Vitamin E-TPGS (Tocofersolan) CAS 9002-96-4 D-α-Tocopherol ≥25.0%
Shanghai Ruifu Chemical Co., Ltd bụ onye na-emepụta vitamin E-TPGS (Tocofersolan) (CAS: 9002-96-4) nwere oke mma.Ruifu Chemical nwere ike ịnye nnyefe zuru ụwa ọnụ, ọnụahịa asọmpi, ọrụ magburu onwe ya, obere na nnukwu ọnụọgụ dị.Ịzụta vitamin E-TPGS,Please contact: alvin@ruifuchem.com
| Aha Chemical | Vitamin E Polyethylene Glycol Succinate |
| Ụdị okwu | Vitamin E-TPGS;TPGS;Tocofersolan;α-Tocopherol Polyethylene Glycol Succinate;D-α-Tocopherol Polyethylene Glycol 1000 Succinate;Alfa-Tocopherol Polyethylene Glycol Succinate |
| Ọnọdụ Ahịa | N'ọkwa, Azụmahịa Azụmahịa |
| Nọmba CAS | 9002-96-4 |
| Usoro ihe omimi | C33H54O5.(C2H4O) n |
| Ebe Na-agbaze | 34.0 ~ 38.0 ℃ |
| Njupụta | 1.01g / cm3 |
| Mmetụta | Mmetụta Ikuku, Ọkụ Na-emetụ n'ahụ, Ọdịnihu nwere mmetụta |
| WGK Germany | 2 |
| Okpomọkụ nchekwa. | Ebe dị jụụ na nkụ (2 ~ 8 ℃) |
| COA & MSDS | Dị |
| Ihe atụ | Dị |
| Ezinụlọ ọgwụ | Ihe mejupụtara nke vitamin E |
| Ụdị | Ruifu Chemical |
| Ihe | Ụkpụrụ nyocha | Nsonaazụ |
| Ọdịdị | Gbanyụọ-Ọcha ka Ọcha odo odo Waxy siri ike | Na-akwado |
| njirimara (GC) | Oge njide nke isi ọnụ ọgụgụ kachasị elu nke ngwọta nlele dabara na nke ngwọta Standard | Na-akwado |
| Ebe Na-agbaze | 34.0 ~ 38.0 ℃ | 36.0 ~ 36.6 ℃ |
| Nyocha D-alpha Tocopherol | ≥25.0% (C29H50O2) | 26.4% |
| Tocopherol efu | ≤1.5% | Na-akwado |
| Ntụgharị akọwapụtara | ≥+24.0° | + 24.5 Celsius |
| Solubility na Mmiri | Enwere ike ịgbaze ihe nlele 20g na mmiri esi mmiri 80ml | Kpochapụ n'ime awa 3 |
| Uru acid | ≤0.27ml (0.10 N Sodium Hydroxide) | 0.22 ml |
| Ọla dị arọ (Pb) | ≤10ppm | <10ppm |
| Arsenic (dị ka) | ≤1pm | <1pm |
| Ndu | ≤3pm | <3pm |
| Mercury (Hg) | ≤0.1pm | <0.010pm |
| Ihe mgbaze fọdụrụnụ | ||
| Ethyl acetate | ≤50ppm | Achọpụtaghị |
| Ethanol | ≤50ppm | 23ppm |
| Ngụkọta ọnụ ọgụgụ efere | ≤1000CFU/g | <10CFU/g |
| Yist na ebu | ≤100CFU/g | <10CFU/g |
| Salmonella | Ihe ọjọọ | Ihe ọjọọ |
| Escherichia Coli | Ihe ọjọọ | Ihe ọjọọ |
| Psendomonas Aeruginosa | Ihe ọjọọ | Ihe ọjọọ |
| Staphylococcus Aureus | Ihe ọjọọ | Ihe ọjọọ |
| Spectrum infrared | Dabara na Ọdịdị | Na-akwado |
| Mmechi | A nwalela ngwaahịa a wee kwado nkọwa ndị enyere | |
ngwugwu:Kalama, Aluminom foil bag, 25kg / Cardboard Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Chekwaa n'ime akpa mechiri emechi.Chekwaa n'ebe dị jụụ, kpọrọ nkụ (2 ~ 8 ℃) yana ụlọ nkwakọba ihe ikuku na-ekupụ nke ọma pụọ na ihe ndị na-ekwekọghị ekwekọ.Chebe site na ìhè na mmiri mmiri.
