Indapamide CAS 26807-65-8 Purity ≥99.5% (HPLC) API EP Standard Factory High Quality

Indapamide (CAS: 26807-65-8) is an antihypertensive and a diuretic. By inhibiting Na+ reabsorption at the proximal end of distal conflexion tubules, it produces diuretic effect and also blocks Ca2+ influx. It has a high selectivity to vascular smooth muscle, dilates peripheral small vessels and produces hypotensive effect.  But the effect on vascular smooth muscle stronger diuretic effect, below the diuretic doses can step-down, higher doses showed diuretic effect, but no thiazide diuretic shortcomings, namely not cause orthostatic hypotension, flush and reflective tachycardia, on blood picture, metabolism of blood fat,  sugar and renal function also had no obvious effect, therapeutic doses of heart rate, cardiac output, no significant changes in electrocardiogram (ecg) were It has no obvious effect on central nervous system and autonomic nerve.  Oral administration of 2 ~ 3 chemicalbook H produced a hypotensive effect, which was maintained for 24h.  Diuretic effect appeared at 3h and reached its maximum effect at 4 ~ 6h. Indapamide is suitable for mild and moderate primary hypertension, can also be used for congestive heart failure caused by water sodium retention, with renal failure are also applicable to the patients with high blood pressure, diabetes, hyperlipidemia, use antihypertensive effect is remarkable.