Lopinavir CAS 192725-17-0 API Ihe mgbochi mgbochi nje HIV COVID-19 dị ọcha

Lopinavir (ABT-378) bụ onye nwere ike nke ukwuu, onye na-egbochi peptidomimetic protease nke nje HIV-1, yana Kis nke 1.3 ruo 3.6 pM maka ụdị anụ ọhịa na nje nje HIV.Lopinavir na-eme ihe site na ijide nje HIV-1 tozuru okè si otú a na-egbochi nje ya.Lopinavir bụkwa ihe mgbochi SARS-CoV 3CLpro nwere IC50 nke 14.2 μM.Lopinavir bụ ọgwụ antiretroviral nke klas protease inhibitor.Mgbochi nke nje HIV-1 protease na-egbochi nkwụsị nke polyprotein precursor nke viral ma na-ebute ntọhapụ nke ndị na-eto eto, ndị na-adịghị efe efe.Akụkụ nke ọgwụgwọ ngwakọta iji gwọọ HIV/AIDS.Lopinavir, onye na-egbochi nje protease nke isii na klaasị "navir", ka ewepụtara ya na ritonavir, onye ọzọ na-egbochi nje nje HIV na-ere ahịa (Abbott, 1996);ewebata usoro izizi a dị ka Kaletra maka iji ya na nucleoside ma ọ bụ ndị na-abụghị nucleoside reverse transcriptase inhibitors maka ọgwụgwọ AIDS na ndị okenye na ụmụaka.Lopinavir bụ ngwakọta peptidomimetic nke nwere isi nhazi ya na nke ritonavir, bụ nke ndị otu ọnụ, ọkachasị valine emezigharịrị, webatara site na usoro njikọta peptide.Lopinavir bụ onye na-egbochi nje HIV-I protease nke na-egosipụta ikike dị elu megide mmụgharị na-eguzogide ritonavir.N'ime ụdị anụmanụ dị iche iche, ọmụmụ ọgwụ pharmacokinetic na otu lopinavirlritonavir gosipụtara na njirimara dị ala nke lopinavir dị mma nke ukwuu n'ihu ritonavir, n'ihe gbasara Cmax na oge ọrụ.