N-Acetyl-L-Tyrosine CAS 537-55-3 (Ac-Tyr-OH; NALT) Ụlọ ọrụ nyocha 99.0 ~ 101.0
Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta ihe na onye na-ebubata N-Acetyl-L-Tyrosine (Ac-Tyr-OH; NALT) (CAS: 537-55-3) nwere oke mma.Ruifu Chemical na-enye usoro amino asịd na ihe mpụta.Ngwaahịa dị elu, ọnụahịa ezi uche dị na ya, ọrụ dị oke mma na ngwa ngwa mgbe ịre ahịa bụ nkwa nke Ruifu Chemical nye ndị ahịa.Anyị nwere ike ịnye COA, nnyefe zuru ụwa ọnụ, obere na nnukwu ọnụọgụ dị.Ọ bụrụ na ị nwere mmasị na N-Acetyl-L-Tyrosine,Please contact: alvin@ruifuchem.com
| Aha Chemical | N-Acetyl-L-Tyrosine |
| Ụdị okwu | Ac-Tyr-OH;Ac-L-Tyr-OH;N-Ac-L-Tyr;NALT;Ac-Tyrosine;Acetyltyrosine;N-Acetyltyrosine;Acetyl-Laevo-Tyrosine;LN-Acetyltyrosine;(2S) -2- (Acetylamino) -3- (4-Hydroxyphenyl) Propanoate;(S) -2-Acetamido-3- (4-Hydroxyphenyl) Acid propanoic;N-Acetyl-(S)-2-Amino-3- (4-Hydroxyphenyl)propionic Acid;(2S) -2- (Acetylamino) -3- (4-Hydroxyphenyl) propanoic acid. |
| Ọnọdụ Ahịa | N'ahịa, ikike nrụpụta 30 Tọn kwa afọ |
| Nọmba CAS | 537-55-3 |
| Usoro ihe omimi | C11H13NO4 |
| Ibu molekụla | 223.23 g/mol |
| Ebe Na-agbaze | 150.0 ka 154.0 ℃ |
| Njupụta | 1.304 |
| Mmiri Solubility | Soluble n'ime mmiri, ihe fọrọ nke nta ka ọ bụrụ nghọta |
| Okpomọkụ nchekwa. | Edechiri ya na nkụ, na-echekwa na okpomọkụ ụlọ |
| COA & MSDS | Dị |
| Nhazi | Amino Acids & Mwepụta |
| Ụdị | Ruifu Chemical |
| Koodu egwu | Xi - mgbakasị ahụ | F | 10 |
| Nkwupụta ihe egwu | 41-36/37/38 | TSCA | Ee |
| Nkwupụta nchekwa | 26-39-36 | Koodu HS | 2922491990 |
| WGK Germany | 3 |
| Ihe | Ụkpụrụ nyocha | Nsonaazụ |
| Ọdịdị | Crystal White ma ọ bụ ntụ ntụ kristal | Dabara |
| njirimara | Infrared absorption Spectrum | Dabara |
| Ntụgharị a kapịrị ọnụ [α]20/D | +46.5° ruo +49.0°(C=2 na H2O) | + 47.2 Celsius |
| Ọnọdụ Ngwọta (Nfefe) | ≥96.0% | 98.3% |
| Chloride (Cl) | ≤0.020% | <0.020% |
| Sulfate (SO4) | ≤0.020% | <0.020% |
| Ammonium (NH4) | ≤0.020% | <0.020% |
| Ígwè (Fe) | ≤30ppm | <30ppm |
| Ọla dị arọ (Pb) | ≤10ppm | <10ppm |
| Arsenic (As2O3) | ≤2.0pm | <2.0pm |
| Tyrosine | ≤1.00% | Dabara |
| Ọnwụ na ihicha | ≤0.50% | 0.25% |
| Ihe fọdụrụ na mgbanye (Sulfated) | ≤0.10% | 0.07% |
| Nyocha | 99.0 ruo 101.0% | 99.5% |
| Uru pH | 2.0 ruo 3.0 | 2.3 |
| Mmechi | Zutere ọkọlọtọ nke AJI97, USP35 | |
| Isi ojiji | Ihe mgbakwunye nri;Ihe mgbakwunye nri;Ndị na-ahụ maka ọgwụ | |
N-Acetyl-L-Tyrosine (Ac-Tyr-OH; NALT) (CAS: 537-55-3) Usoro ule AJI97
N-Acetyl-L-Tyrosine, mgbe akpọnwụwo, nwere ihe na-erughị 99.0 pasent na ọ bụghị karịa 101.0 pasent nke N-Acetyl-L-Tyrosine (C11H13NO4).
