Methyl 2-Oxoindoline-6-Carboxylate CAS 14192-26-8 Dị Ọcha>99.0% (HPLC) Nintedanib Esylate Factory Intermediate Factory
Shanghai Ruifu Chemical Co., Ltd. bụ onye na-emepụta ihe na onye na-ebubata Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) nwere àgwà dị elu, mmepụta azụmahịa.
Aha Chemical | Methyl 2-Oxoindoline-6-Carboxylate |
Ụdị okwu | 2-Oxoindoline-6-Carboxylic Acid Methyl Ester;Methyl Oxindole-6-Carboxylate |
Nọmba CAS | 14192-26-8 |
Nọmba CAT | RF-PI1524 |
Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
Usoro ihe omimi | C10H9NO3 |
Ibu molekụla | 191.19 |
Ebe Na-agbaze | 184.0 ~ 190.0 ℃ |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Agba odo na ntụ ntụ ntụ ntụ |
1 H NMR Spectrum | Nkwekọrịta na Ọdịdị |
Ụzọ ịdị ọcha / nyocha | > 99.0% (HPLC) |
Ọnwụ na ihicha | <1.00% |
Mgbakọta adịghị ọcha | <1.00% |
Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
Ojiji | Ọkara nke Nintedanib Esylate (CAS: 656247-18-6) |
Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) Ụzọ sịntetik
ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri.
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Methyl 2-Oxoindoline-6-Carboxylate (CAS: 14192-26-8) bụ ihe etiti eji akwado Nintedanib Esylate (CAS: 656247-18-6).Nintedanib Esylate bụ ihe na-eme ihe ike, ọnụ nke angiokinase atọ nke Boehringer Ingelheim mepụtara nke na-elekwasị anya ụzọ proangiogenic na pro-fibrotic ụzọ ndị na-anabata vaskụla endothelial growth factor receptor, fibroblast growth factor receptor na platelet enwetara uto nke ezinụlọ nnata, yana Src na Flt-3. kinases.A kwadoro Nintedanib Esylate maka ọgwụgwọ nke idiopathic pulmonary fibrosis (IPF), ọnọdụ nke ngụgụ na-eji nwayọọ nwayọọ na-afụ ụfụ ka oge na-aga, site na US FDA na October 2014 na EMA na January 2015. FDA nyere nintedanib esylate ngwa ngwa. , nlebanya mbụ, ngwaahịa nwa mgbei, na nhọpụta nhọpụta.EMA kwadoro ya na Nọvemba 2014 maka ọgwụgwọ ọrịa cancer akpa ume na-abụghị obere cell yana docetaxel mgbe usoro ọgwụgwọ mbụ gasịrị.
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