Potassium Losartan CAS 124750-99-8 API Ụlọ ọrụ na-eme ka ọbara mgbali elu dị ọcha
Na-ebunye Potassium Losartan na ihe jikọrọ ya na ịdị elu dị elu
Potassium Losartan CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
| Aha Chemical | Potassium Losartan |
| Ụdị okwu | DuP 753;Kọzara;2-Butyl-4-chloro-1-[2'- (1H-tetrazol-5-yl) -1,1'-biphenyl-4-yl] methyl] imidazole-5-methanol Potassium nnu. |
| Nọmba CAS | 124750-99-8 |
| Nọmba CAT | RF-API98 |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C22H22ClKN6O |
| Ibu molekụla | 461.01 |
| Ebe Na-agbaze | 263.0 ~ 265.0 ℃ |
| Solubility | Soluble n'efu na mmiri yana na methanol, Soluble dị ntakịrị na Acetonitrile. |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | White ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha kristal ntụ ntụ |
| njirimara A | Absorption infrared: Kwesịrị iyiri ọkọlọtọ ntụaka |
| njirimara B | Mmụba nke ultraviolet: Kwesịrị iyiri ọkọlọtọ ntụaka |
| Nwalee maka potassium | Kwesịrị ịdị mma |
| Ọdịnaya Mmiri (KF) | ≤0.50% |
| Ọla dị arọ | ≤10ppm |
| Ihe ndị emetụtara (HPLC) | |
| Ọdịghị ọcha nke Onye ọ bụla | ≤0.20% |
| Mgbakọta adịghị ọcha | ≤0.50% |
| Ihe mgbaze fọdụrụnụ (GC) | |
| Cyclohexane | ≤0.10% |
| Isopropyl mmanya | ≤0.20% |
| Usoro nyocha/nyocha | 98.5 ~ 101.0% (HPLC, gbakọọ na anhydrous, ihe mgbaze na-enweghị ihe ndabere) |
| N-Nitrosodiethylamine | ≤0.177pm (NDEA) |
| N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
| Nha urughuru | 90% Na-erughị 38 Microns |
| Ndụ shelf | Ọnwa 24 |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | API, Angiotensin II Nnabata Onye na-emegide ọbara mgbali elu |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Potassium Losartan bụ nke mbụ nwere ike na nhọrọ na-abụghị peptide angiotensin II antagonist nke ewebatara n'ahịa dị ka ọgwụ antihypertensive ọnụ otu ugboro kwa ụbọchị.Ntinye uche nke na-egbochi 50% nke njikọ nke angiotensin II (IC50) bụ 20 nM.Losartan (40 μM) na-emetụta ISC mana ọ na-egbochi mmetụta ANGII na ISC.Losartan na-ebelata nke ukwuu mgbasawanye cell Ang II na mkpụrụ ndụ cancer endometrial.Nchikota nke losartan na anti-miR-155 nwere mmetụta antiproliferative ka ukwuu ma e jiri ya tụnyere ọgwụ ọ bụla naanị.Ọ bụ metabolized iji mepụta 5-carboxylic acid metabolite (EXP3174) ma na-akọ na ọ na-ebelata ọbara mgbali.A na-enyocha ya ugbu a dị ka ọgwụgwọ enwere ike maka COVID-19 maka ike ya ibelata ma ọ bụ nwee ike belata akara ngosi nke COVID-19.
1. Maka ọgwụgwọ ọbara mgbali elu dị mkpa, enwere ike iji ya naanị ma ọ bụ yana ọgwụ ndị ọzọ na-egbochi hypertensive (dị ka diuretics).2. Maka ọgwụgwọ nke nkụda obi, enwere ike iji ya naanị ma ọ bụ jikọtara ya na ọgwụ cardiotonic ma ọ bụ diuretic Chemicalbook.3. Na-egbochi ọrịa strok na ndị ọrịa nwere ọbara mgbali elu na hypertrophy ventricular ekpe.4. A na-eji ya mee ihe iji belata ọganihu nke nephropathy na ndị ọrịa nwere ụdị ọrịa shuga 2 metụtara nephropathy na ọbara mgbali elu.