Nkọwa: kristal ọcha ma ọ bụ ntụ ntụ kristal, ụtọ acid siri ike
Na-agbaze kpamkpam na mmiri.
Solubility (H2O, g/100g): 17.5 (20 ℃), 72.4 (40 ℃), 158 (60 ℃)
Nchọpụta: Tụlee ụdị nnabata infrared nke ihe nlele ahụ na nke ọkọlọtọ site na usoro diski bromide potassium.
Ntụgharị a kapịrị ọnụ [α] 20/D: nlele akpọnwụwo, C=4, H2O
Ọnọdụ Ngwọta (Nfefe): 0.5g na 10ml nke H2O, spectrophotometer, 430nm, ọkpụrụkpụ sel 10mm.
Chloride (Cl): 0.7g, A-1, ntụgharị: 0.40ml nke 0.01mol/L HCl
Ammonium (NH4): B-1
Sulfate (SO4): 1.2g, (1), ntụgharị: 0.50ml nke 0.005mol/L H2SO4
Ígwè (Fe): 0.5g, ntụgharị: 1.5ml nke Ígwè Std.(0.01mg/ml)
Ọla dị arọ (Pb): 2.0g, (3), ntụgharị: 2.0ml nke Pb Std.(0.01mg/ml)
Arsenic (As2O3): 1.0g, (1), ntụgharị: 2.0ml nke As2O3 Std.
Ọnwụ na ihicha: na 105 ℃ maka awa 3
Ihe fọdụrụ na mgbanye (Sulfated): AJI Test 13
Nnwale: Ihe atụ a mịrị amị, 300mg, (1), 40ml H2O, (2), 0.1mol/L NaOH, 1ml=22.323mg C11H13NO4
Tyrosine: chromatography mmiri.Ọnọdụ ọrụ: Onye nchọpụta: fotometer absorption UV (214nm);Ogidi: ODS, 4.6mm x 150mm;Okpomọkụ kọlụm: Okpomọkụ ụlọ.Ọnụego ntinye: 1ml/min;Usoro mkpanaka: 0.04mol/L ngwọta nke monopotassium phosphate (pH 4.35): methanol (193: 3)
pH: 1.25g na 50ml nke H2O
Oke nchekwa akwadoro na ọnọdụ: arịa ndị siri ike echekwara na ụlọ okpomọkụ a na-achịkwa (afọ 2).
N-Acetyl-L-Tyrosine (Ac-Tyr-OH; NALT) (CAS: 537-55-3) Uzo ule USP35
Nkọwa
N-Acetyltyrosine nwere NLT 98.5% na NMT 101.0% nke C11H13NO4, dị ka N-Acetyl-L-Tyrosine, gbakọọ na ntọala akpọnwụwo.
Nchọpụta
A. AKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWỤKWASỊ"197K>
B. OPTICAL ROTATION, Ntụgharị a kapịrị ọnụ <781S>
Ngwọta nlele: 10 mg / ml
Usoro nnabata: NLT +46.0° na NMT +49.0°, kpebisiri ike na 20°
C. Uru RF nke isi ntụpọ nke ngwọta Sample na ule maka adịghị ọcha Organic dabara na nke ọkọlọtọ ọkọlọtọ 1.
ASSAY
Usoro
Ngwọta nlele: Gbarie ihe dịka 180 mg nke N-Acetyltyrosine, tụrụ, na 50 ml nke mmiri na-enweghị carbon dioxide.
