(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Ịdị Ọcha ≥99.7% (GC) Chiral Dị Ọcha ≥99.7% Panipenem na Darifenacin hydrobromide Intermediate
Onye nrụpụta;Ịdị ọcha dị elu na ọnụ ahịa asọmpi
Shanghai Ruifu Chemical Co., Ltd. Azụmahịa Chiral Compounds:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S) -3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
N'etiti Panipenem (CAS 87726-17-8) na Darifenacin hydrobromide (CAS 133099-07-7)
| Aha Chemical | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| Ụdị okwu | (R)-(-) -3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| Nọmba CAS | 104706-47-0 |
| Nọmba CAT | RF-CC102 |
| Ụzọ ịdị ọcha / nyocha | ≥98.0% (GC) |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C4H10ClNO |
| Ibu molekụla | 123.58 |
| Ebe Na-agbaze | 107.0 ~ 111.0 Celsius C |
| Solubility na Mmiri | Ihe fọrọ nke nta ka ọ bụrụ nghọta |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Gbanyụọ-White ruo Pale Brown Crystalline ntụ ntụ |
| Ụzọ ịdị ọcha / nyocha | ≥99.7% (GC) |
| Chiral ịdị ọcha | ≥99.7% ee |
| Ihe fọdụrụ na mgbanye | ≤0.50% |
| Ntụgharị pụrụ iche [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| Ọdịghị ọcha nke Onye ọ bụla | ≤0.20% |
| Mgbakọta adịghị ọcha | ≤0.30% |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | Ndị n'etiti ọgwụ;Ngwakọta Chiral |
Usoro nyocha
Ngwa: Ngwa GC (Shimadzu GC-2010)
Ogidi: DB-17 Agilent 30mX0.53mmX1.0μm
Okpomọkụ mbụ nke oven: 80 ℃
Oge mbu 2.0min
Ọnụ 15 ℃/min
Igwe ọkụ ọkụ ikpeazụ: 250 ℃
Oge ikpeazụ 20min
Nitrogen na-ebu gas
Usoro na-aga mgbe niile
Na-eru 5.0ml/min
Oke nkewa 10:1
Injector okpomọkụ: 250 ℃
Ọnọdụ okpomọkụ: 300 ℃
Olu ogwu ogbugba 1.0μL
Akpachara anya ka a ga-eme tupu nyocha:
1. Ọnọdụ kọlụm na 240 ℃ maka opekempe 30minutes.
2. Sachaa sirinji ma hichaa liner injector nke ọma iji wepụ ihe mmetọ nke nyocha mbụ.
3. Na-asa, kpoo ma jupụta diluent na vial ịsacha sirinji.
Nkwadebe mmiri ara ehi:
Kwadebe 2% w/v sodium hydroxide ngwọta n'ime mmiri.
Nkwadebe ọkọlọtọ:
Tụru ihe dịka 100mg nke (R) -3-hydroxyprolidine hydrochloride ọkọlọtọ n'ime vial, tinye 1mL nke mgbaze wee gbazee.
Nkwadebe nwale:
Were ihe dị ka 100mg nke nlele ule n'ime vial, tinye 1 ml nke ihe na-esi ísì ụtọ ma gbazee.Kwadebe na oyiri.
Usoro:
Tinye oghere (diluent), nkwadebe ọkọlọtọ na nkwadebe ule site na iji ọnọdụ GC dị elu.Eleghara ọnụ ọgụgụ ndị ahụ anya n'ihi oghere.Oge njide kacha elu n'ihi (R) -3-hydroxyprolidine bụ ihe dịka 5.0min.
Mara:
Kwuo nsonaazụ dịka nkezi
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Shanghai Ruifu Chemical Co., Ltd. bụ onye na-emepụta ihe na onye na-ebubata (R) - (-) 3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) nwere àgwà dị elu, nke a na-ejikarị eme ihe na njikọ organic, njikọ nke intermediates ọgwụ. yana njikọ Ingredient Pharmaceutical (API) na-arụ ọrụ.
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) bụ ihe etiti na-emekarị na njikọ nke Panipenem (CAS 87726-17-8) na Darifenacin hydrobromide (CAS 133099-07-7).
(R)-(-) 3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) bụ chiral hydroxy ewepụtara nke pyrrlodine eji na nkwadebe nke chiral niologically arụ ọrụ ogige dị ka muscarinic receptor antagonists na antimicrobial agents.
Ụzọ nke Synthesis nke (R) -3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile ka ejiri trimethyl chlorosilane mee ihe na dichloromethane ihe mgbaze iji nweta (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine wee mee hydrogenated na Pd / C catalyst.N'ikpeazụ, ngwaahịa (R) -3-hydroxypyrrolidine hydrochloride nwetara site na ọgwụgwọ hydrochloric acid gbadoro anya ma wepụrụ otu nchebe trimethylsilyl.
