Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Foto egosipụtara dị elu

Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API Ogo dị elu

Nkọwa dị mkpirikpi:

Aha Chemical: Remdesivir (GS-5734)

OZI: 1809249-37-3

Ọdịdị: Ọcha ka Gbanyụọ-Ọcha Ntụ ntụ siri ike

Nyocha: 98.0% ~ 102.0%

Remdesivir maka ọgwụgwọ COVID-19

API Ogo dị elu, mmepụta azụmahịa

Inquiry: alvin@ruifuchem.com

Zitere anyị email

Nkọwa ngwaahịa

Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Nkọwa:

Onye nrụpụta Azụmahịa Remdesivir na ihe ndị metụtara ya nwere ogo dị elu
Remdesivir CAS 1809249-37-3
2-Ethyl-1-butanol CAS 97-95-0
Trimethylsilyl Cyanide CAS 7677-24-9
4-Nitrophenol CAS 100-02-7
2-Ethylbutyl ((S)-(perfluorophenoxy) (phenoxy) phosphoryl) -L-alaninate CAS 1911578-98-7
N-[(S)-(4-nitrophenoxy) phenoxyphosfinyl] -L-Alanine 2-ethylbutyl ester CAS 1354823-36-1
(S) -2-Ethylbutyl 2-Aminopropanoate Hydrochloride CAS 946511-97-3
Metabolite Remdesivir (GS-441524) CAS 1191237-69-0
Remdesivir N-2 Intermediate CAS 1191237-80-5
2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5
7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine CAS 937046-98-5
Pyrrolo[1,2-F][1,2,4]Triazin-4-Amine CAS 159326-68-8
4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine CAS 1770840-43-1

Njirimara kemịkalụ:

Aha Chemical	Remdesivir
Ụdị okwu	GS-5734;2-ethylbutyl ((S)-((2R,3S,4R,5R) -5- (4-aminopyrrolo [2,1-f][1,2,4]triazin-7-yl) -5-cyano -3,4-dihydroxytetrahydrofuran-2-yl) methoxy) (phenoxy) phosphoryl - L-alaninate.
Nọmba CAS	1809249-37-3
Nọmba CAT	RF-API96
Ọnọdụ Ahịa	Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms
Usoro ihe omimi	C27H35N6O8P
Ibu molekụla	602.58
Njupụta	1.47±0.1 g/cm3
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Ụtụ siri ike na-acha ọcha ruo na-acha ọcha
njirimara A	IR: Ụdị nnabata infrared nke ngwaahịa kwesịrị ịdị na nke ihe ntụnyere aka
njirimara B	Oge njide HPLC yiri ihe ntụaka
Ntụgharị akọwapụtara	-19.0° ~ -22.0°
Solubility	Solunle na methanol, Na-agbaze obere na Ethanol, Soluble obere na Acetonitrile, Na-adịghị Azịza nke ọma na Mmiri
Ihe ndị emetụtara
Ọdịghị ọcha nke Onye ọ bụla	≤0.10%
Mgbakọta adịghị ọcha	≤1.0%
RD-3.1	≤0.10%
RD-C	≤0.10%
RD-D	≤0.10%
RD-E	≤0.10%
RP-Isomer	≤0.10%
Nitrophenol	≤0.10%
Ihe mgbaze fọdụrụnụ
Methanol dichloride	≤6000ppm
Acetone	≤5000ppm
Isopropyl mmanya	≤5000ppm
Acetonitrile	≤410ppm
Dichloromethane	≤600ppm
Methyl tert Butyl Ether	≤5000ppm
Ethyl acetate	≤5000ppm
Tetrahydrofuran	≤720ppm
n-Heptane	≤5000ppm
Nyocha	98.0% ~ 102.0% (gbakọọ na nke a mịrị amị)
Ngụkọta ọnụ ọgụgụ ikuku
Aerobic nje bacteria	≤100cfu/g
Yist na ebu	≤10cfu/g
E. Igwe mmiri	Ihe ọjọọ
Endotoxin nke nje bacteria	≤1.0EU
Ọla dị arọ	≤20ppm
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	API, COVID-19

Ngwungwu & Nchekwa:

ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.

Uru:

Ajụjụ:

Ngwa:

Remdesivir (CAS 1809249-37-3), nke a na-ere n'okpuru akara aha Veklury, bụ ọgwụ mgbochi dị iche iche nke ụlọ ọrụ biopharmaceutical Gilead Sciences mepụtara.A na-enye ya site na injections n'ime vein.N'oge ọrịa COVID-19, akwadoro ma ọ bụ nye ikike remdesivir maka iji ihe mberede gwọọ COVID-19 n'ihe dị ka mba 50.Ntuziaka emelitere sitere na Healthtù Ahụ Ike wa na Nọvemba 2020 gụnyere ntụnye ọnọdụ megide iji Remdesivir maka ọgwụgwọ COVID-19.Emebere Remdesivir ka ọ gwọọ ịba ọcha n'anya C, ma emesịa nyocha ya maka ọrịa nje Ebola na nje Marburg tupu a mụọ ya dị ka ọgwụgwọ ọrịa na-efe efe maka COVID-19.Mmetụta kachasị emetụta ndị ọrụ afọ ofufo ahụike bụ mmụba ọbara nke enzymes imeju (ihe ịrịba ama nke nsogbu imeju).Mmetụta kachasị emetụta ndị nwere COVID-19 bụ ọgbụgbọ.Mmetụta nwere ike ịgụnye mbufụt imeju na mmeghachi omume metụtara infusion na ọgbụgbọ, ọbara mgbali elu, na ọsụsọ.Remdesivir bụ prodrug nke ezubere inye ohere nnyefe intracellular nke GS-441524 monophosphate na biotransformation na-esote n'ime GS-441524 triphosphate, ihe mgbochi analog nke ribonucleotide nke viral RNA polymerase.