Mbupu:Jiri ikuku na-ebuga ụwa niile site na FedEx / DHL Express.Nye nnyefe ngwa ngwa na ntụkwasị obi.
Nkọwa
Vitamin E Polyethylene Glycol Succinate bụ ngwakọta esterification nke d-alpha tocopheryl acid succinate na polyethylene glycol.Ngwakọta ester bụ isi nke polyethylene glycol mono-esterified na obere ego nke polyethylene glycol di-esterified.O nwere NLT 25.0% nke d-alpha tocopherol (C29H50O2).
Nchọpụta
• A. Gas Nyocha njirimara Chromatographic
Nyocha: Gaa n'ihu dị ka a gwara ya na nnwale maka Ọdịnaya nke Alpha Tocopherol.
Usoro nnabata: Oge njide nke isi kacha elu nke ngwọta Sample dabara na nke ọkọlọtọ ọkọlọtọ.
MGBE
• Ọdịnaya nke Alpha Tocopherol
Ihe mgbaze: 0.25 ml nke phenolphthalein TS na 1 l mmanya
Ngwọta ọkọlọtọ dị n'ime: 12 mg / ml nke ethyl arachidate na isooctane
Ihe ngwọta ọkọlọtọ: Nyefee 32.5 mg nke USP Alpha Tocopherol RS ka ọ bụrụ flask mmeghachi omume kwesịrị ekwesị.Tinye 2 ml nke pyridine na 0.5 ml nke N,O-bis(trimethylsilyl)trifluoroacetamide na 1% trimethylchlorosilane, ma kpoo flask na 100 maka 10 min.Kpoo ite ahụ, tinye 5.0 ml nke ihe ngwọta dị n'ime yana 20 ml nke isooctane sochiri, ma maa jijiji.
Ngwọta nlele: Nyefee nha nhata 0.100-0.160 g nke Vitamin E Polyethylene Glycol Succinate gbazere na 60 gaa na tube omenala (ihe dịka 20 cm ogologo na 2.5 cm n'obosara) nke nwere okpu ịghasa.Tinye 40-50 mg nke ascorbic acid na ibe ole na-esi esi, 20 ml nke ihe mgbaze sochiri ya.[Rịba ama-Megharịa ngwọta ahụ nke ọma n'enweghị mwepụta nke ọdịnaya.] Debe tube n'ime ihe mgbochi kpo oku setịpụrụ na 100-150.Mgbe ihe nlele ahụ gbazere n'ụzọ zuru ezu, tinye 0.25 g nke potassium hydroxide, ma gaa n'ihu na reflux maka 30 min.Wepu tube na okpomọkụ, na mgbe ọdịnaya ka na-ekpo ọkụ, tinye 1-2 ml nke hydrochloric acid dropwise ruo mgbe pink agba ga-apụ n'anya.[Ịdọ aka ná ntị—Mmeghachi omume pụrụ iche.Kwe ka acid ahụ gbadaa n'ime tube ka ọ ghara ịfesa.] Mee ka tube ahụ dị jụụ, wee saa akụkụ nke tube ahụ na mmiri 20 ml.Tinye 5.0 ml nke ngwọta dị n'ime, okpu, ma maa jijiji ka ị hụ na agwakọta nke ọma.Kwe ka tube guzoro ruo mgbe a ga-emepụta ọkwa abụọ dị iche iche.Nyefee 2.5-3.5 ml nke oyi akwa elu n'ime flask mmeghachi omume kwesịrị ekwesị, ma tinye 2.0 ml nke pyridine na-esote 2.5 ml nke N,O-bis (trimethylsilyl) trifluoroacetamide na 1% trimethylchlorosilane.Kpoo ite ahụ na 100 maka nkeji 10.Jụụ, wee tinye 12 ml nke isooctane.
Sistemụ chromatographic
(Lee Chromatography 621, Kwesịrị ekwesị Sistemu.)
Ụdị: GC
Ihe nchọpụta: ionization ọkụ
Ogidi: 0.25-mm × 15-m fused-silica capillary;kpuchie ya na ihe nkiri 0.25-µm nke oge G27
Okpomọkụ
Ntinye: 280
Onye nyocha: 345
Ogidi: Lee Tebụl 1.