Titrimetric usoro
(Lee Titrimetry <541>)
Ụdị: Direct titration
Titrant: 0.1 N sodium hydroxide VS
Nchọpụta njedebe: Potentiometric
Nhata: ML nke ọ bụla nke 0.1 N sodium hydroxide VS bụ 22.32 mg nke C11H13NO4.
IHE adịghị ọcha
Ihe adịghị ọcha
MKWAGHỊ ihe fọdụrụ <281>: NMT 0.1%
Chloride na sulfate, Chloride <221> NMT 200 ppm.Akụkụ 0.7-g na-egosi na ọ nweghị chloride karịa kwekọrọ na 0.40 ml nke 0.01 N hydrochloric acid.
Chloride na sulfate, sulfate <221> NMT 200 ppm.Akụkụ 1.2g na-egosi enweghị sulfate karịa dabara na 0.25 ml nke 0.020 N sulfuric acid.
IRON <241>: NMT 20ppm
Ọla dị arọ, Usoro I <231>: NMT 10ppm
Ihe adịghị ọcha
Usoro
Adsorbent: 0.25-mm oyi akwa nke chromatographic silica gel ngwakọta
Ihe ngwọta ọkọlọtọ 1: 8 mg/mL nke USP N-Acetyl-L-tyrosine RS na ngwakọta nke mmiri, glacial acetic acid, na mmanya (3:3:94)
Ọkọlọtọ ngwọta 1: Gwakọta ihe ngwọta ọkọlọtọ 1 na mmanya na-aba n'anya iji nweta ihe ngwọta nke nwere mkpokọta amara nke ihe dịka 0.4 mg/mL
Ngwọta ọkọlọtọ 2: 0.8 mg / mL nke USP L-Tyrosine RS gbazere na ngwakọta nke glacial acetic acid na mmiri (1: 1), wee tinye ya na mmanya.
Ngwọta nlele: Nyefee 0.8 g nke N-Acetyltyrosine na flask volumetric 10-mL, gbarie na 6 mL nke ngwakọta nke glacial acetic acid na mmiri (1: 1), ma gbanye mmanya na-aba n'anya.
Olu ngwa: 5µL
Sistemụ ihe mgbaze na-emepe emepe: ngwakọta nke amonia na 2-propanol (3:7)
Mgbasa reagent: igbari 0.2 g nke ninhydrin na 100 ml nke ngwakọta nke butanol na 2 N acetic acid (95: 5).
Sistemu kwesịrị ekwesị
Ihe achọrọ dabara adaba: chromatogram nke ngwọta dabara adaba sistemụ na-egosipụta ntụpọ abụọ kewapụrụ nke ọma.
Nyocha: Gaba n'ihu dị ka akwadoro maka Chromatography <621> Chromatography nke dị obere.Mgbe ikuku kpochara efere ahụ, megharịa usoro mmepe ahụ.Mgbe ikpochara ikuku nke ugboro abụọ, fesaa na Spray reagent, wee kpoo ọkụ n'etiti 100 ° na 105 ° maka ihe dịka 15 min.
Nkwenye nnabata: Ebe ọ bụla nke abụọ nke ihe ngwọta Sample adịghị ibu ma ọ bụ dị ike karịa ebe bụ isi nke Standard Solution1, ma e wezụga maka ntụpọ kwekọrọ na tyrosine, nke na-adịghị ibu ma ọ bụ dị ike karịa ebe bụ isi site na Standard Solution 2.
