N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS 152460-09-8 Imatinib Mesylate Intermediate High Purity
Commercial Supply Imatinib Mesylate and Related Intermediates:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Chemical Name | N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine |
| Synonyms | Imatinib Mesylate Intermediate; 2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine |
| CAS Number | 152460-09-8 |
| CAT Number | RF-PI228 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C16H13N5O2 |
| Molecular Weight | 307.31 |
| Melting Point | 188.0~193.0℃ |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | Yellow or Almost Yellow Powder |
| Purity | ≥98.0% (HPLC) |
| Moisture (K.F) | ≤0.50% |
| Total Impurities | ≤2.0% |
| Maximum Single Impurity | ≤1.0% |
| Residue on ignition | ≤0.50% |
| Heavy Metals | ≤20ppm |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Imatinib Mesylate (CAS: 220127-57-1) |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine (CAS: 152460-09-8) with high quality. It is an intermediate typically in the synthesis of Imatinib Mesylate (CAS: 220127-57-1).
Imatinib Mesylate is a small molecule that inhibits the c-Abl protein-tyrosine kinase, Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). A translocation event between chromosomes 9 and 22 generates the Philadelphia chromosome, which then produces the Bcr-Abl fusion protein with aberrant kinase activity that promotes rapid cell proliferation. Imatinib Mesylate binds up this crucial kinase, halting CML related growth. Imatinib Mesylate has further been displayed to inhibit PDGFR and tyrosine kinases associated with c-Kit. Formulations containing Imatinib Mesylate have been used in the treatment of various cancers.
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