1-Metil-3-Pyrrolidinol CAS 13220-33-2 Kemurnian >98,0% (GC)
Ruifu Chemical minangka produsen utama 1-Methyl-3-Pyrrolidinol (3-Hydroxy-1-Methylpyrrolidine) (CAS: 13220-33-2) kanthi kualitas dhuwur.Ruifu Chemical bisa nyedhiyakake pangiriman ing saindenging jagad, rega sing kompetitif, layanan sing apik, jumlah cilik lan akeh sing kasedhiya.Tuku 1-Methyl-3-Pyrrolidinol,Please contact: alvin@ruifuchem.com
Jeneng Kimia | 1-Metil-3-Pyrrolidinol |
sinonim | N-Metil-3-Pyrrolidinol;3-Hydroxy-1-Methylpyrrolidine;N-Metil-Pyrrolidin-3-ol;N-Metil-Pyrrolidinyl Alkohol;1-Methylpyrrolidin-3-ol |
Status Simpenan | Ing Saham, Produksi Komersial |
Nomer CAS | 13220-33-2 |
Formula Molekul | C5H11NO |
Bobot Molekul | 101,15 g / mol |
Titik didih | 75 ℃ / 12 mmHg |
Titik Flash | 71 ℃ |
Kapadhetan | 0,921 g/mL ing 25 ℃ (lit.) |
Indeks bias n20/D | 1.464 (liter.) |
Sensitif | Sensitif Udara, Higroskopis |
Kelarutan | Larut ing banyu, larut ing alkohol, eter lan Benzene |
COA & MSDS | kasedhiya |
Sampel | kasedhiya |
asale | Shanghai, China |
Merk | Kimia Ruifu |
barang | Standar Inspeksi | Asil |
Penampilan | Cairan Kuning Muda | Cairan Kuning Muda |
Banyu dening Karl Fischer | <0,20% | 0,15% |
Kemurnian / Metode Analisis | > 98,0% (GC) | 98,57% |
Kapadhetan (20 ℃) | 0.920~0.923 | tundhuk |
Indeks bias n20/D | 1.463~1.465 | tundhuk |
Spektrum Infrared | Konsisten karo Struktur | tundhuk |
Spektrum 1H NMR | Konsisten karo Struktur | tundhuk |
Kesimpulan | Produk wis diuji & tundhuk karo spesifikasi sing diwenehake |
Paket:Botol, tas Aluminium foil, 25kg / Drum Karton, utawa miturut kabutuhan pelanggan.
Kondisi panyimpenan:Tansah wadhah ditutup kanthi rapet lan simpen ing gudang sing adhem, garing (2 ~ 8 ℃) lan kanthi ventilasi sing adoh saka bahan sing ora cocog.Nglindhungi saka cahya lan Kelembapan.
Pengiriman:Ngirim menyang donya liwat udhara, dening FedEx / DHL Express.Nyedhiyakake pangiriman sing cepet lan dipercaya.
Tambah 1,2,4-Butanetriol lan asam asetat glasial menyang pot reaksi, nglakoake lan panas kanggo bab 100 ℃, nambah gas hidrogen klorida garing, lan nanggepi ing 90 ~ 110 ℃ kanggo 30h, nalika jumlah gedhe saka hidrogen klorida wiwit kanggo katon ing gas buntut, titik pungkasan reaksi dicenthang lan hidrogen klorida mandheg.Sawise adhem, materi kasebut dibuwang, dikumbah nganggo larutan natrium karbonat jenuh, lan distilasi kanthi tekanan sing sithik, lan 120 nganti 135 ℃.(12,6 kanggo 13. 3kPa) pecahan, I.e., 1,4-Dichloro-2-Butanol materi lenga, ngasilaken 50% ~ 60%.
Cyclization solusi banyu saka 1,4-Dichloro-2-Butanol lan Methylamine ditambahake menyang pot cyclization, lan digawe panas kanggo 120 ℃.Ing tutup dadi panas, lan reaksi iki diudhek kanggo 10h.Sawise adhem, natrium hidroksida padhet ditambahake, lan uyah anorganik sing endapan disaring.Lapisan lenga dipisahake lan kena distilasi vakum, lan fraksi 76-85 ℃.(2,1 kPa) diklumpukake dadi produk rampung.Ekstraksi lapisan banyu karo benzena uga ngasilake bagean saka 1-Methyl-3-Pyrrolidinol.Ngasilake kira-kira 60%.
