Tranexamic Acid CAS 1197-18-8 Assay 99.0 ~ 101.0% (Titration)
Shanghai Ruifu Chemical Co., Ltd. bụ onye na-emepụta Tranexamic Acid (CAS: 1197-18-8) nwere oke mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Zụrụ Tranexamic Acid,Please contact: alvin@ruifuchem.com
| Aha Chemical | Tranexamic acid |
| Ụdị okwu | trans-4- (Aminomethyl) cyclohexanecarboxylic acid;trans-tranexamic acid;TAMCHA;AMCHA;HAKU;AMCA;t-AMCHA;trans-Amcha |
| Ọnọdụ Ahịa | Na ngwaahịa, Mmepụta Azụmahịa |
| Nọmba CAS | 1197-18-8 |
| Usoro ihe omimi | C8H15NO2 |
| Ibu molekụla | 157.21 g/mol |
| Ebe Na-agbaze | > 300 ℃ (ọkụ) |
| Nkwụsi ike | Hygroscopic |
| Mmiri Solubility | Soluble n'ime mmiri, ihe fọrọ nke nta ka ọ bụrụ nghọta |
| COA & MSDS | Dị |
| Nlereanya efu | Dị |
| Mmalite | Shanghai, China |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta | Nsonaazụ |
| Ọdịdị | White Crystalline ntụ ntụ | Na-akwado |
| Solubility | Soluble n'ime mmiri yana glacial acetic acid, ọ fọrọ nke nta ka ọ ghara ịgbaze na Ethanol na Acetone (96%) | Na-akwado |
| IR Spectrum | Na Concordance na Tranexamic Acid CRS | Na-akwado |
| pH | 7.0-8.0 | 7.32 |
| Ọnwụ na ihicha | <0.50% | 0.06% |
| Sulfate ntụ ntụ | <0.10% | 0.02% |
| Ọla dị arọ (Pb) | ≤10ppm | <10ppm |
| Chloride (Cl) | ≤140ppm | <140ppm |
| Arsenic (dị ka) | ≤2pm | <2pm |
| Nyocha | 99.0 ~ 101.0% (site na Titration) | 99.84% |
| Ihe ndị emetụtara | ||
| adịghị ọcha A | <0.10% | 0% |
| adịghị ọcha B | <0.20% | 0.0815% |
| adịghị ọcha C | <0.10% | 0.0089% |
| adịghị ọcha D | <0.10% | 0.0063% |
| Mgbakọta adịghị ọcha | <0.20% (Ewezuga A,B) | 0.015% |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
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Tranexamic acid
C8H15NO2 157.2
trans-4- (Aminomethyl) cyclohexanecarboxylic acid;
Cyclohexanecarboxylic acid, 4- (aminomethyl), trans [1197-18-8].
Nkọwa
Tranexamic acid nwere NLT 99.0% na NMT 101.0% nke C8H15NO2, gbakọọ na ntọala akpọnwụwo.
Nchọpụta
• Ntinye infrared <197K>
ASSAY
• Usoro
Ihe ngwọta nlele: 140 mg nke Tranexamic acid na 20 ml nke glacial acetic acid.
Titrimetric usoro
(Lee Titrimetry <541>.)
Ụdị: Direct titration
Titrant: 0.1 N perchloric acid VS
Nchọpụta njedebe: Potentiometric
Nyocha
Ihe atụ: Ngwọta nlele
Titrate na 0.1 N perchloric acid VS, na-ekpebi ebe njedebe nwere ike.Mepụta titration efu.
Otu ml nke 0.1 N perchloric acid bụ 15.72 mg nke C8H15NO2.
Usoro nnabata: 99.0% -101.0% na ntọala akpọnwụwo
IHE adịghị ọcha
Ihe adịghị ọcha
• Ihe fọdụrụ na mgbanye <281>: NMT 0.1%;A na-eji 1-g sample
• Ọla dị arọ, Usoro II <231>: NMT 10 ppm
• Chloride na sulfate, Chloride <221>: Akụkụ 0.51-g na-egosi na ọ dịghị chloride karịa kwekọrọ na 0.1 mL nke 0.020 N hydrochloric acid (0.014%).
Ihe adịghị ọcha
• Usoro
Usoro mkpanaaka: Igbari 11.0 g nke anhydrous monobasic sodium phosphate na mmiri 500 ml, tinye 5 ml nke triethylamine, sochiri 1.4 g nke sodium lauryl sulfate.Gbanwee na diluted phosphoric acid (10% w / w) ka a pH nke 2.5, na itughari na mmiri ka 600 ml.Gwakọta ihe ngwọta a na 400 ml nke methanol.
