Ramelteon (TAK-375) CAS 196597-26-9 Ịdị ọcha>99.5% (HPLC)

Ramelteon (CAS: 196597-26-9) bụ nke US Food and Drug Administration (FDA) kwadoro na mbụ na July 22, 2005, wee kwado ya site na Pharmaceuticals and Medical Devices Agency (PMDA) na Apr 16, 2010. E mepụtara ya na Ahịa dị ka Rozerem® site Takeda,enwere ike iji gwọọ ehighi ura na ihe isi ike ihi ụra, ma nwee mmetụta doro anya na ehighi ura na-adịghị ala ala na ehighị ụra nke dị mkpirikpi.Ngwaahịa a nwere ike họrọ nke ọma rụọ ọrụ ụdị 1 na ụdị 2 ndị na-anabata melatonin (MT1, MT2), mụbaa ụra nwayọ nwayọ (SWS) na ụra mmegharị anya ngwa ngwa (REW), wee si otú a belata ehighị ụra nke ọma.Ramelteamide bụ ọgwụ ọgwụgwọ ehighị ụra nke ọma na-eri ahụ nke na-anọghị n'okpuru njikwa pụrụ iche.Ngwaahịa a bụ melatonin agonist receptor.Ọ nwere mmekọrịta dị elu na melatonin MT1 na MT2 ndị na-anabata ya, ma nwee mmetụta agonist kpọmkwem zuru oke na ndị na-anabata MT1 na MT2, mana ọ naghị emekọrịta ihe na onye na-anabata MT3.Na mgbakwunye, ọ naghị ejikọta ndị na-anabata neurotransmitter dị ka ogige ndị na-anabata GABA, ọ dịghịkwa egbochi ọrụ nke ọtụtụ enzymes n'ime ebe ụfọdụ.Ya mere, ọ nwere ike zere ndọpụ uche metụtara ọgwụ GABA (nke nwere ike ịkpata ihe mberede ụgbọ ala, ọdịda na mgbaji).wdg) na ọgwụ riri ahụ na ịdabere.Rozerem® dị ka mbadamba ihe mkpuchi ihe nkiri maka ojiji ọnụ, nwere 8 mg nke Ramelteon efu.Usoro okenye akwadoro bụ 8 mg were n'ime nkeji 30 nke ịlakpu ụra.