Sitagliptin Phosphate Monohydrate CAS 654671-77-9 Dị Ọcha>99.0% (HPLC) API Ogo dị elu
Nnweta Sitagliptin Phosphate Monohydrate Njikọta:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R) -3-Amino-4- (2,4,5-Trifluoro-Phenyl) -Butyric Acid CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Phosphate Monohydrate Intermediate CAS 486460-21-3
| Aha Chemical | Sitagliptin Phosphate Monohydrate |
| Ụdị okwu | (R) -3-amino-1- (3- (trifluoromethyl) -5,6-dihydro-[1,2,4]triazolo [4,3-a] pyrazin-7 (8H) -yl)-4- (2,4,5-trifluorophenyl) butan-1-otu phosphate monohydrate |
| Nọmba CAS | 654671-77-9 |
| Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
| Usoro ihe omimi | C16H20F6N5O6P |
| Ibu molekụla | 523.3240802 |
| Ebe Na-agbaze | 202.0-204.0 ℃ |
| Mmiri Solubility | Soluble na Mmiri |
| Ntụgharị akọwapụtara | -18.0°~-23.0° (C=1, mmiri) |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ntụ ntụ kristal na-acha ọcha ruo na-agbanyụọ |
| Nchọpụta nke HPLC | Oge njide nke nlele na-akwado ụkpụrụ ntụaka |
| IR-Infrared Spectrum | Spectrum Absorption IR nke ihe nlele ahụ ga-adakọrịrị na nke ọkọlọtọ ọkọlọtọ |
| Phosphate | Na-akwado |
| Ụzọ ịdị ọcha / nyocha | > 99.0% (HPLC na ntọala a mịrị amị) |
| Ọdịnaya Mmiri (KF) | 3.3% ~ 4.4% |
| Ihe fọdụrụ na mgbanye | ≤0.20% |
| Sulfate | ≤0.02% |
| Chloride | ≤0.05% |
| Chiral adịghị ọcha | <0.50% |
| Ihe ndị emetụtara | |
| Otu adịghị ọcha | <0.50% |
| Mgbakọta adịghị ọcha | <1.0% |
| Ethyl acetate | <0.50% |
| Ọla dị arọ | <20ppm |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | Ndị na-ahụ maka ọgwụ |
ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri.
Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9), ọgwụ ọhụrụ maka ọgwụgwọ ụdị ọrịa shuga 2.N'August 2009, European Union kwadoro ọgwụ ahụ dị ka ọgwụ mbụ maka ọgwụgwọ ụdị ọrịa shuga 2.Sitagliptin Phosphate bụ onye mbụ FDA kwadoro dipeptidyl peptidase-IV inhibitor ka a ga-eji na-agwọ ụdị ọrịa shuga 2 ruo ogologo oge, n'okpuru aha ahia Januvia.Dipeptidylpeptidase Ⅳ (DPP-Ⅳ) ngwa ngwa na nke ọma na-eweda GLP-1, GLP-1, nke bụ ihe na-akpali akpali nke mmepụta insulin na nzuzo Ya mere, mgbochi nke DPP-IV nwere ike ịkwalite ọrụ nke GLP-1 endogenous, si otú ahụ na-abawanye ọbara. ọkwa insulin, si otú a na-ebelata ma na-edobe ọkwa glucose ọbara n'ime ndị ọrịa nwere ọrịa shuga.Ka ọ dị ugbu a, ọgwụ ekwenyela na DPP-IV inhibitor bụ ụdị ọhụrụ nke ọgwụ mgbochi ọrịa shuga, nsonaazụ ụlọ ọgwụ na-egosi na ọgwụ ndị ahụ nwere mmetụta hypoglycemic dị mma.N'ihi na GLP-1 na-arụ ọrụ dabere na glucose n'ịkwalite mmepụta insulin na nzuzo, mmeghachi omume na-adịghị mma dị ka hypoglycemia na oke ibu nke ojiji nke ọgwụ antidiabetic anaghị eme.
