Sitagliptin Triazole Hydrochloride CAS 762240-92-6 Dị Ọcha>99.0% (HPLC) Ụlọ ọrụ dị elu
Nnweta Sitagliptin Phosphate Monohydrate Njikọta:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
Boc-(R) -3-Amino-4- (2,4,5-Trifluoro-Phenyl) -Butyric Acid CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Phosphate Monohydrate Intermediate CAS 486460-21-3
Aha Chemical | 3- (Trifluoromethyl) -5,6,7,8-tetrahydro-[1,2,4]triazolo [4,3-a] pyrazine Hydrochloride. |
Ụdị okwu | Sitagliptin Triazole Hydrochloride;Sitagliptin Intermediate A |
Nọmba CAS | 762240-92-6 |
Nọmba CAT | RF-PI1193 |
Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
Usoro ihe omimi | C6H7F3N4·HCl |
Ibu molekụla | 228.60 |
Ebe Na-agbaze | 236.0 ~ 246.0 ℃ |
Solubility | Soluble na methanol |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Ntụ ntụ kristal na-acha ọcha ruo na-agbanyụọ |
Nchọpụta nke HPLC | Oge njide nke nlele na-akwado ụkpụrụ ntụaka |
njirimara nke IR | Na-akwado |
Ọnwụ na ihicha | <0.50% |
Ihe ndị emetụtara | |
Ọdịghị ọcha ọ bụla | <0.50% |
Mgbakọta adịghị ọcha | <1.00% |
Ọla dị arọ | <20ppm |
Ụzọ ịdị ọcha / nyocha | > 99.0% (HPLC) |
Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
Ojiji | Ọkara nke Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9) |
ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri.
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3- (Trifluoromethyl) -5,6,7,8-tetrahydro-[1,2,4]triazolo [4,3-a] pyrazine Hydrochloride (CAS: 762240-92-6) bụ etiti nke Sitagliptin Phosphate Monohydrate. CAS: 654671-77-9), nke bụ ọnụ-bioailable nhọrọ DPP4 inhibitor nke achọpụtara site na njikarịcha otu klas nke β-aminoacid-enwetara DPP4 inhibitors.Ọ na-ebelata ọrụ DPP4 n'ụzọ kwụsiri ike na-esochi otu ugboro kwa ụbọchị, na-echekwa ọkwa GIP na GLP1 na-ekesa mgbe nri na-esochi nri na ọmụmụ ihe siri ike na nke na-adịghị ala ala ma na-ebelata ọkwa glucose ọbara na-enweghị mmụba dị ukwuu na hypoglycemia.A na-eji Sitagliptin Phosphate (STG) na-agwọ DM ụdị 2 n'ihi na ọ na-eme ka njikwa glycemic dịkwuo elu site na ịbawanye ọkwa nke homonụ incretin na-arụ ọrụ, GLP-1 (peptide-1) na GIP (glucose-based insulinotropic peptide).FDA kwadoro STG na 2006.