Telmisartan CAS 144701-48-4 Ịdị ọcha> 99.5% (HPLC) Ụlọ ọrụ API
Ruifu Chemical Supply Telmisartan Intermediates nwere ịdị ọcha dị elu
Telmisartan CAS 144701-48-4
Methyl 2- (p-Tolyl) benzoate CAS 114772-34-8
2- (p-Tolyl) benzoic Acid CAS 7148-03-0
Telmisartan Benzimidazole Acid CAS 152628-03-0
Telmisartan Methyl Ester CAS 528560-93-2
Methyl 2-[4- (Bromomethyl) phenyl] benzoate CAS 114772-38-2
Methyl 4- (Butyrylamino) -3-Methyl-5-Nitrobenzoate CAS 152628-01-8
2-n-Propyl-4-Methyl-6- (1-Methylbenzimidazole-2-yl)benzimidazole CAS 152628-02-9
Aha Chemical | Telmisartan |
Ụdị okwu | 4'-[4-Methyl-6- (1-Methyl-1H-Benzimidazol-2-yl) -2-Propyl-1H-Benzimidazol-1-yl] methyl] biphenyl-2-Carboxylic Acid;4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-Benzimidazol]-1'-yl)methyl]-[1,1'-Biphenyl]-2-Carboxylic Acid |
Nọmba CAS | 144701-48-4 |
Ọnọdụ Ahịa | N'ọkwa, Mpụta Ihe ruru Tọn |
Usoro ihe omimi | C33H30N4O2 |
Ibu molekụla | 514.63 |
Ebe Na-agbaze | 261.0 ~ 263.0 ℃ |
Ụdị | Ruifu Chemical |
Ihe | Nkọwapụta |
Ọdịdị | Ntụ ntụ kristal na-acha ọcha ma ọ bụ gbanyụọ |
Isi | Njirimara |
Solubility | Na-agbaze obere n'ime Methylene chloride, ntakịrị Souble na methanol, nke a na-apụghị ịsacha na mmiri, na-agbaze na 1M Solution Hydroxide |
Nchọpụta IR | Kwesịrị dakọtara na RS Infrared Absorption |
HPLC njirimara | Oge njide nke isi kacha elu kwesịrị ikwekọ na RS |
Ụzọ ịdị ọcha / nyocha | > 99.5% (HPLC) |
Ọnwụ na ihicha | <1.00% |
Ihe fọdụrụ na mgbanye | <0.10% |
Ihe ndị emetụtara | |
Ihe jikọrọ Telmisartan A | <0.10% |
Telmisartan Amide | <0.10% |
Njikọ njikọ Telmisartan B | <0.10% |
Telmisartan Diacid | <0.10% |
Telmisartan Tert-Butyl Ester | <0.20% |
Telmisartan adịghị ọcha amaghi ama | <0.20% |
Ọdịghị ọcha na-akọwapụtaghị | <0.10% |
Mgbakọta adịghị ọcha | <1.00% |
Ihe mgbaze fọdụrụnụ | |
Methanol | <0.30% |
Ethanol | <0.50% |
Methylene dichloride | <0.06% |
n-Hexane | <0.029% |
Ethyl Ester nke acetic acid | <0.50% |
Toluene | <0.089% |
Acid acid | <0.50% |
Ọla dị arọ | <10ppm |
Arsenic (dị ka) | <1.00pm |
Ndu (Pb) | <1.00pm |
Cadmium (Cd) | <1.00pm |
Nha urughuru | D90 abụghị ihe karịrị 15μm |
Njupụta nnukwu (g/cc) | 0.11-0.20 |
Njupụta enwetara (g/cc) | 0.22-0.30 |
Ihe mgbochi pesticide fọdụrụnụ | Ihe ọjọọ |
Ngụkọta ọnụ ọgụgụ efere | <1000cfu/g |
Yist & ebu | <100cfu/g |
E. Coli | Ihe ọjọọ |
Salmonella | Ihe ọjọọ |
Nlele ọkọlọtọ | Ụkpụrụ ụlọ ọrụ;USP 41 ọkọlọtọ |
Ojiji | API |
ngwugwu: Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri
Telmisartan (CAS: 144701-48-4) bụ ihe nrụpụta benzimidazole na onye na-anabata angiotensin II na-abụghị peptide nwere ihe mgbochi hypertensive.Telmisartan na-ahọrọ nke ọma na-emegide angiotensin II na-ejikọta ya na AT1 subtype receptor, nke dị na akwara vaskụla dị nro na gland adrenal.Antagonism na-ebute vasodilation ma na-egbochi mmepụta aldosterone nke angiotensin II, nke na-eduga n'ịbelata sodium na mmiri yana mmụba nke nsị potassium na-eduga na mbelata ọbara mgbali elu na-esote.Telmisartan bụ ụdị ọgwụ mgbali elu ọhụrụ, nke a na-eji naanị ya ma ọ bụ yana yana klaasị antihypertensive ndị ọzọ maka ọgwụgwọ ọbara mgbali elu.Ụlọ ọrụ German na-emepụta ọgwụ bụ Boehringer Ingelheim mere Telmisartan na mbụ;ọ nwetara patent German EP502,314 na 1991, a kwadoro nke mbụ ịbanye n'ahịa America na November 1998, wee banye German, Philippines, Australian, Belgium, British, na ahịa ndị ọzọ.