Ramelteon Intermediate 12 CAS 1053239-39-6 Ịdị ọcha>98.0% (HPLC)

2- (2,6,7,8-Tetrahydro-1H-Indeno [5,4-b]furan-8-yl)ethanamine Hydrochloride (CAS: 1053239-39-6) bụ etiti nke Ramelteon (CAS: 196597- 26-9).N'adịghị ka ọtụtụ ọgwụgwọ nke ehighị ụra nke ọma na-elekwasị anya na GABA (g-aminobutyric acid), Ramelteon bụ agonist nke melatonin receptor.Karịsịa, ọ nwere nhọrọ dị elu maka ụdị subtypes MT1 na MT2, bụ ndị etinyere aka na mmezi nke usoro okirikiri circadian, n'elu onye na-anabata MT3 na-ahụ maka ọrụ melatonin ndị ọzọ.Enweghị mmekọrịta ya maka ọ bụghị naanị GABA receptor complex kamakwa neurotransmitter, dopaminerigic, opiate, na benzodiazepine receptors na-atụ aro profaịlụ nchekwa ka mma na-enweghị ike mmetọ nke ọgwụ hypnotic na-elekwasị anya ndị nnata a.Dị ka nke a, Ramelteon abụghị ọgwụ ahaziri.metabolites nke mbụ gụnyere hydroxylation na oxidation na ụdị carbonyl nwere metabolites nke abụọ sitere na glucuronidation.Ebe ọ bụ na CYP1A2 bụ isi isozyme na-etinye aka na metabolism imeju nke Ramelteon, e kwesịghị iji ya na ndị na-egbochi CYP1A2 siri ike, dị ka fluvoxamine.Njikọ aka na ketoconazole (onye na-emechi CYP3A4) ma ọ bụ fluconazole (onye na-emechi CYP2C9 nwere ike) butere mmụba dị ukwuu na AUC na Cmax, mana nnukwu metabolism na mgbanwe plasma dị ukwuu nke Ramelteon gbochiri mkpa mgbanwe dose.Ihe ntinye ngwugwu ahụ, agbanyeghị, na-adọ ndị ọrịa aka na ntị gbasara nkwado nke nwere ike CYP3A4 na CYP2C9 inhibitors.Dabere na nsonaazụ nke nnwale ụlọ ọgwụ, dose akwadoro nke Ramelteon bụ 8mg were n'ime nkeji 30 nke ịlakpu ụra.Na mgbakwunye na ịkpachara anya nke imekọ ihe ọnụ na ndị na-egbochi CYP, e kwesịghị iji ya na ndị ọrịa nwere nnukwu ọrịa imeju.Ihe omume ọjọọ, nke a na-ahụ na 5% nke ndị ọrịa na ọmụmụ ụlọ ọgwụ, bụ ụra nke ọma, dizziness, ọgbụgbọ, ike ọgwụgwụ, isi ọwụwa, na ehighi ura.