PyBrOP CAS 132705-51-2 Ịdị Ọcha>99.0% (HPLC) Ụlọ ọrụ Njikọ Njikọ

Bromotripyrrolidinophosphonium Hexafluorophosphate (PyBrOP) (CAS: 132705-51-2) bụ reagent kwụsiri ike maka njikọta N-Methylamino acid na njikọ peptide.A na-eji ya maka njikọ nke depsipeptides.
PyBroP bụ peptide njikọta reagent nke ejirila na njikọ nke rostate tumor kpọmkwem peptide-peptoid ngwakọ prodrugs.Ngwakọta peptide na-emeghachi omume kwesịrị ekwesị maka α, α-dialkyl amino acids.
Ihe na-eme ka: njikọ nke amides isi, njikọ njikọ phosphonium na-ekpo ọkụ kpọmkwem, arylation kpọmkwem, nhazi pyrrolidide site na phosphonium nnu reagents.
PyBroP bụ nnu phosphonium eji na peptide njikọ kemịkalụ, nke yiri PyCloP.PyBroP na-egosi arụmọrụ dị elu na njikọta nke amino acid N-methylated na amino acid α, α na-agbanwe agbanwe, na-enwe ezigbo mkpụrụ, enweghị epimerisation na ọnụego mmeghachi omume ngwa ngwa.PyBroP bụ ihe siri ike kwụsiri ike nke enwere ike iji na usoro otu ite ma na-agbaze na ihe mgbaze a na-ejikarị maka kemịkalụ njikọ peptide.PyBroP bụ ihe mwepụta nke phosphonium njikọ reagent BOP mana nwere akụkụ pyrrolidine n'ọnọdụ dimethylamine nke BOP.Ebumnobi n'azụ imewe nke PyBroP bụ igbochi nguzobe nke ngwaahịa HMPA na-egbu egbu na carcinogenic nke sitere na BOP mepụtara, mana yana arụmọrụ yiri ya.
Enwere ike iji PyBroP mee ihe dị ka njikọ njikọ: Maka Suzuki-Miyaura cross-coupling of phenols na arylboronic acids iji mepụta biaryls na heterobiaryls.Iji rụọ ọrụ pyrimidine (nke sitere na 3,4-dihydropyrimidin-2 (1H) -ones (DHPMs) site na Kappe dehydrogenation) site na iji nucleophiles dị iche iche.Iji mepụta foramidines site na ijikọ na amines dị iche iche na N, N-diisopropylethylamine.Enwere ike iji ya dị ka reagent na-arụ ọrụ: Maka ịgbalite njikọ C-OH na heterocycles tautomerizable iji mepụta nnu phosphonium nke na-enyere aka njikọ Sonogashira nke heterocycles na alkynes dị iche iche.Maka otu-ite ịgbalite CO bond na phenols na n'ihu njikọ mmeghachi omume na phosphine oxide ma ọ bụ phosphite na-etolite CP bond.