepụrụ ya n'ihi mmetụta nke obi.Liothyroninea na-ejikarị eme ihe n'oge ịcha, nri nri, na / ma ọ bụ tupu asọmpi usoro ọzụzụ n'ihi ebumnuche zuru ụwa ọnụ nke usoro ndị a iji mebie abụba anụ ahụ, n'agbanyeghị na n'afọ ndị na-adịbeghị anya T3 enwetala ewu ewu dị ka onye na-arụ ọrụ bara uru n'oge bulking na oke inweta usoro. nke ọzụzụ (nke na-ejikọta ya na steroid) iji mee ka usoro nri dị mma na / ma ọ bụ mee ka abụba anụ ahụ dị ala n'oge oge oriri caloric dị elu.A na-ejikarị Liothyronine eme ihe na steroid n'ihi mmetụta ọ na-enwe na metabolism nke anụ ahụ n'ozuzu ya.Ọ dị ezigbo mkpa ịghọta na T3 enweghị oke na ihe na-eme ka metabolism ya dịkwuo elu - ọ ga-abawanye metabolism nke abụba, carbohydrates, na protein niile.Ya mere, gafere otu dose nke T3, enwere ohere dị ukwuu nke mfu ahụ site na ngbanwe nke protein.Site n'iji steroid na nri edoziri nke ọma, enwere ike igbochi mfu anụ ahụ a n'ihi T3 n'ihi ihe na-echekwa nitrogen na protein nke ndị steroid.Liothyronine na-ejikọta ya na ihe ndị na-efunahụ abụba ndị ọzọ iji mee ka mmetụta ya dịkwuo elu, ebe ọ na-arụ ọrụ synergistically na ndị ọzọ na-efunahụ abụba.