(R) -Lansoprazole Dexlansoprazole CAS 138530-94-6 Assay 98.0 ~ 102.0% (HPLC) Ụlọ ọrụ
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(R) -Lansoprazole Dexlansoprazole CAS 138530-94-6
Aha Chemical | (R) - Lansoprazole |
Ụdị okwu | R-(+) -Lansoprazole;Dexlansoprazole;2-[(R)-[3-Methyl-4- (2,2,2-trifluoroethoxy) -2-pyridinyl] methyl] sulfinyl] -1H-benzimidazole;T 168390;TAK 390;Lansoprazole adịghị ọcha 14;Ihe ndị metụtara Dexlansoprazole 2;(R) -2-[[3-Methyl-4- (2,2,2-trifluoroethoxy) -2-pyridyl] methyl] sulfinyl] -1H-Benzimidazole; |
Nọmba CAS | 138530-94-6 |
Nọmba CAT | RF-PI1916 |
Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
Usoro ihe omimi | C16H14F3N3O2S |
Ibu molekụla | 369.36 |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Ntụ ntụ kristal na-acha ọcha ruo na-agbanyụọ |
Solubility | Soluble na Dimethylformamide, ọ fọrọ nke nta ka ọ bụrụ ihe a na-apụghị ịsacha na mmiri |
Ịdị ọcha & Agba nke Ngwọta | Na-emezu ihe achọrọ |
njirimara IR | Ụdị nnabata infrared kwesịrị ikwekọ na ihe ntụnyere aka |
njirimara HPLC | Oge njide nke isi kacha elu kwesịrị ikwekọ na nke ntụnyere aka |
Ntụgharị akọwapụtara | +142.0°~+149.0° |
Ebe Na-agbaze | ~ 140.0 ℃ |
Ọdịnaya Mmiri (KF) | <1.00% |
Ihe fọdụrụ na mgbanye | <0.10% |
Ihe adịghị ọcha emetụtara | (HPLC) |
Nitrogen Oxide | <0.10% |
Sulfone | <0.40% |
Sulfide | <0.20% |
Ọdịghị ọcha ọ bụla ọzọ | <0.10% |
Mgbakọta adịghị ọcha | <0.60% |
Ọcha anya (HPLC) | > 99.5% |
Nyocha | 98.0 ~ 102.0% (HPLC,% w / w, na anhydrous ndabere, ihe mgbaze-free) |
Ọla dị arọ | <10ppm |
Ihe mgbaze fọdụrụnụ | |
Toluene | <890ppm |
n-Heptane | <5000ppm |
Endotoxin nke nje bacteria | <2.5EU/mg |
Nlele ọkọlọtọ | Ụkpụrụ USP;Ndị China Pharmacopoeia |
Ojiji | API;Onye na-egbochi mgbapụta Proton na-arụ ọrụ ọnụ |
ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri
(R) -Lansoprazole (CAS: 138530-94-6) bụ R enantiomer nke Lansoprazole, Lansoprazole (AG 1749) bụ onye na-eme ihe na-eme ka proton mgbapụta ọnụ na-egbochi afọ imepụta acid.Dexlansoprazole maka Lansoprazole dextroisomer, bụ ụdị mgbochi peptic ọnyá afọ ọgwụ maka nnọchi benzimidazole usoro, na molekụla Ọdịdị n'ime mmewere fluorine, nke abụọ proton mgbapụta inhibitors omeprazole mgbe.Dexlansoprazole nwere mmetụta nke igbochi secretion nke gastric acid, mmetụta ahụ dị mma karịa nke ọgwụ ndị ọzọ (Omeprazole, Pantoprazole, Rebela, Tetrazolium) nwere ike igbochi ọnya ọnya.Ọ dị elu karịa famotidine ma ọ bụ Omeprazole maka mmebi nke mmanya na-aba n'anya na-akpata mucosa gastric na ọnya duodenal bụ nke kpatara hypersecretion acid.Na mgbakwunye, ngwaahịa ahụ nwere mmetụta mgbochi Helicobacter pylori dị ka nkwadebe bismuth, a na-ejikwa ya maka reflux esophagitis na ọrịa Zhuo AI.Takeda Pharmaceuticals nwetara nkwado nke dexlansoprazole, usoro ntọhapụ abụọ nke (R) -isomer nke lansoprazole proton pump inhibitor (PPI) ugbua na ahịa, site na FDA na Jenụwarị 2009. Dexlansoprazole bụ capsule ntọhapụ na-egbu oge maka otu ụbọchị, ọgwụgwọ ọnụ. nke nrekasi obi jikọtara ya na symptomatic na-abụghị erosive gastroesophageal reflux ọrịa (GERD), ọgwụgwọ erosive esophagitis (EE) na mmezi nke gwọọ EE.