Ngwọta ndabara sistemu: 0.2 mg/mL nke USP Tranexamic Acid RS na 0.002 mg/mL nke USP Tranexamic Acid metụtara Compound C RS na mmiri
Ọkọlọtọ ngwọta: 50 μg/mL nke USP Tranexamic Acid RS n'ime mmiri
Ihe ngwọta nlele: 10 mg/mL nke Tranexamic Acid n'ime mmiri
Sistemụ chromatographic
(Lee Chromatography <621>, Kwesịrị ekwesị Sistemu.)
Ụdị: LC
Ihe nchọpụta: UV 220 nm
Ogidi: 4.6-mm × 25-cm;5-µm mbukota L1
Ọnụego mmiri: 1 ml / min
Nha igba ogwu: 20µL
Oge ịgba ọsọ: oge 3 tranexamic acid ugboro 3
Sistemu kwesịrị ekwesị
Ọmụma: Ngwọta dabara adaba sistemụ
Kwesịrị ekwesị chọrọ
Mkpebi: NLT 2.0 n'etiti Tranexamic Acid na 0.002 mg/mL nke tranexamic acid metụtara C
Nyocha
Ihe atụ: Ngwọta ọkọlọtọ na ngwọta nlele
Gbakọọ pasent nke adịghị ọcha onye ọ bụla na akụkụ Tranexamic Acid were:
Nsonaazụ = (rU/rS) × (CS/CU) × (0.1F)
rU = nzaghachi kacha elu maka adịghị ọcha ọ bụla site na ngwọta Sample
rS = nzaghachi kacha elu maka tranexamic acid sitere na ngwọta ọkọlọtọ
CS = ntinye uche nke USP Tranexamic Acid RS na ngwọta ọkọlọtọ (µg/mL)
CU = ntinye tranexamic acid n'ime ihe ngwọta nlele (mg/mL)
F = ihe nzaghachi nke ikwu (lee Tebụl adịghị ọcha 1)
Usoro nnabata
Ihe adịghị ọcha n'otu n'otu: Lee Tebụl adịghị ọcha 1.
Mkpokọta adịghị ọcha: NMT 0.2%
[Chebaraba ama-eleghara ọnụ ọgụgụ ọ bụla na-erughị 0.025% anya]
Tebụl adịghị ọcha 1
Aha Oge Njide Ndị ikwu Nkwekọrịta Nkwekọrịta Nkwekọrịta, NMT (%)
Ngwakọta metụtara tranexamic acid Aa 2.1 1 0.1
Ngwakọta metụtara tranexamic acid Bb 1.5 1.2 0.2
Ngwakọta metụtara tranexamic acid CC 1.1 0.005 0.1
Tranexamic acid 1.0 1.0 -
Ngwakọta metụtara tranexamic acid Dd 1.3 0.006 0.1
a trans, trans-4,4 ¢-(Iminodimethylene) di (cyclohexanecarboxylic) acid.
b cis-4- (Aminomethyl) cyclohexanecarboxylic acid.
c (RS) -4- (Aminomethyl) cyclohex-1-enecarbocylic acid.
d 4-Aminomethyl benzoic acid.
Nnwale akọwapụtara
• Mfu na ihicha <731>: 1.00 g akọrọ na 105 n'okpuru oghere maka awa 2.Ọ na-atụfu NMT 0.5% nke ibu ya.
NKWUO GBASARA YA
• Nkwakọ ngwaahịa na Nchekwa: Chekwaa n'ime akpa siri ike, ma chekwaa na okpomọkụ na-agaghị agafe 30.
• Ụkpụrụ ntụaka USP <11>
USP Tranexamic Acid RS Pịa ka ilele Ọdịdị
Ngwakọta jikọtara USP Tranexamic Acid C RS
(RS) -4- (Aminomethyl) cyclohex-1-enecarbocylic acid.