Tebụl 1
Okpomọkụ izizi(°) Oke okpomoku (°/min) Okpomọkụ ikpeazụ (°) Jide oge na okpomoku ikpeazụ (min)
260 20 340 1
Ihe na-ebu gas: Helium
Ọnụego mmiri: 1.5 ml / min
Nha igba ogwu: 1µL
Ụdị ịgba ọgwụ: Oke nkewa, 200:1
Sistemu kwesịrị ekwesị
Ihe atụ: Ngwọta ọkọlọtọ
Kwesịrị ekwesị chọrọ
Ihe na-akpata ọdụ ọdụ: NMT 2.0 maka ọnụ ọgụgụ alfa tocopherol
Ọkọlọtọ emetụtara: NMT 2.0% maka oke mpaghara elu alfa tocopherol na mpaghara elu ọkọlọtọ dị n'ime.
Nyocha
Ihe atụ: Ngwọta ọkọlọtọ na Ngwọta Nlereanya
Gbakọọ pasent d-alpha tocopherol (C29H50O2) na akụkụ nke Vitamin E Polyethylene Glycol Succinate ewepụtara:
Nsonaazụ = (RU/RS) × (WS/WU) × 100
RU = ụkpụrụ nke ime (akụkụ kacha elu nke alpha tocopherol / mpaghara kacha elu nke ọkọlọtọ ime) site na ngwọta Sample.
RS = n'ime ọkọlọtọ ụkpụrụ (akụkụ kacha elu nke alpha tocopherol / mpaghara kacha elu nke ọkọlọtọ ime) site na ngwọta ọkọlọtọ.
WS = arọ nke USP Alpha Tocopherol RS eji kwadebe Standard ngwọta (mg)
WU = arọ nke Vitamin E Polyethylene Glycol Succinate ewepụtara iji kwadebe ihe ngwọta Sample (mg)
Usoro nnabata: NLT 25.0%
Nnwale akọwapụtara
• Ntụgharị anya, Ntugharị pụrụ iche 781S
[Rịba ama-Nnwale a na-achọpụta d-alpha tocopherol mgbe saponification gasịrị.]
Ihe ngwọta nlele: Nyefee 0.9 g nke Vitamin E Polyethylene Glycol Succinate, gbazere na 60, na tube ule kwesịrị ekwesị nke dabara na okpu, ma gbazee na 10.0 ml mmanya.Tinye tube n'ime ihe mgbochi kpo oku na 100-105.[Rịba ama-Reflux ngwọta ahụ nke ọma na-enweghị mwepụta nke ọdịnaya.] Mgbe ihe nlele ahụ gbazere n'ụzọ zuru ezu, gbakwunye 2-3 pellets nke sodium hydroxide, ma gaa n'ihu na-emegharị maka nkeji 30 ọzọ.Wepu tube na okpomọkụ, na mgbe ọdịnaya ka na-ekpo ọkụ, neutralize iji phenolphthalein dị ka egosi site na-eji nwayọọ nwayọọ na-agbakwunye 10 ml nke ngwakọta nke mmiri na hydrochloric acid (1:1) ruo mgbe pink agba na-apụ n'anya.[Akpachara anya-mmeghachi omume exothermic.Kwe ka ihe ngwọta acid ahụ gbadaa n'ime tube ahụ ka ọ ghara ịgbasa.] Mee ka tube ahụ dị jụụ, okpu, ma maa jijiji ruo mgbe ihe dị n'ime ya gwakọtara nke ọma.Tinye 25.0 ml nke heptane, okpu, ma maa jijiji maka 1 min iji hụ na agwakọta nke ọma.Kwe ka tube guzoro ruo mgbe a ga-emepụta ọkwa abụọ dị iche iche.Nyefee n'elu oyi akwa na tube omenala dị ọcha, wee tinye 10.0 ml mmiri na ngwọta enwetara.Kpuchie, maa jijiji, ma kwe ka akwa ahụ kewaa.Nyefee oyi akwa dị elu na tube dị ọcha, kpọrọ nkụ.Tinye 10.0 ml nke potassium ferricyanide ngwọta, kwadebere site na igbari 2 g nke potassium ferricyanide na 10.0 ml nke 0.2 M sodium hydroxide, ma dochie okpu.Ma jijiji nke ukwuu maka 45 s, ma kwe ka akwa ahụ kewaa maka 30 min.Ọ bụrụ na oyi akwa heptane dị n'elu doro anya, gaa n'ihu na nha maka ntụgharị pụrụ iche;Ọ bụrụ na edoghị anya, kpochaa n'elu sodium sulfate na-ekpo ọkụ tupu ịga n'ihu na ule ahụ.[Rịba ama-Jiri nsonaazụ ule ahụ maka Ọdịnaya nke Alpha Tocopherol iji gbakọọ ntụgharị a kapịrị ọnụ.]
