N- (3-Chloro-4-Fluorophenyl) -7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Ịdị ọcha>99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Nkọwa dị mkpirikpi:

Aha Chemical: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

OZI: 162012-67-1

Dị ọcha:> 99.0% (HPLC)

Ọdịdị: Ìhè odo na-acha odo odo ntụ ntụ

Nke etiti Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Mkpado ngwaahịa

Nkọwa:

Ruifu Chemical Supply Intermediates of Afatinib
Afatirib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H) -otu CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl) -6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Njirimara kemịkalụ:

Aha Chemical	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
Ụdị okwu	N- (3-Chloro-4-Fluorophenyl) -7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl) (7-Fluoro-6-Nitroquinazolin-4-yl) amine;4- (3-Chloro-4-Fluoroanilino) -7-Fluoro-6-Nitroquinazoline;Afatirib Intermediate A
Nọmba CAS	162012-67-1
Nọmba CAT	RF-PI2026
Ọnọdụ Ahịa	N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi	C14H7ClF2N4O2
Ibu molekụla	336.68
Mmetụta	Mmetụta ikuku, Mmetụta okpomọkụ
Ebe Na-agbaze	242.0 ~ 244.0 ℃
Ebe esi nri	489 ℃
Njupụta	1.616
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Icha odo odo na ntụ ntụ odo
Ụzọ ịdị ọcha / nyocha	> 99.0% (HPLC)
Ọnwụ na ihicha	<0.50%
Ihe fọdụrụ na mgbanye	<0.20%
Ihe ndị emetụtara
Ọdịghị ọcha nke Onwe Onye	<0.50%
Mgbakọta adịghị ọcha	<1.00%
Ọla dị arọ	≤20ppm
Spectrum infrared	Dabara na Ọdịdị
Ọnụ ego nke Proton NMR Spectrum	Dabara na Ọdịdị
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	Nke etiti Afatinib Dimaleate (CAS: 850140-73-7)

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri

Uru:

Ajụjụ:

Ngwa:

N- (3-Chloro-4-Fluorophenyl) -7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) bụ etiti na njikọ nke Afatinib Dimaleate (CAS: 850140-73-7) .Afatinib Dimaleate bụ ụdị nnu nke Afatinib.Afatinib bụ ọgbọ nke abụọ, nke a na-enye ọnụ, onye na-egbochi ezinụlọ ErbB nke tyrosine kinases.Mechanism of ActionAfatinib na-agbadata akara ngosi ErbB site na ijikọ ọnụ na ngalaba kinase nke onye na-enweta uto uto epidermal (EGFR), onye na-anabata ihe na-eto eto nke mmadụ (HER) 2 na HER4, na-ebute mgbochi na-enweghị ike ịgbanwe nke tyrosine kinase autophosphorylation;ọ na-egbochikwa transphosphorylation nke HER3.Afatinib kwadoro dị ka monotherapy maka ọgwụgwọ EGFR tyrosine kinase inhibitor (TKI) - ndị okenye na-enweghị uche nwere ọganihu mpaghara ma ọ bụ DefinitionChEBI: Nnu nwoke enwetara site na ijikọta afatinib na molar abụọ dakọtara nke maleic acid.A na-eji ya maka ọgwụgwọ ahịrị mbụ nke ndị ọrịa nwere ọrịa kansa akwara metastatic na-abụghị obere cell.