C8H13NO2 155
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Klas ihe egwu IGBO
Nsi LD50 na ụmụ oke, oke (mg/kg): 1500, 1200 iv (Melander)
Tranexamic acid (CAS: 1197-18-8) bụ ihe sintetịt sitere na amino acid lysine.Tranexamic acid (a na-erekarị ya n'ụdị mbadamba nkume Lysteda na n'ụdị IV dị ka Cyklokapron na US yana Transamin,Transcam na Asia, na Espercil). na South America) na-enyekarị iwu maka oke ọbara ọgbụgba.Tranexamic acid bụ antifibrinolytic nke na-asọmpi na-egbochi ịgbalite plasminogen na plasmin, molecule na-akpata mbibi fibrin.Fibrin bụ ntọala bụ isi maka ịmepụta mkpụkọ ọbara na hemostasis. Tranexamic acid nwere ihe dị ka ugboro 8 ọrụ antifibrinolytic nke analog ochie, ε-aminocaproic acid.Emere ya patent nke izizi na 1957 wee nweta nkwado US izizi ya na 1986. Tranexamic Acid Appliciton A na-eji ya dị ka ihe ịchọ mma na-acha ọcha A na-ejikarị ya eme ihe n'ụlọ ọgwụ na ngalaba ịwa ahụ, ọgwụ ime ime, urology, obstetrics na gynecology, wdg iji gwọọ ọrịa ọgbụgba ọbara dị iche iche Ọbara ọgbụgba na-adịghị mma n'oge ịwa ahụ, wdg. A na-ewere ya dị ka ọgwụ hemostatic, nke a na-ejikarị maka hemostasis mgbe nnukwu ịwa ahụ na mgbe ọmụmụ gasịrị.N'ezie, hemostasis nwere ike ịbụ ihe kacha nta mere na-agbakwunye ọtụtụ ihe ntacha eze na-atụ anya inwe mmetụta.
Acid tranexamic (CAS: 1197-18-8)
Ịwa ahụ obi
A na-ejikarị ya na ịwa ahụ obi, ma na-enwe ma na-enweghị mgbagha mkpụrụ obi.Ọ na-anọchi aprotinin.
Ọbara ọgbụgba nsọ
Ejiri ya dị ka ọgwụgwọ na-abụghị nke homonụ nke izizi nke ọbara ọgbụgba uterine na-adịghị arụ ọrụ, yana ọbara ọgbụgba dị arọ jikọtara ya na fibroids uterine.Nnyocha e mere n'oge na-adịbeghị anya gosiri na ndị ọrịa ejiri tranexamic acid agwọ ọrịa na-enwekarị ike ịmalite thrombosis na necrosis na fibroids ha, ma nwee ike ịkpata mgbu na ahụ ọkụ.
Mmetụta na-acha ọcha
Nnyocha ụlọọgwụ kemgbe ọtụtụ afọ egosila na tranexamic acid nwere ike imebi ntụpọ ahụ nke ọma na ngwa ngwa, nke na-enyere aka igosipụta ezigbo ọcha na akpụkpọ ahụ.Mmetụta iwepụ ntụpọ nke tranexamic acid dị ihe dị ka ugboro 50 karịa vitamin C, yana ugboro iri karịa AHA.Oke itinye uche nke ojiji bụ 2%-3%, na ihe ịchọ mma, ego ya dị gburugburu 0.5%
1. Ezi nkwụsi ike
E jiri ya tụnyere ihe ndị na-acha ọcha nke ọdịnala, tranexamic acid nwere nkwụsi ike dị elu, nguzogide acid na alkali, na ọnọdụ okpomọkụ anaghị emetụta ya ngwa ngwa;Enweghị nchebe ụgbọelu, enweghị mmebi usoro nnyefe, enweghị mkpali.
2. Usoro akpụkpọ ahụ dị mfe ịbanye
Ọ dabara adaba maka ntụpọ ọkụ, ịcha ọcha na ịhazi ụda akpụkpọ ahụ dum.Na mgbakwunye na ime ka ntụpọ ahụ dị ọkụ, tranexamic acid nwekwara ike imeziwanye nghọta nke ụcha akpụkpọ ahụ n'ozuzu ya na nkụchi nke oke akpụkpọ ahụ.
3. Ọ nwere ike ịchachapụ ntụpọ ojii, freckles odo, akara otutu, wdg
A na-ebute ntụpọ ojii site na mmebi UV na ịka nká na ihe ndị ọzọ.Clotting acid nwere ike igbochi ọrụ tyrosinase na melanocytes, belata mmepụta nke melanin site na basal oyi akwa nke epidermis, ma nwee mmetụta nke iwepụ ntụpọ uhie.
4. Nchekwa dị elu
Ihe kachasị elu na ihe ịchọ mma bụ 2% ~ 3%.
5. Mmetụta na-acha ọcha
Tranexamic acid dabara n'ụdị akpụkpọ anụ ọ bụla maka iwepụ pigmenti, na-acha ọcha akpụkpọ na ibelata ntụpọ, dị ka: pigmentation mgbe anwụ kpughee;Ebe gbara ọchịchịrị;Akpụkpọ anụ nwere mmetụta;Ihe otutu na mbufụt;Nlekọta mgbe ịwachara ahụ mgbe laser gasịrị, ọgwụgwọ ọkụ pulsed.
