Pregabalin CAS 148553-50-8 Dị Ọcha>99.0% (HPLC) API Antiepileptic

Pregabalin bụ ọgwụ antiepileptic nke ọgbọ nke abụọ (AED) mara aha ya nke Lyrica (Pfizer, Tadworth) na UK na USA, na-enwe usoro γ-amino butyric acid n'usoro ihe omimi ya, nke nwere mmetụta mgbochi, yana ọ bụ ya. Pfizer ụlọ ọrụ mepụtara nke ọma maka ọgwụgwọ mgbu neuropathic mpụta, ma ọ bụ ọgwụgwọ adjuvant nke ọdịdọ akụkụ.Pregabalin bụ Anticonvulsant na antiepileptic ọgwụ eji agwọ ọrịa Akwụkwụ na-adọ, neuropathic mgbu, fibromyalgia, na nsogbu nchekasị zuru oke.Ojiji ya maka Akwụkwụ na-adọ bụ ihe mgbakwunye mgbakwunye maka ọdịdọ akụkụ nke nwere ma ọ bụ na-enweghị mkpokọta nke abụọ na ndị okenye.Na December 2008, US Food and Drug Administration (FDA) kwadoro pregabalin (aha ahia "Lyrica") maka ọgwụgwọ nke ọrịa neuropathic peripheral neuropathic mgbu (DPN) na postherpetic neuralgia (PHN) nke bụ ma mgbu neuropathic na-emekarị.Pregabalin nwere ihe ngosi akwadoro ma ejiri ya mee ihe maka ọgwụgwọ nsogbu nchekasị zuru oke.Ọtụtụ randomized, kpuru ìsì abụọ, ebe a na-achịkwa ebebo chọpụtara na pregabalin bụ ọgwụgwọ dị irè maka ndị ọrịa nwere nsogbu nchekasị zuru oke na nsogbu nchekasị mmekọrịta ọha na eze.Usoro ọgwụgwọ Akwụkwụ na-agbakwụnye: 25 mg bd maka ụbọchị 7, a ga-abawanye site na 50 mg kwa ụbọchị 7;na-arụ ọrụ 300 mg kwa ụbọchị, kewara 2 ma ọ bụ 3 doses (max. 600 mg kwa ụbọchị, kewara 2 ma ọ bụ 3 doses).Nsogbu nchekasị zuru oke: 150 mg kwa ụbọchị, kewara n'ime 2 ma ọ bụ 3 doses, maka ụbọchị 7, na-abawanye site na 150 mg kwa ụbọchị 7 (max. 600 mg kwa ụbọchị, kewara 2 ma ọ bụ 3 doses).Ọ bụrụ na ịkwụsị pregabalin, a na-atụ aro ka ị tafe opekata mpe otu izu ka ịzenarị mwepu na mberede.Adọ aka na ntị Ndị ọrịa nwere ọnọdụ nwere ike ịkpalite encephalopathy.Ndị ọrịa nwere nkụchi obi siri ike.