Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API Factory High Purity
Manufacturer Supply Irinotecan and Related Intermediates:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Chemical Name | Irinotecan Hydrochloride Trihydrate |
| Synonyms | Irinotecan HCl Trihydrate; CPT-11 Trihydrate; Irinotecan HCL 3H2O |
| CAS Number | 136572-09-3 |
| CAT Number | RF-API52 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C33H38N4O6·HCl·3H2O |
| Molecular Weight | 677.20 |
| Melting Point | 250.0~256.0℃ (dec.) |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | Light Yellow or Yellow Crystalline Powder |
| Assay (w/w) | 98.0%~102.0% |
| Purity (HPLC) | ≥99.5% |
| Solubility | Slightly soluble in water, ethanol or chloroform, Practically Insoluble in acetone |
| Identification | by IR and HPLC, Conforms |
| Specific Optical Rotation | +60°~+73° |
| Water | 7.0%~9.0% |
| Residue of Solvents | Complies with ICH Requirements |
| Residue on Ignition | ≤0.20% |
| Chloride | 5.0%~6.0% |
| pH Value | 3.0~5.0 |
| Heavy Metals | ≤20ppm |
| Individual Impurities | ≤0.10% |
| Total Impurities | ≤0.50% |
| Storage Condition | Store at 2-8°C, In sealed containers and protect from light and moisture |
| Test Standard | Enterprise Standard |
| Usage | Active Pharmaceutical Ingredient (API) |
Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.
Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) with high quality.
Irinotecan Hydrochloride Trihydrate is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. lrinotecan hydrochloride, a semi-synthetic, water soluble derivative of the potent anticancer agent camptothecin, was launched in Japan for the treatment of lung, ovarian, and cervical cancers. lrinotecan exerts its antitumor activity via inhibition of topoisomerase I, a cellular enzyme that is involved in maintaining the topographic structure of DNA during the process of translation, transcription, and mitosis. lrinotecan undergoes de-esterification in vivo to yield an active metabolite, SN-38, which is 1000-fold more potent than the parent. Although being much less toxic than camptothecin, a significant number of patients in clinical trials exhibited side effects of leukopenia, diarrhea, nauseahromiting, and alopecia. Combination therapy of irinotecan with another widely used anticancer agent, cisplatin, has been reported to be superior to either agent alone. lrinotecan is in clinical trials for gastrointestinal, breast, skin, colorectal, pancreatic cancers, mesothelioma and non-Hodgkin's lymphoma.
