2,3-Dihydrobenzofuran CAS 496-16-2 Ramelteon Intermediate Purity >99,0% (GC)
Produsen lan Supplier Utama, Perantara Ramelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-siji CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
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Jeneng Kimia | 2,3-Dihydrobenzofuran |
sinonim | Coumaran;2,3-Dihydro-2,3-Benzofuran;2,3-Dihydrobenzo[b]furan;2,3-Dihydro-1-Benzofuran |
Nomer CAS | 496-16-2 |
Nomer CAT | RF2884 |
Status Simpenan | Ing Simpenan, Kapasitas Produksi 20 Ton saben Wulan |
Formula Molekul | C8H8O |
Bobot Molekul | 120.15 |
Titik Lebur | -21 ℃ |
Titik didih | 188,0 ~ 189,0 ℃ (lit.) |
Titik Flash | 66 ℃ |
Kelarutan | Alkohol: larut |
Cathetan Bahaya | iritasi |
TSCA | ya wis |
Kode HS | 29329995 |
Suhu panyimpenan | Disegel ing Kering, Suhu Kamar |
Merk | Kimia Ruifu |
Item | Spesifikasi |
Penampilan | Cairan bening ora ana warna utawa kuning |
Kemurnian / Metode Analisis | > 99,0% (GC) |
Banyu (dening Karl Fischer) | <0,50% |
Kapadhetan (20 ℃) | 1.065~1.085 |
Indeks bias n20/D | 1.547~1.551 |
Impurity Tunggal | <0,50% |
Total Impurities | <1.00% |
Proton NMR Spectrum | Conforms kanggo Struktur |
Test Standar | Standar Perusahaan |
Panggunaan | Pharmaceutical Intermediate of Ramelteon (CAS: 196597-26-9) |
Paket: Botol Fluorinated, 25kg / Drum, utawa miturut kabutuhan pelanggan
Kondisi panyimpenan:Simpen ing wadhah sing disegel ing papan sing adhem lan garing;Nglindhungi saka cahya lan Kelembapan
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2,3-Dihydrobenzofuran (CAS: 496-16-2) digunakake akeh ing sintesis senyawa trisiklik lan uga minangka bahan baku penengah kanggo sintesis sawetara obat penting.2,3-Dihydrobenzofuran bisa digunakake minangka penengah saka Ramelteon (CAS: 196597-26-9).Ramelteon, dipasarake minangka Rozerem dening Takeda Pharmaceuticals Amerika Utara, minangka agen turu sing selektif ngiket reseptor MT1 lan MT2 ing nukleus suprachiasmatic (SCN), tinimbang ngiket karo reseptor GABAA, kayata karo obat kaya zolpidem.Nanging ora katon kanggo nyepetake wiwitan turu utawa jumlah turu sing ditindakake dening wong.Iki disetujoni dening US Food and Drug Administration (FDA) kanggo panggunaan jangka panjang.Ramelteon ora nuduhake ikatan sing cukup kanggo reseptor GABAA, sing ana gandhengane karo efek anxiolytic, myorelaxant, lan amnesic.Ora kaya umume perawatan insomnia sing ngarahake kompleks reseptor GABA (asam g-aminobutyric), ramelteon minangka agonis reseptor melatonin.Utamane, nduweni selektivitas dhuwur kanggo subtipe MT1 lan MT2, sing wis ditrapake ing pangopènan irama sirkadian, liwat reseptor MT3 sing tanggung jawab kanggo fungsi melatonin liyane.2,3-Dihydrobenzofuran uga digunakake ing sintesis agen antitumor benzofuran sulfonylureas, HIV protease inhibitor asam amino hydroxyethylenesulfonyl, matriks metalloproteinase inhibitor aril sulfinyl isoxime hydroxamic acid, etc.