Ihe adịghị ọcha n'otu n'otu: NMT 0.5%
Oke nke tyrosine: NMT 1.0%
Nnwale akọwapụtara
Ịkpọ nkụ na-efu <731>: Kpochapụ ihe nlele na 105 ℃ maka awa 3: ọ na-efunahụ NMT 0.1% nke ịdị arọ ya.
NKWUO GBASARA YA
Nkwakọba na Nchekwa: Chekwaa n'ime akpa emechiri emechi nke ọma, ma chekwaa na okpomọkụ nke ụlọ a na-achịkwa.
Ụkpụrụ ntụaka USP <11>
USP N-Acetyl-L-tyrosine RS
USP L-Tyrosine RS
ngwugwu: Fluorinated Bottle, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Chekwaa n'ime akpa mechiri emechi n'ụlọ nkwakọba ihe dị jụụ, kpọrọ nkụ na ikuku ikuku na-anọghị n'ihe na-ekwekọghị ekwekọ.Chebe site na ìhè na mmiri mmiri.Wepụ ihe ndị na-eme ka oxidizing siri ike.
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Ọrụ & Ngwa nke N-Acetyl-L-Tyrosine (Ac-Tyr-OH; NALT) (CAS: 537-55-3) ntụ ntụ
1. N-Acetyl-L-Tyrosine bụ ihe acetyl sitere na amino acid, L-tyrosine.Ọ na-agbaze kpamkpam n'ime mmiri ma e jiri ya tụnyere L-tyrosine ma na-ejikarị ya dị ka ihe mgbakwunye nri parenteral.N-Acetyl-L-Tyrosine , ụdị tyrosine kwụsiri ike na nke soluble karịa, abanyela na ụfọdụ usoro amino acid parenteral azụmahịa dị ugbu a dị ka TrophAmine na Aminosyn-II.
2. N-Acetyl-L-Tyrosine na-etinye aka na mmepụta catecholamine.Enwere ike iji ya dị ka akụkụ mgbasa ozi omenala cell na azụmahịa biomanufacture nke protein recombinant ọgwụgwọ yana ọgwụ mgbochi monoclonal.
3. N-Acetyl-L-Tyrosine ọ bụ amino acid dị mkpa, nke bụ ụdị nri dị mkpa maka metabolism nke mmadụ na anụmanụ, uto na mmepe na-arụ ọrụ dị mkpa, enwere ike iji ya mee ihe n'ọtụtụ nri, ọgwụ ndị ọzọ.
4. N-Acetyl-L-Tyrosine na-arụ ọrụ dị mkpa na njikọ nke dopamine na hormones ndị ọzọ na ahụ gị.Ọ nwere ike ịkwalite ọkwa nke neurotransmitters dopamine, norepinephrine na epinephrine.Ọ na-enyere aka ịkwado ọkwa dị elu nke itinye uche na ọrụ ọgụgụ isi.Ọ nwere ike ịbawanye ebe nchekwa ọrụ na mmetụta nke ịdị mma.
5. N-Acetyl-L-Tyrosine gbanwere site na Tyrosine nkịtị n'ihi na ọ nwere mgbakwunye nke acetic acid.Nke a na-enye aka n'ezie ịbawanye bioavailability nke ogige ahụ nke mere na ọ ka mma itinye uche ya ozugbo n'ime ọbara.
6. N-Acetyl-L-Tyrosine bụ nnọọ bioavailable ụdị L-Tyrosine maka eke precursor ọgwụgwọ nke ala ọnọdụ N-Acetyl-L-Tyrosine nwere ike iji na ala doses karịa L-Tyrosine.L-Tyrosine nkịtị anaghị eguzosi ike na nke a na-esighi ike na mmiri, nke nwere ike ibute mbelata bioavailability.
7. N-Acetyl-L-Tyrosine na-eme ka solubility na nkwụsi ike na-eme ka ọ bụrụ ụdị amino acid L-Tyrosine nke na-adịghị adịkarị ngwa ngwa.
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