Sorafenib CAS 284461-73-0 Ịdị Ọcha ≥99.0% (HPLC) API Ogo dị elu
Nbubata Azụmahịa Sorafenib Tosylate na ihe ndị metụtara ya:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4- (4-Aminophenoxy) -N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3- (Trifluoromethyl) phenyl Isocyanate CAS: 327-78-6
| Aha | Sorafenib |
| Ụdị okwu | Sorafenib Free Base |
| Nọmba CAS | 284461-73-0 |
| Nọmba CAT | RF-API04 |
| Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms |
| Usoro ihe omimi | C21H16ClF3N4O3 |
| Ibu molekụla | 464.82 |
| Njupụta | 1.454±0.06 g/cm3 |
| Solubility | Soluble na DMSO |
| Ọnọdụ mbupu | Okpomọkụ gburugburu |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ọcha ka Gbanyụọ-Ọcha ntụ ntụ |
| Ụzọ ịdị ọcha / nyocha | ≥99.0% (HPLC) |
| njirimara | H-NMR, MS |
| Ọnwụ na ihicha | ≤1.0% |
| Ihe fọdụrụ na mgbanye | ≤0.10% |
| Otu adịghị ọcha | ≤0.20% (HPLC) |
| Mgbakọta adịghị ọcha | ≤1.0% (HPLC) |
| Ọla dị arọ | ≤20ppm |
| Ngwọta doo anya | Dabaa na Standard |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | RCC & HCC |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ọkụ, mmiri mmiri na ụmụ ahụhụ.
Sorafenib Tosylate (CAS: 475207-59-1) bụ ụdị ọhụrụ ọgwụ antitumor nwere ọtụtụ ebumnuche, nke German Bayer Pharmaceuticals mepụtara, ma gosipụta ọrụ antitumor na-agbasawanye na nyocha anụmanụ nke izizi.Sorafenib dị na mbadamba 200-mg maka nchịkwa ọnụ ma ejiri ya na ọgwụgwọ RCC na HCC.Sorafenib Tosylate (CAS: 475207-59-1) nwere ike imetụta mkpụrụ ndụ tumo na arịa ọbara n'otu oge.Ọ nwere mmetụta antitumor okpukpu abụọ: ọ nwere ike igbochi ụzọ ntụgharị mkpụrụ ndụ nke RAF / MEK / ERK na-eme ka ọ ghara igbochi uto mkpụrụ ndụ tumo, ma na-egbochi VEGF na platelet derived growth factor (PDGF) iji gbochie nguzobe nke ọbara tumor ọhụrụ. arịa, yabụ na-egbochi uto cell tumor n'ụzọ na-edoghị anya.Sorafenib bụ onye na-egbochi Raf-1 na B-RAF yana ọtụtụ tyrosine kinases.