3. Proses utama:
3.1 Proses reaksi sing diganti: ngontrol wektu reaksi lan ndeteksi titik pungkasan reaksi
3.2 Proses distilasi vakum saka 1,4-Dichloro-2-Butanol: kontrol derajat vakum saka distilasi vakum lan suhu fraksi
3.3 Proses reaksi siklisasi: kontrol suhu lan wektu reaksi
3.4 1-Methyl-3-Pyrrolidinol proses distilasi vakum: kontrol derajat vakum distilasi vakum lan suhu fraksi
4. Titik kontrol kualitas:
Titik kontrol kualitas 1: 1,2,4-Butanetriol standar kualitas bahan baku
Titik kontrol kualitas 2: Standar kualitas kontrol pusat kanggo reaksi siklisasi
Titik kontrol kualitas 3: 1,4-Dichloro-2-Butanol standar kualitas intermediate
Titik kontrol kualitas 4: 1-Methyl-3-Pyrrolidinol standar kualitas produk rampung
Isi Kelembapan: Njupuk prodhuk iki lan tes miturut metode penentuan kelembapan (Cara pisanan A Lampiran Ⅷ M, 2010 Edition saka Republik Rakyat China Pharmacopoeia).Isi kelembapan ora luwih saka 0,2%.
Kapadhetan Relatif: Kapadhetan relatif prodhuk iki (Lampiran VI A saka Part II, edisi 2010) yaiku 0.920~0.923
Indeks bias: Indeks bias prodhuk iki (Lampiran VI F saka Part II edisi 2010) yaiku 1.463~1.465
Penentuan Isi: Isi 1-Methyl-3-Pyrrolidinol ngirim ora kurang saka 98,0% dening kromatografi gas (Lampiran Ⅴ E, Part II, 2010 edition).
Kolom: Kapiler ing silika cair SPB-5, diameter internal 0,32mm, dawane 30m
T Injector: 300 ℃
FID: 320 ℃
T Column: 80 ℃ kanggo 5 menit, kanggo 200 ℃ ing 5 ℃ / min, banjur ing 200 ℃ kanggo 7 min
Carrier: Helium ing 1 ml / min
Rasio pamisah: 100: 1
Injeksi: 1 mikroliter
Solusi tes: dissolve 200mg saka sampel ing analisis ing 10ml metanol.Nyuntikake 1 mikroliter.1μl disuntikake menyang kromatografi gas kanggo ngrekam kromatogram.Isi 1-Methyl-3-Pyrrolidinol diitung kanthi metode normalisasi area puncak.
Carane Tuku?Mangga kontakDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Pengalaman 15 Taun?Kita duwe luwih saka 15 taun pengalaman ing Pabrik lan ekspor saka sawetara saka sudhut intermediet pharmaceutical kualitas dhuwur utawa bahan kimia nggoleki.
Pasar Utama?Adol menyang pasar domestik, Amerika Utara, Eropa, India, Korea, Jepang, Australia, lsp.
Kaluwihan?Kualitas unggul, rega terjangkau, layanan profesional lan dhukungan teknis, pangiriman cepet.
KualitasJaminan?Sistem kontrol kualitas sing ketat.Peralatan profesional kanggo analisis kalebu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Sampel?Umume produk nyedhiyakake conto gratis kanggo evaluasi kualitas, biaya pengiriman kudu dibayar dening pelanggan.
Audit Pabrik?Audit pabrik welcome.Mangga nggawe janjian ing advance.
MOQ?Ora MOQ.pesenan cilik ditrima.
Wektu Pangiriman? Yen ing saham, telung dina pangiriman dijamin.
Transportasi?Miturut Express (FedEx, DHL), dening Air, dening Sea.
Dokumen?Sawise layanan sales: COA, MOA, ROS, MSDS, etc.
Sintesis khusus?Bisa nyedhiyakake layanan sintesis khusus sing cocog karo kabutuhan riset sampeyan.
Syarat-syarat pembayaran?Invoice Proforma bakal dikirim dhisik sawise konfirmasi pesenan, dilampirake informasi bank kita.Pembayaran kanthi T / T (Transfer Telex), PayPal, Western Union, lsp.
Simbol Bahaya Xi - Irritant
Kode Resiko
36/37/38 - Iritasi ing mripat, sistem pernapasan lan kulit.
Katrangan safety
S26 - Yen kena mripat, langsung mbilas nganggo banyu akeh lan njaluk saran medis.
S36/37/39 - Nganggo sandhangan protèktif, sarung tangan lan protèktif mripat/pasuryan sing cocog.
WGK Jerman 3
Kode HS 2933990099
1-Methyl-3-Pyrrolidinol (3-Hydroxy-1-Methylpyrrolidine) (CAS: 13220-33-2) digunakake minangka perantara sintesis organik, digunakake minangka perantara farmasi ing industri farmasi.
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