(R)-(+) -2-Methyl-CBS-oxazaborolidine;(R)-Me-CBS Catalyst CAS 112022-83-0 Ngwa anya dị ọcha ≥98.0%

Onye nrụpụta;Ogo dị elu na ọnụ ahịa asọmpi

Ndị na-emepụta CBS
(S)-(-)-2-Methyl-CBS-oxazaborolidine;(S)-Me-CBS Catalyst (ihe dị ka 1mol/L na Toluene);Nọmba: 112022-81-8
(R)-(+) -2-Methyl-CBS-oxazaborolidine;(R) - Me-CBS Catalyst (ihe dị ka 1mol / L na Toluene);Nọmba ekwentị: 112022-83-0

CBS Catalyst
Ihe na-eme ka CBS ma ọ bụ Corey–Bakshi–Shibata catalyst bụ ihe mkpali asymmetric nke ewepụtara na proline.Ọ na-achọta ọtụtụ ojiji na mmeghachi omume organic dị ka mbelata CBS, mmeghachi omume Diels-Alder na (3+2) cycloadditions.Proline, ngwakọta chiral na-emekarị, dị ngwa ngwa yana ọnụ ala.Ọ na-enyefe stereocenter ya na ihe na-akpali akpali nke n'aka nke ya na-enwe ike ịkwọsa mmeghachi omume organic na-ahọrọ na otu n'ime ndị enantiomers abụọ nwere ike ime.Nhọrọ a bụ n'ihi nsogbu siri ike na ọnọdụ mgbanwe na-etolite maka otu enantiomer mana ọ bụghị maka nke ọzọ.

Ndị na-eme CBS maka mbelata asymmetric na synthesis asymmetric
Ejirila CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst na mbelata asymmetric nke ketones prochiral.Ngwa ndị ọzọ gụnyere njikọ enantioselective nke α-hydroxy acid, α-amino acid, C2-symmetrical ferrocenyl diols, na propargyl alcohols.

(R) (+) -2-Methyl-CBS-oxazaborolidine (ca. 1mol/L na Toluene) CAS: 112022-83-0 nwere ike iji mee ihe dị ka ihe na-akpali akpali na asymmetric borane mbelata nke perfluoroalkyl ketones.Ngwa ndị ọzọ gụnyere njikọ enantioselective nke α-hydroxy acid, α-amino acid, C2 symmetrical ferrocenyl diols, na propargyl alcohols.A na-ejikwa ya na mbelata desymmetry na-eduga na (S) -4-hydroxycyclohexenone.Ọ bara uru na mmepụta nke stereospecific motifs dị ka α-hydroxy acid, α-amino acid, symmetrical ferrocenyl diols na propargyl alcohols.

(R)-(+) -2-Methyl-CBS-oxazaborolidine (ca. 1mol/L na Toluene) CAS: 112022-83-0 bụ ihe na-eme ka ọkpụkpụ organoboron na-eme ihe na-emepụta ihe.Nke a na-akpali akpali, nke Itsuno na Elias James Corey mepụtara, na-emepụta site na kpo oku (R)-(+) - (diphenylhydroxymethyl) pyrrolidine tinyere trimethylboroxine ma ọ bụ methylboronic acid.Ọ bụ ngwá ọrụ magburu onwe ya maka njikọ nke alcohols na oke enantiomeric dị elu.N'ozuzu, a na-eji 2-10 mol% nke ihe na-eme ka a na-eme ihe yana borane-tetrahydrofuran (THF), borane-dimethylsulfide, borane-N, N-diethylaniline, ma ọ bụ diborane dị ka isi iyi.E jiriwo mbelata Enantioselective site na iji chiral oxazaborolidine catalysts na njikọ nke ọgwụ azụmahịa dị ka ezetimibe na aprepitant.