Palonosetron Hydrochloride CAS 135729-62-3 Ịdị Ọcha>99.0% (HPLC) (T) API Foto egosipụtara

Palonosetron Hydrochloride CAS 135729-62-3 Ịdị Ọcha>99.0% (HPLC) (T) Ụlọ ọrụ API

Nkọwa dị mkpirikpi:

Aha Chemical: Palonosetron Hydrochloride

OZI: 135729-62-3

Ọdịdị: White ma ọ bụ Gbanyụọ-White Crystalline Powder

Ọdị ọcha:> 99.0% (HPLC) (T)

Palonosetron Hydrochloride bụ ike dị ukwuu, nhọrọ na ọnụ na-arụ ọrụ 5-HT3 antagonist na-anabata ya na mgbochi na ọgwụgwọ nke ọgbụgbọ na vomiting na-akpata chemotherapy (CINV).Antiemetic.

Kpọtụrụ: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

Inquiry: alvin@ruifuchem.com

Zitere anyị email

Nkọwa ngwaahịa

Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Nkọwa:

Nbubata Azụmahịa Palonosetron Hydrochloride na ihe ndị metụtara ya:
(S) -1,2,3,4-Tetrahydro-1-Naphthoic Acid CAS: 85977-52-2
(R) -1,2,3,4-Tetrahedro-1-Naphthoic Acid CAS: 23357-47-3
(S) -3-Aminoquinuclidine Dihydrochloride CAS: 119904-90-4
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
1-Naphthoic Acid CAS: 86-55-5
Palonosetron Hydrochloride CAS: 135729-62-3 API

Njirimara kemịkalụ:

Aha Chemical	Palonosetron Hydrochloride
Ụdị okwu	Palonosetron HCl;(S, S) - Palonosetron Hydrochloride;RS-25259;RS25259 197;(S)-2-((S) -Quinuclidin-3-yl) -2,3,3a,4,5,6-Hexahydro-1H-Benzo[de] isoquinolin-1-otu Hydrochloride;(3aS)-2- (3S) -1-Azabicyclo[2.2.2] oct-3-yl-2,3,3a,4,5,6-Hexahydro-1H-benz[de] isoquinolin-1-otu Hydrochloride ;Aloxi;Onicit
Nọmba CAS	135729-62-3
Nọmba CAT	RF-API03
Ọnọdụ Ahịa	N'ọkwa, Mpụta Ihe ruru Tọn
Usoro ihe omimi	C19H24N2O·HCl
Ibu molekụla	332.87
Ọnọdụ Ịzere	Okpomọkụ nwere mmetụta
Ebe Na-agbaze	307 ℃ (Dec.)
Solubility na Mmiri	Na-agbaze kpamkpam n'ime mmiri
Solubility	Soluble dị ntakịrị na ethanol
Mbupu okpomọkụ	Okpomọkụ gburugburu
COA & MSDS	Dị
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Ntụ ntụ kristal na-acha ọcha ma ọ bụ gbanyụọ
Palonosetron Hydrochloride	> 99.0% (HPLC) (T)
Ntụgharị a kapịrị ọnụ [α]20/D	-98.0°～-104.0°
njirimara	Tinye BiI7K4 ， Mepụta ahịhịa odo odo oroma
njirimara	TLC dakọtara na ihe ntụnye aka
njirimara	IR kwekọrọ na ọkọlọtọ IR
njirimara	Nchọpụta dị ka chloride
Solubility	Na-agbaze n'ime mmiri kpamkpam, na-agbaze obere na methanol, soluble dị ntakịrị na ethanol, nke na-esighi ike na acetone.
Ịdị ọcha na agba nke ngwọta	Oke.Agba odo No. 2 Standard Agba Solution
pH Vaule	4.5 ~ 6.5 (10mg / ml)
Ihe ndị emetụtara
Ngwakọta emetụtara A (Mba)	<0.10%
Ngwakọta B (Ene-NO) emetụtara	<0.10%
Ngwakọta emetụtara C (S,R)	<0.10%
Ngwakọta emetụtara D (R,S)	<0.50%
Palonosetron Enantiomer	<0.10%
Ngwakọta emetụtara E (3-Ene)	<0.50%
Otu adịghị ọcha akọwapụtaghị	<0.10%
Ihe mgbaze fọdụrụnụ
Ethanol	<3000ppm
Tetrahydrofuran	<5000ppm
DMF	<880ppm
Hexane nkịtị	<290ppm
Methyl mmanya	<3000ppm
Isopropanol	<5000ppm
Methylbenzene	<890ppm
Mmiri	<0.30%
Ihe fọdụrụ na mgbanye	<0.20%
Ọnwụ na ihicha	<1.00%
Ọla dị arọ	<10ppm
Nlele ọkọlọtọ	United States Pharmacopoeia (USP);European Pharmacopoeia (EP)
Ojiji	Palonosetron Hydrochloride API;5-HT3 emegide;CINV

Ngwungwu & Nchekwa:

ngwugwu: Kalama, kaadiboodu Drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.

Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.

Uru:

Ajụjụ:

Ngwa:

Palonosetron Hydrochloride (CAS: 135729-62-3) bụ ọgwụ na-egbochi ọgbụgbọ na ọgbụgbọ, nke bụ ụdị ọhụrụ nke na-ahọrọ nke ukwuu, onye na-anabata ihe nnabata 5-HT3 dị elu nke nwere ike igbochi vomiting reflex center peripheral neurons presynaptic 5-HT.Obi ụtọ nnabata na-emetụta sistemu ụjọ nke etiti na 5-HT.Obi ụtọ na-anabata ihe na-akpali akpali site na ọrụ nke akwara afferent vagal mgbe mpaghara, na-egbochi njedebe akwara vagus na eriri afọ, na-egbochi akara na 5-HT.Mpaghara ndị na-anabata ihe nwere ike ibelata ọgbụgbọ na ọgbụgbọ.Central Clinical maka ọgwụgwọ nnukwu emetogenic chemotherapy butere ọgbụgbọ na ọgbụgbọ na-egbu oge.N'ihi mmetụta ọgwụgwọ dị elu ya, obere mmetụta dị n'akụkụ, ogologo oge ọkara ndụ (ihe dị ka awa 40), obere usoro ọgwụgwọ, na ihe ndị ọzọ, ọ dọtara mmasị dị ukwuu.

Na 1,2,3,4-Tetrahydro-1-Naphthoic Acid dị ka ihe mmalite, nkewa, amination, mbelata, cyclization, nnu nke palonosetron hydrochloride granisetron.Nnyocha ụlọ ọgwụ gosiri na enwere ike iji palonosetron mee ihe n'enweghị nsogbu na corticosteroids, analgesics, antiemetics, antispasmodics na anticholinergic ọgwụ dị ka ihe mmalite, nkewa, amination, mbelata, cyclization, nnu nke palonosetron hydrochloride granisetron.