Methyl (S)-2-(Boc-amino) -3-[(S) -2-oxo-3-pyrrolidinyl] propanoate CAS 328086-60-8 PF-07321332 Boceprevir Intermediate

Nkọwa dị mkpirikpi:

Aha Chemical: Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate

Nọmba: 328086-60-8

Ọdịdị: White ka Gbanyụọ-Ọcha ntụ ntụ

Ọkara nke PF-07321332 Paxlovid (CAS 2628280-40-8) na Boceprevir (CAS 394730-60-0)

Ogo dị elu, mmepụta azụmahịa

Inquiry: alvin@ruifuchem.com

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Nkọwa:

Nbunye azụmaahịa PF-07321332 Ndị mmekọ Paxlovid nwere ogo dị elu.
L-tert-Leucine (H-Tle-OH) CAS 20859-02-3
Caronic Anhydride CAS 67911-21-1
(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride 565456-77-1
Methyl (S)-2-(Boc-amino) -3-[(S) -2-oxo-3-pyrrolidinyl] propanoate CAS 328086-60-8
6,6-Dimethyl-3-azabicyclo[3.1.0] hexane CAS 943516-54-9

Njirimara kemịkalụ:

Aha Chemical	Methyl (S)-2- (Boc-amino) -3-[(S) -2-oxo-3-pyrrolidinyl] propanoate
Ụdị okwu	Methyl (S) -2- ((tert-butoxycarbonyl) amino) -3- ((S) -2-oxopyrrolidin-3-yl) propanoate;(αS,3S) -α- [(tert-Butyloxycarbonyl) aMino] -2-oxo-3-pyrrolidinepropanoic acid Methyl Ester;(S) -Methyl 2- ((tert-butoxycarbonyl) amino) -3- ((S) -2-oxopyrrolidin-3-yl) propanoate.
Nọmba CAS	328086-60-8
Nọmba CAT	RF-PI317
Ọnọdụ Ahịa	Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms
Usoro ihe omimi	C13H22N2O5
Ibu molekụla	286.33
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Ọcha ka Gbanyụọ-Ọcha ntụ ntụ
njirimara A	IR: Yiri ihe ntụaka
njirimara B	Oge njide: Yiri ihe ntụaka
Ọnwụ na ihicha	≤1.0%
Ihe fọdụrụ na mgbanye	≤0.20%
Otu adịghị ọcha	≤0.50%
Mgbakọta adịghị ọcha	≤2.0%
Ọla dị arọ (Pb)	≤20ppm
Ịdị ọcha	≥98.0%
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	Ọkara nke PF-07321332 Paxlovid (CAS 2628280-40-8) na Boceprevir (CAS 394730-60-0)

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.

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Ajụjụ:

Ngwa:

Methyl (S) -2- (Boc-amino) -3- [(S) -2-oxo-3-pyrrolidinyl] propanoate (CAS 328086-60-8) bụ etiti nke PF-07321332 Paxlovid (CAS 2628280-40) -8) na Boceprevir (CAS 394730-60-0).PF-07321332, ihe bụ isi akụrụngwa nke Paxlovid (PF-07321332 na Ritonavir) bụ onye nyocha COVID-19 ọnụ na-achọ mgbochi nje, bụ onye na-egbochi ọnụ 3C-dị ka protease (3CLPRO) nwere mmetụta antiviral megide nje SARS-CoV-2. na COVID-19.Na Nọvemba 6th 2021, Pfizer kwupụtara na Paxlovid belatara ụlọ ọgwụ na ọnwụ nke ukwuu, dabere na nyocha nwa oge nke Oge 2/3 EPIC-HR (Nnyocha nke Inhibition Protease maka COVID-19 na Ndị ọrịa nwere nnukwu ihe ize ndụ) enweghị usoro, ọmụmụ kpuru okpukpu abụọ. nke ndị okenye na-abụghị ụlọ ọgwụ nwere COVID-19, ndị nọ n'ihe ize ndụ dị ukwuu nke ịga n'ihu na ọrịa siri ike.Boceprevir (EBP-520) bụ HCV protease inhibitor (Ki=14 nM) maka ọgwụgwọ nke nje virus ịba ọcha n'anya C.Boceprevir nwere pegylated interferon na ribavirin (PegIFN/RBV) mere ka mmụba dị n'ọkwa nzaghachi nje na-adịgide adịgide nke ndị ọrịa nwere genotype 1 HCV.Boceprevir na-emekọrịta ihe na ọgwụgwọ immunosuppressive (IT) site na igbochi cytochrome P450 3A enzyme.