Sorafenib Tosylate CAS 475207-59-1 Ịdị Ọcha ≥99.0% (HPLC) API Ụlọ ọrụ dị elu
Nbubata Azụmahịa Sorafenib Tosylate na ihe ndị metụtara ya:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4- (4-Aminophenoxy) -N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3- (Trifluoromethyl) phenyl Isocyanate CAS: 327-78-6
| Aha Chemical | Sorafenib Tosylate |
| Ụdị okwu | Nexavar;4-[4-[3-[4-Chloro-3- (Trifluoromethyl) phenyl] ureido] phenoxy] -N-Methylpicolinamide 4-Methylbenzenesulfonate;4-[4-[4-Chloro-3- (Trifluoromethyl) phenyl] carbamamido] phenoxy] -N-Methyl-2-Pyridinecarboxamide 4-Methylbenzenesulfonate;BAY 43-9006 Tosylate |
| Nọmba CAS | 475207-59-1 |
| Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms |
| Usoro ihe omimi | C21H16ClF3N4O3.C7H8O3S |
| Ibu molekụla | 637.03 |
| Ebe Na-agbaze | 225.0 ruo 230.0 ℃ |
| Mmetụta | Mmetụta ikuku, Mmetụta okpomọkụ |
| Solubility | Soluble na mmiri (<1 mg / ml) na 25 ℃, DMSO (127 mg / ml) na 25 ℃, na ethanol (<1 mg / ml) na 25 ℃ |
| Ọnọdụ mbupu | Ebe dị jụụ na nkụ (2 ~ 8 ℃), Chebe ọkụ |
| COA & MSDS | Dị |
| Ndụ shelf | Afọ 2 ma ọ bụrụ na echekwara ya nke ọma |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta | Nsonaazụ |
| Ọdịdị | Ọcha odo ma ọ bụ ntụ ntụ ọcha | Na-akwado |
| Ụzọ ịdị ọcha / nyocha | ≥99.0% (HPLC) | 99.8% |
| Ebe Na-agbaze | 225.0 ~ 230.0 ℃ | Na-akwado |
| Ọla dị arọ | ≤10ppm | <10ppm |
| Ọnwụ na ihicha | ≤0.50% | 0.12% |
| Ihe fọdụrụ na mgbanye | ≤0.20% | 0.10% |
| Ọdịghị ọcha ọ bụla | ≤0.50% | Na-akwado |
| Mgbakọta adịghị ọcha | ≤0.50% | Na-akwado |
| Ọnụ ego nke NMR Spectrum | Dabara na Ọdịdị | Na-akwado |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ | Na-akwado |
| Ojiji | Sorafenib Tosylate (CAS: 475207-59-1) na ọgwụgwọ nke RCC & HCC. | |
ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Chekwaa n'ime akpa mechiri emechi.Chekwaa n'ebe dị jụụ, kpọrọ nkụ (2 ~ 8 ℃) yana ụlọ nkwakọba ihe ikuku na-ekupụ nke ọma pụọ na ihe ndị na-ekwekọghị ekwekọ.Chebe site na ìhè na mmiri mmiri.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.
Koodu ihe ize ndụ 36/37/38 - na-akpasu anya, sistem iku ume na akpụkpọ ahụ.
Nkọwa Safety S28 - Mgbe emechara akpụkpọ ahụ, were ọtụtụ ncha-suds saa ozugbo.
S26 - N'ihe banyere kọntaktị na anya, kpochaa ozugbo na ọtụtụ mmiri ma chọọ ndụmọdụ ahụike.
Sorafenib Tosylate (CAS: 475207-59-1) bụ ụdị ọhụrụ ọgwụ antitumor nwere ọtụtụ ebumnuche, nke German Bayer Pharmaceuticals mepụtara, ma gosipụta ọrụ antitumor na-agbasawanye na nyocha anụmanụ nke izizi.Sorafenib dị na mbadamba 200-mg maka nchịkwa ọnụ ma ejiri ya na ọgwụgwọ RCC na HCC.Sorafenib Tosylate nwere ike imetụta mkpụrụ ndụ tumo na arịa ọbara tumor n'otu oge.Ọ nwere mmetụta antitumor okpukpu abụọ: ọ nwere ike igbochi ụzọ ntụgharị mkpụrụ ndụ nke RAF / MEK / ERK na-eme ka ọ ghara igbochi uto mkpụrụ ndụ tumo, ma na-egbochi VEGF na platelet derived growth factor (PDGF) iji gbochie nguzobe nke ọbara tumor ọhụrụ. arịa, yabụ na-egbochi uto cell tumor n'ụzọ na-edoghị anya.
Sorafenib Tosylate, aha ahia Nexavar, nke Bayer Pharmaceuticals mepụtara ya na Germany.Sorafenib Tosylate bụ ihe mgbochi multi-kinase nke enwere ike iji gwọọ ọrịa dịka ọrịa kansa.Na Disemba 2005, US FDA kwadoro ya ka ọ bụrụ ọgwụ izizi maka ọgwụgwọ ọrịa kansa akwara dị elu.N'August 2009, edepụtara ya na China site na nkwado nke nchịkwa nri na ọgwụ steeti.
Sorafenib Tosylate bụ tyrosine kinases (VEGFR na PDGFR) na RAF/MEK/ERK cascade inhibitors, na-eme n'otu oge na Raf-1,wtBRAF na V599EBRAF, na IC50 nke 6 nM, 22 nM na 38 nM, n'otu n'otu.
Sorafenib Tosylate nwere ike n'otu oge na-egbochi ụdị kinase dị iche iche nke dị na cell na elu cell, gụnyere RAF kinase, vascular endothelial growth factor receptor-2 (VEGFR-2), vascular endothelial growth factor receptor-3 (VEGFR-3), platelet. -ewepụtara ihe na-anabata ihe uto-β (PDGFR-β), KIT na FLT-3.Enwere ike ịhụ na sorafenib toluenesulfonate nwere mmetụta mgbochi tumor dual.N'otu aka ahụ, ọ nwere ike igbochi uto tumor ozugbo site na igbochi ụzọ akara RAF / MEK / ERK;N'aka nke ọzọ, ọ nwere ike igbochi VEGFR na PDGFR.Na igbochi guzobe akpụ neovascularization, indirectly inhibit uto nke akpụ mkpụrụ ndụ.Sorafenib Tosylate bụ ọgwụ kachasị dị irè maka ọgwụgwọ ọrịa cancer imeju na-aga n'ihu site na nchịkwa usoro, ọ ga-abụkwa na ọ ga-abụ ọgwụ ọhụrụ maka ọgwụgwọ ọrịa a.
Sorafenib Tosylate nchịkwa ọnụ otu ugboro kwa ụbọchị nke ụdị ntụgharị anụmanụ tumor mmadụ gosipụtara ọtụtụ ọrụ mgbochi tumor, gụnyere ọrịa cancer colon, carcinoma na-abụghị obere cell, ọrịa ara ara, melanoma, cancer pancreatic, leukemia na ọrịa cancer ovarian na mouse renal cell carcinoma nlereanya, RENCA nlereanya.
