Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2 API Ogo dị elu
Nyefee Vonoprazan Fumarate na Intermediate emetụtara
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Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Aha Chemical | Vonoprazan Fumarate |
| Ụdị okwu | TAK-438 |
| Nọmba CAS | 1260141-27-2;881681-01-2 |
| Nọmba CAT | RF-API99 |
| Ọnọdụ Ahịa | Na Akụrụngwa, Mpụta Ihe ruru narị narị kilograms |
| Usoro ihe omimi | C21H20FN3O6S |
| Ibu molekụla | 461.463 |
| Ụdị | Ruifu Chemical |
| Ihe | Nkọwapụta |
| Ọdịdị | Ntụ ntụ kristal na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha |
| njirimara 1 H-NMR | Nkwekọ na Standard |
| njirimara IR | Ụdị absorption nke IR nke concordant sample nwere ọkọlọtọ ntụaka |
| njirimara HPLC | Oge njide nke concordant sample nwere ọkọlọtọ ntụaka |
| Ọdịnaya Mmiri | ≤0.50% |
| Ihe fọdụrụ na mgbanye | ≤0.20% |
| Ọla dị arọ (dị ka Pb) | ≤20ppm |
| Ihe ndị emetụtara | |
| adịghị ọcha A | ≤0.20% |
| adịghị ọcha B | ≤0.15% |
| adịghị ọcha C | ≤0.15% |
| Ọdịghị ọcha ọ bụla ọzọ | ≤0.10% |
| Mgbakọta adịghị ọcha | ≤1.0% |
| Ihe mgbaze fọdụrụnụ | |
| Methanol | ≤0.30% |
| Ethanol | ≤0.50% |
| Ethyl acetate | ≤0.50% |
| Usoro nyocha / nyocha | 98.0% ~ 102.0% (nke HPLC) |
| Nlele ọkọlọtọ | Standardkpụrụ ụlọ ọrụ |
| Ojiji | API |
ngwugwu: Kalama, Aluminom foil bag, kaadiboodu drum, 25kg / Drum, ma ọ bụ dị ka ndị ahịa chọrọ.
Ọnọdụ Nchekwa:Na-echekwa n'ime akpa ndị a kpuchiri ekpuchi na ebe dị jụụ na nke kpọrọ nkụ;Chebe site na ìhè, mmiri mmiri.
Vonoprazan Fumurate (TAK-438) (CAS: 1260141-27-2; 881681-01-2), proton pump inhibitor (PPI), bụ onye nwere ike na ọnụ na-arụ ọrụ potassium-competitive acid blocker (P-CAB), na antisecretory. ọrụ.Vonoprazan Fumarate na-egbochi ọrụ H +, K+-ATPase na porcine gastric microsomes nwere IC50 nke 19 nM na pH 6.5.Vonoprazan Fumarate (Takecab), chọpụtara ma mepụta Takeda na Otsuka, kwadoro PMDA nke Japan na December 2014. A na-ejikarị Vonoprazan Fumarate mee ihe maka ọgwụgwọ helicobacter pylori ọrịa, gastroesophageal reflux, peptic ọnyá afọ, duodenal ọnyá afọ, esophagitis, gastric. ọnyá afọ na ọrịa ndị ọzọ metụtara gastric acid.Ngwaahịa ahụ nwere mgbochi siri ike, na-adịgide adịgide nke secretion acid gastric.Na usoro ọgwụgwọ, Vonoprazan Fumarate nwere obere mmetụta na enzymes ndị ọzọ na obere mmetụta na ọrụ physiological nke ahụ.Ọ dị mma ma dịkwa mfe nnabata.
