4-Benzyl-2-Hydroxymorpholin-3-one CAS 287930-73-8 Kemurnian >99,0% (HPLC) Aprepitant Intermediate Factory
Produsèn lan supplier anjog
Perantara saka Aprepitant (CAS: 170729-80-3)
4-Benzyl-2-Hydroxymorpholin-3-siji CAS 287930-73-8
(R)-1-[3,5-Bis(trifluoromethyl)fenil]etanol CAS 127852-28-2
Please contact: alvin@ruifuchem.com
| Jeneng Kimia | 4-Benzyl-2-Hydroxymorpholin-3-siji |
| sinonim | 4-Benzyl-2-Hydroxy-Morpholin-3-siji;2-Hydroxy-4-(Phenylmethyl)-3-Morfolinon;Aprepitant Impurity 48;Fosaprepitant Impurity 23;Aprepitant Intermediate Ⅱ |
| Nomer CAS | 287930-73-8 |
| Nomer CAT | RF2660 |
| Status Simpenan | Ing Simpenan, Skala Produksi Nganti Ton |
| Formula Molekul | C11H13NO3 |
| Bobot Molekul | 207.23 |
| Titik Lebur | 134,0 kanggo 138,0 ℃ |
| Titik didih | 441,7 ± 45,0 ℃ |
| Kapadhetan | 1,292±0,06 g/cm3 |
| Kelarutan ing banyu | DMSO (Rada), Metanol (Rada, Dipanasake) |
| Merk | Kimia Ruifu |
| Item | Spesifikasi |
| Penampilan | Bubuk Kristal Putih nganti Putih |
| Kemurnian / Metode Analisis | > 99,0% (HPLC) |
| Titik Lebur | 134,0 kanggo 138,0 ℃ |
| Banyu (dening Karl Fischer) | <0,50% |
| Sisa ing Ignition | <0,20% |
| Total Impurities | <1.00% |
| Proton NMR Spectrum | Conforms kanggo Struktur |
| Test Standar | Standar Perusahaan |
| Panggunaan | Intermediate of Aprepitant (CAS: 170729-80-3) Obat Antiemetik |
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4-Benzyl-2-Hydroxymorpholin-3-one (CAS: 287930-73-8), minangka perantara saka Aprepitant (CAS: 170729-80-3), digunakake minangka obat antiemetik.Aprepitant minangka antagonis reseptor neurokinin-1 (NK-1) lan kalebu agen ngobati muntah nalika kemoterapi kanker.Iki pisanan kasil dikembangake dening Merck Company (Jerman).Ing Maret 2003, US Food and Drug Administration nyetujoni kanggo digunakake ing perawatan saka kemoterapi muntah.Prodhuk iki nduweni karemenan selektif dhuwur kanggo manungsa nalika duwe karemenan kurang kanggo serotonin, dopamin lan karemenan reseptor glucocorticoid.Aprepitant, nalika digabungake karo inhibitor reseptor 5-HT3 (kayata ondansetron hydrochloride) lan dexamethasone kortikosteroid, bisa luwih nyuda emesis akut lan (utawa) sing ditundha cisplatin.Nglamar obat iki mung bisa duwe sawetara efek pencegahan.
![(R)-1-[3,5-Bis(trifluoromethyl)fenil]etanol CAS 127852-28-2 Kemurnian >99,0% (GC) Aprepitant Intermediate](https://www.ruifuchemical.com/uploads/R-1-35-Bistrifluoromethylphenylethanol-CAS-127852-28-2-300x300.jpg)