Ụkpụrụ nnabata: NLT +24.0
• Solubility na mmiri
Ihe nlele: 20 g nke vitamin E gbazere Polyethylene Glycol Succinate
Nyocha: Tinye ihe nlele ahụ n'ime akpa iko na ihe ndọta.Tinye 80 ml nke mmiri esi ozugbo ka ị na-akpali.Kwe ka ọ dị jụụ n'ime ụlọ na-akpali akpali mgbe niile.
Usoro nnabata: Ihe ngwọta na-apụta ìhè n'ime awa 3.
• Uru acid
Ihe atụ: 1 g nke vitamin E Polyethylene Glycol Succinate
Nyocha: Gbasaa ihe nlele na 25 ml nke ngwakọta mmanya na ether (1: 1) nke etinyere na phenolphthalein na 0.1 N sodium hydroxide.Tinye 0.5 mL nke phenolphthalein TS, ma titrate na 0.10 N sodium hydroxide ruo mgbe ngwọta ahụ na-anọgide na-acha odo odo mgbe ọ masịrị 30 s.
Usoro nnabata: NMT 0.027 mEq/g, nke ya na NMT 0.27 mL nke 0.10 N sodium hydroxide
NKWUO GBASARA YA
• Nkwakọ ngwaahịa na Nchekwa: Chekwaa n'ime akpa siri ike, ma chekwaa na ọkụ.
• Ịde aha: Nkado ahụ na-egosi ọdịnaya d-alpha tocopherol, nke egosipụtara na mg/g.
• Ụkpụrụ ntụaka USP 11
USP Alpha Tocopherol RS
Kedu ka esi azụta?Biko kpọtụrụDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Ahụmịhe afọ 15?Anyị nwere ihe karịrị 15 afọ nke ahụmahụ na mmepụta na mbupụ nke a dịgasị iche iche nke elu mma pharmaceutical intermediates ma ọ bụ ezi kemịkal.
Isi ahịa?Na-ere ahịa ụlọ, North America, Europe, India, Korea, Japanese, Australia, wdg.
Uru?Ogo kachasị elu, ọnụ ahịa dị ọnụ ala, ọrụ ọkachamara na nkwado teknụzụ, nnyefe ngwa ngwa.
OgoNkwenye?Usoro njikwa mma siri ike.Ngwá ọrụ ọkachamara maka nyocha gụnyere NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, wdg.
Ihe atụ?Ọtụtụ ngwaahịa na-enye ihe nlele efu maka nyocha dị mma, ndị ahịa kwesịrị ịkwụ ụgwọ mbupu.
Nyocha ụlọ ọrụ?Nnabata nyocha ụlọ ọrụ.Biko mee oge oge tupu oge eruo.
MOQ?Enweghị MOQ.A na-anabata obere usoro.
Oge Mbuga ozi? Ọ bụrụ n'ime ngwaahịa, ekwenyere nnyefe ụbọchị atọ.
Ụgbọ njem?Site Express (FedEx, DHL), nke ikuku, site n'oké osimiri.
Akwụkwọ?Mgbe ọrụ ahịa gasịrị: COA, MOA, ROS, MSDS, wdg nwere ike ịnye.
Synthesis omenala?Nwere ike ịnye ọrụ nhazi ahaziri iche ka ọ dabara mkpa nyocha gị nke ọma.
Usoro ịkwụ ụgwọ?A ga-ebu ụzọ ziga akwụkwọ ọnụahịa Proforma mgbe nkwenye nke iwu, kpuchiri ozi ụlọ akụ anyị.Ịkwụ ụgwọ site na T/T (Telex Nyefee), PayPal, Western Union, wdg.
Vitamin E Polyethylene Glycol Succinate (Vitamin E-TPGS; TPGS; Tocofersolan) (CAS: 9002-96-4) bụ ngwaahịa sịntetik.Ọ dị ka ihe na-acha ọcha na-acha odo odo na-acha odo odo waxy siri ike ma na-enwechaghị ụtọ.Kemịkalụ, ọ bụ ngwakọta nke mejupụtara polyethylene glycol 1000 monoesterified, polyethylene glycol 1000 diesterified, polyethylene glycol 1000 efu, na tocopherol efu.
