trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Ịdị ọcha>98.0% (HPLC) Afatinib Dimaleate Intermediate

Nkọwa dị mkpirikpi:

trans-4-Dimethylaminocrotonic acid hydrochloride

Nọmba: 848133-35-7

Dị ọcha:> 98.0% (HPLC)

Ọdịdị: Ọcha ka ọ fọrọ nke nta ka ọ bụrụ ọcha ntụ ntụ

Nke etiti Afatinib Dimaleate (CAS: 850140-73-7)

Kpọtụrụ: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Zitere anyị email

Nkọwa ngwaahịa

Ngwaahịa ndị emetụtara

Mkpado ngwaahịa

Nkọwa:

Ruifu Chemical Supply Intermediates of Afatinib
Afatirib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H) -otu CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7-((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl) -6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Njirimara kemịkalụ:

Aha Chemical	trans-4-Dimethylaminocrotonic acid hydrochloride
Ụdị okwu	trans 4-Dimethylaminocrotonic acid HCl;(E) -4- (Dimethylamino) -2-Butenoic Acid Hydrochloride;(E) -4-Dimethylaminocrotonic Acid Hydrochloride;(2E) -4- (Dimethylamino) ma-2-Enoic Acid Hydrochloride;Afatinib int-2
Nọmba CAS	848133-35-7
Ọnọdụ Ahịa	N'ọkwa, Azụmahịa Azụmahịa
Usoro ihe omimi	C6H12ClNO2
Ibu molekụla	165.62
Mmetụta	Hygroscopic.Mmiri nwere mmetụta
Ebe Na-agbaze	160.0 ruo 164.0 ℃
Solubility	DMSO (obere), methanol (obere), mmiri (obere)
COA & MSDS	Dị
Mmalite	Shanghai, China
Ụdị	Ruifu Chemical

Nkọwapụta:

Ihe	Nkọwapụta
Ọdịdị	Ọcha ka ọ fọrọ nke nta ka ọ bụrụ ọcha ntụ ntụ
Ụzọ ịdị ọcha / nyocha	> 98.0% (HPLC)
Ụzọ ịdị ọcha / nyocha	> 98.0% (NMR)
Mmiri (KF)	<0.50%
Ihe fọdụrụ na mgbanye	<0.20%
Otu adịghị ọcha	<0.50%
Ọla dị arọ (dị ka Pb)	<20ppm
Spectrum infrared	Dabara na Ọdịdị
1 H NMR Spectrum	Ọnụ ego nke Proton NMR Spectrum
Nlele ọkọlọtọ	Standardkpụrụ ụlọ ọrụ
Ojiji	Nke etiti Afatinib, Afatinib Dimaleate

Ngwungwu & Nchekwa:

ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.

Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè na mmiri mmiri.

Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.

Ịdị ọcha Chromatographic:

Ngwa: Agilent 1200 HPLC HPLC chromatograph, DAD detector.
Ogidi: Agilent XDB-C18,250*4.6mm, 5μm
Usoro mkpanaaka: B: 1.95g sodium octane sulfonate + 8ml phosphoric acid + 5ml triethylamine + 500ml mmiri
C: acetonitrile
Nkwadebe nke usoro mkpanaka agwakọta: were 400ml B ngwọta na 100ml acetonitrile, gwakọta nke ọma na nke ọma, ma gbanye mmiri mmiri n'otu akụkụ.
Ọsọ ọsọ: 0.5ml/min54bar
Okpomọkụ kọlụm: 25 ℃
Ogologo ogologo: 210nm
Ngwọta ihe atụ: a na-eji usoro mkpanaka mee ihe dị ka ihe mgbaze, ihe atụ siri ike: 0.0040g / 2ml, nha nha 2.0μl.

Uru:

Ajụjụ:

Ngwa:

trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS: 848133-35-7) bụ reagent eji na nkwadebe nke tyrosine kinase na-egbochi antitumor agents.trans-4-Dimethylaminocrotonic Acid Hydrochloride nwere ike iji dị ka etiti nke Afatinib (CAS: 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Neratinib (CAS: 698387-09-6).Afatinib bụ ọgwụ akwadoro maka ọgwụgwọ carcinoma na-abụghị obere cell lung (NSCLC), nke Boehringer Ingelheim mepụtara.Ọ na-arụ ọrụ dị ka ihe mgbochi angiokinase.Dị ka Lapatinib na Neratinib, Afatinib bụ tyrosine kinase inhibitor (TKI) nke na-egbochikwa ihe na-eme ka mmadụ na-eto eto 2 (Her2) na epidermal growth factor receptor (EGFR) kinases.Afatinib abụghị naanị na-arụ ọrụ megide EGFRMmụba nke ọgbọ mbụ TKIs likeerlotinib ma ọ bụ gefitinib lekwasịrị anya, kamakwa megide ndị na-adịghị emetụta usoro ọgwụgwọ ọkọlọtọ ndị a.N'ihi ihe mgbakwunye ya megide Her2, a na-enyocha ya maka ọrịa kansa ara yana ọrịa EGFR na Her2 ndị ọzọ na-ebute.Neratinib nke ụlọ ọrụ US Wyeth mepụtara bụ ihe na-eme ka ọ bụrụ onye na-eme ihe na-emepụta ihe na-akpata epidermal (EGFR).Ọ bụ ọtụtụ ebe ebumnuche nke obere molecule tyrosine kinase inhibitors na HER 2 na HER1 mgbe Lapatinib gasịrị, ma bụrụkwa onye na-anabata ErbB tyrosine kinase inhibitor.Neratinib nwere ike họrọ igbochi HER-1 na HER-2 nke ezinụlọ EGFR (IC50 bụ 92 nmol / L na 59 nmol / L, n'otu n'otu).Nnyocha ụlọ ọgwụ gosiri na Neratinib gosipụtara mmetụta ọgwụgwọ dị ukwuu na ọrịa cancer akpa ume na-abụghị obere cell, cancer colon, na ọrịa ara ara.Nnwale nke usoro ahụike na-egosi na Neratinib gosipụtara ezigbo nrụpụta na ndidi nye ndị ọrịa HER-2 nwere ọrịa ara ara dị elu bụ ndị natara ọgwụgwọ Trastuzumab ma ọ bụ na ọ bụghị.Usoro Ⅲ usoro ọgwụgwọ ọrịa kansa ara agwụla na Septemba 2014.