Irbesartan Intermediate Side Chain Hydrochloride CAS 151257-01-1 Purity >99.0% (HPLC) Factory

Short Description:

Chemical Name: 2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one Hydrochloride

Synonyms: Irbesartan Side Chain Hydrochloride

CAS: 151257-01-1

Purity: >99.0% (HPLC)

Appearance: White to Almost White Crystalline Powder

Intermediate of Irbesartan (CAS: 138402-11-6)

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Product Detail

Product Tags

Description:

Ruifu Chemical Supply Irbesartan Intermediates:
Irbesartan CAS 138402-11-6
Cyano-Irbesartan CAS 138401-24-8
Trityl Irbesartan CAS 138402-10-5
TTBB CAS 124750-51-2
Irbesartan Side Chain Hydrochloride CAS 151257-01-1

Chemical Properties:

Chemical Name	2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one Hydrochloride
Synonyms	Irbesartan Side Chain Hydrochloride; Irbesartan Lactam Impurity; Irbesartan Impurity A; 2-Butyl-4-spirocyclopentane-2-imidazolin-5-one Hydrochloride; 2-Butyl-1,3-diaza-spiro[4.4]non-1-en-4-one HCl
CAS Number	151257-01-1
CAT Number	RF-PI1894
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C11H18N2O·HCl
Molecular Weight	230.74
Solubility in Water	Soluble in Water
Melting Point	235.0~240.0℃
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	White to Almost White Crystalline Powder
Purity / Analysis Method	>99.0% (HPLC)
Loss on Drying	<0.50%
Residue on Ignition	<0.20%
Total Impurities	<1.00%
Proton NMR Spectrum	Conforms to Structure
Test Standard	Enterprise Standard
Usage	Intermediate of Irbesartan (CAS: 138402-11-6)

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

FAQ:

Application:

2-Butyl-1,3-diazaspiro[4.4]non-1-en-4-one Hydrochloride (CAS: 151257-01-1), also known as Irbesartan Side Chain Hydrochloride, is an Intermediate of Irbesartan (Avapro) (CAS: 138402-11-6). Irbesartan is an angiotensin II receptor inhibitor, angiotensin II receptors are divided into AT1, AT2, irbesartan can inhibit AngⅠtransform into AngII by selectively blocking the AT1 receptor of AngII, specifically antagonize angiotensin converting enzyme 1 receptor (AT1), the antagonism of AT1 is 8500 times than that of AT2, it can inhibit vasoconstriction and aldosterone release by selectively blocking the binding AngII with AT1 receptor and result in the antihypertensive effect. This product does not inhibit angiotensin converting enzyme (ACE), renin, and other hormone receptors, neither suppress the blood pressure regulation and the balance of sodium ion channels. Irbesartan can also reduce electrical remodeling of the myocardium, thereby reduce the mortality rate of patients with hypertension, it is the most effective drug for treatment of hypertension and cardiovascular disease.