A na-eji Vitamin E Polyethylene Glycol Succinate mee ihe n'ọtụtụ ebe na nyocha ọgwụ, dị ka solubilizer, onye na-akwalite absorption, emulsifier, plasticizer na onye na-ebu mmiri na-adịghị edozi ma ọ bụ abụba soluble usoro nnyefe ọgwụ, dị ka mgbasa siri ike, onye na-ebu maka nnyefe ọgwụ anya, onye na-ebu maka intranasal. nnyefe ọgwụ, wdg Dị ka ihe mgbakwunye nri.
Vitamin E Polyethylene Glycol Succinate bụ ihe soluble mmiri nke vitamin E, a na-emepụta ya site na mmeghachi omume nke carboxyl otu vitamin E succinate na otu hydroxyl nke polyethylene glycol.N'ihi na ọ nwere ma vitamin E lipophilic otu na polyethylene glycol hydrophilic ogologo yinye, o nwere ezigbo surfactant Njirimara na mmiri solubility, nke nwere ike budata dịkwuo absorption nke insoluble ọgwụ na eriri afọ tract, ụba bioavailability.
N'ime afọ ndị na-adịbeghị anya, ọtụtụ nchọpụta achọpụtala na TPGS ọ bụghị nanị na enwere ike iji ya dị ka ihe ndị na-emepụta ọgwụ, ma nweekwa ọtụtụ njirimara pụrụ iche, dị ka ndị na-eme ka absorption na ndị na-agbanwe agbanwe na-eguzogide ọgwụ, TPGS nwekwara ike tinye ya na prodrugs, micelles, liposomes, TPGS-copolymer. ndị na-ebu iji melite solubility, permeability na nkwụsi ike nke nkwadebe, ka ha wee nweta ngwa ngwa, ntọhapụ na-achịkwa na mmetụta ezubere iche, na-akwalite absorption nke ọgwụ.
1. Pharmaceutical - Vitamin E-TPGS ukwuu enhances na absorption, bioavailability na irè nke ọgwụ Efrata (APIs)
2. Dietery supplements - Vitamin E-TPGS na-eji emepụta ihe mgbakwunye, karịsịa ndị e kere iji melite labsorption nke vitamin E na ndị ọzọ lipophilic nri na nutraceuticals.
3. Nri na ihe ọṅụṅụ - Vitamin E-TPGS nwere ike n'ọrụ iji wusie nri na ihe ọṅụṅụ, ihe ọṅụṅụ egwuregwu, mmiri na ihe ọṅụṅụ.
4. Nlekọta onwe onye - Vitamin E-TPGS na-eje ozi dị ka ethanol n'efu, hypoallergenic, emulsifier na-adịghị ewe iwe / onye na-ahụ maka nlekọta onwe onye na ngwa ịchọ mma.
5. Animal Nutrition Products - Vitamin E-TPGS na-enye a ukwuu absorbable na bioavailable vitamin E maka ụmụ anụmanụ na-adịghị arụ ọrụ nke ọma banye omenala iche iche nke vitamin E.
Vitamin E polyethylene glycol succinate bụ ihe esterified vitamin E (tocopherol) ewepụtara na-eji dị ka a solubilizer ma ọ bụ emulsifying gị n'ihi na ya surfactant Njirimara.N'ịbụ nke a na-emepụta, ọ bụ amphipathic na hydrophilic, n'adịghị ka tocopherols, ya mere ọ bụ ihe na-emepụta mmiri nke nwere ike iji mee ihe na usoro ọgwụ dị ka capsules, mbadamba nkume, extrusion na-ekpo ọkụ, microemulsions, ngwaahịa ndị dị n'elu, na parenterals.Otu n'ime ngwa kachasị mkpa bụ iji ya dị ka ụgbọ maka nhazi nnyefe ọgwụ dabere na lipid.A pụkwara iji ya mee ihe dị ka isi iyi nke vitamin E. Achọpụtala vitamin E polyethylene glycol succinate n'ihe gbasara usoro ọrụ ya ma mụọ dị ka onye na-egbochi Pglycoprotein.
Vitamin E polyethylene glycol succinate ekwekọghị na acid siri ike na alkalis siri ike.
GRAS edepụtara.Gụnyere na Ebe nchekwa data adịghị arụ ọrụ nke FDA (ophthalmic solution or drops; oral capsules, solution, tablet; topical solution or drops).Agụnyere na Ndekọ Canada nke Ngwa ndị na-abụghị ọgwụ anabatara.
